CLL much different than we thought...

[Guest guest]

This is perspective article " Inflammation, the microenvironment and chronic

lymphocytic leukemia " by Federico Caligaris-Cappio

Department of Oncology and Division of Molecular Oncology, San Raffaele

Scientific Institute and Università Vita-Salute San Raffaele, Milano, Italy.

It explains how we are beginning to understand what CLL is and how it

works...based on the idea of cell proliferation in the nodes and spleen.

" CLL cells circulating in the peripheral blood are the tip of the iceberg. The

most significant pathophysiological events occur in tissues where leukemic cells

are activated by exposure to antigens, although it is still unclear where and

how this exposure takes place. "

Full PDF

http://www.haematologica.org/cgi/reprint/96/3/353.pdf

~chris

CLL CANADA

http://cllcanada.ca