11q - role of elevated INSR

[Guest guest]

A study at the University of Michigan published in Clinical Cancer Research Feb

9th, 2011 has a finding of a high-level insulin receptor (INSR) expression in

the majority of CLL with del11q.

quote:

" High INSR mRNA expression in 11q CLL (~10-fold higher mean levels than other

genomic categories) was confirmed by Q-PCR in 247 CLL cases. "

" Higher INSR levels correlated with shorter time to first therapy (TTFT) and

shorter overall survival (OS). In bivariate analysis, INSR expression predicted

for rapid initial disease progression and shorter OS in ZAP-70 low/negative CLL.

Finally, in multivariate analysis (ZAP-70 status, IgVH status and INSR

expression), we detected elevated hazard ratios and trends for short OS for CLL

cases with high INSR expression (analyzed inclusive or exclusive of cases with

del11q). "

" Our aggregate biochemical and clinical outcome data suggest biologically

meaningful elevated INSR expression in a substantial subset of all CLL cases,

including many cases with del11q. "

end quote:

Full Paper

http://clincancerres.aacrjournals.org/content/early/2011/02/09/1078-0432.CCR-10-\

2058.long

Clearly the 11q story is not over...

~chris