Canadian study has found an aberrant interferon roll reversal

[Guest guest]

Study published in the journal Blood, has found that type 1 interferon/STAT3

normally a tumour suppressor reverses to a cell growth stimulator in aggressive

CLL cells like 11q and 17p.

CLL cells with aggressive clinical features were found to also express high

levels of reactive oxygen species (ROS) which decrease tyrosine phosphatase

activity.

It is much more complicated than this, but this is the gist of it.

The researchers suggest that: " Anti-oxidants or STAT3-kinase inhibitors might

improve the outcome of IFN-therapy in CLL by restoring normal signalling. "

~chris

CLL CANADA