Re: Mutated/Unmutated (was: Off CAL-101 trial, and Bone marrow response)

[Guest guest]

I've done a lot of reading since diagnosis and my

understanding has been that mutation status is a separate

marker from chromosomal deletions, not a qualifier. But I do

know each of their chromosomal deletions as well.

:

13q14 deletion, Unmutated igVH

n:

11q deletion, Mutated igVH

11q is not as worrisome when the patient is Mutated. In

combination with an Unmutated status, it usually means more

aggressive disease.

13q14 is usually the more benign CLL, except in the low

percentage of patients who have this deletion with the

Unmutated igVH gene. No matter what your other markers,

being Unmutated usually means you will have more issues and

treatment will be more challenging. But there are exceptions

on both sides of the fence. Some Mutated patients will not

do as well as expected and some Unmutated patients will do

better than expected.

[Guest guest]

Do remember to check out the CIG website which has a great

deal of this information.

http://www.cllinfogroup.org/

>

> > is unmutated and his mom (n) is mutated. They have

> > different markers.

>

> Sometimes I see unqualified (i.e., not otherwise described)

> references to " Mutated " or " Unmutated " . Which specific

> mutation (11q? 13q? 17p? or?) is intended when " Mutated "

> or " Unmutated " is mentioned without any qualifier?