PI3K Alpha isoform suggested target

[Guest guest]

CAL101 is a PI3-K delta inhibitor.

A paper to be presented at the EHA Congress looks at PI3-K-

isoform 'alpha'.

CLL cells express all four PI3-K-p110 isoforms (alpha, beta,

gamma and delta) at the mRNA and protein at higher levels

than samples of healthy individuals.

Targeting the PI3K pathway with alpha isoform-specific

inhibitors significantly induces apoptosis in CLL cells and

overcome the supportive effect of bone marrow stromal cells.

Source:

http://www.eventure-online.com/eventure/publicAbstractView.do?id=163060 & congress\

Id=4634

or

http://tinyurl.com/4xu3nhy