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Imagining a cure

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This article describes new treatment modalities for melanoma

utilizing the targeting of T cells. While the results of

this work sound impressive, lets keep in mind that " CLLers "

are still light-years ahead in terms of treatment success

and fortunately do not have to contend with what melanoma

patients have to.

As an aside, we do have a clinical trial that will open

shortly using two currently approved agents, denileukin

diftitox (Ontak) and rituximab, to attempt to induce an

immune response against the CLL cells by depleting the

regulatory T cells, which are thought to play a role in

preventing the immune system from attacking the cancer

cells. While this approach is very intriguing, it will

still be very nice to have PCI-32765 and CAL-101 to offer

patients.

Rick Furman, MD

> Maybe this therapy is useful for b cell lymphomas too..

> I don't understand if suitable for CLL however...

>

> http://f1000scientist.com/article/display/58067/

>

> carla

>

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