Re: Re: Transformation to MDS

[Guest guest]

This probably is MDS secondary to treatment, although CLL can occur with

MDS as two spontaneous diseases - I wrote up several cases in the 1980s.

Treatment of MDS is often supportive care with transfusions and antibiotics as

required. Revlimid and azacytidine are sometimes used for specific types of

MDS and so is low dose ara-C. However stem cell transplant is the only

curative approach.

Terry Hamblin MD

In a message dated 16/02/2011 17:36:16 GMT Standard Time,

karls@... writes:

Dear Jillayn,

Did s/he say that the MDS has transformed to AML? ...

My understanding is that MDS is not likely a

transformation from CLL - but a treatment-related risk

affecting stem cells; and that there are many kinds of MDS

and some types can be observed and managed.

In cases where a transformation to AML occurs (from MDS) I

think a transplant is often recommended in transplant

eligible persons? ... just a layperson's impression.

See also Trisomy 8 in B-cell chronic lymphocytic leukemia

_http://bit.ly/e69Apa_ (http://bit.ly/e69Apa)

All the best,

Karl

>

> I am 59 year old female; dx in 2000 with 6q deletion; tx 6 cycles FCR

2004, CR for 3 1/2 yrs, FISH done in 12/2007 revealed 11q and 13q deletions;

pursued SCT summer/2009, found MUD/decided to wait; developed ITP 2010, tx

IVIG monthly 8/2010 - 2/2011, HDMP 8/1-12/30/10, Rituxan 1/24 & 2/1/11;

fever, dropping counts past 2 weeks

> I had BMB and CT scan 2/11/11 and my oncologist told me today that my

CLL has transformed into MDS (Trisomy 8 in 58% of cells). My lymphs are 6.0,

neutrophils 1.16, rbc 3.1, hgb 10.5. He says not to treat right now but to

investigate transplant.

> I would appreciate any advice and tx options.

> Jillayn Wolleat

>

[Guest guest]

I have just posted my take on the place of alkylating agents in patients

with del 11q on my blog at _http://mutated-unmuated.blogspot.com/_

(http://mutated-unmuated.blogspot.com/)

Terry Hamblin MD