Re: My CLL not even in the Blood Yet

[Guest guest]

At this level it should be called MBL, not CLL. It is

present in about 4% of the population and may never develop

into CLL.

In a message dated 03/05/2011 21:27:08 GMT Daylight Time,

lecody2001@... writes:

That's right, I was " accidentally " dx'd with CLL last week.

It is still only in the bone marrow and it has only

compromised 2% of the marrow cells.

[Guest guest]

What is MBL and it's nice to know that it just may not amount

to anything but why would the Oncologist not mention this?

She seemed confident that it was CLL.

Dr. Hamblin wrote:

> At this level it should be called MBL

[Guest guest]

MBL - monoclonal B cell lymphocytosis - has the same markers

as CLL but the B lymphocyte count is less than 5000 per cu

mm and there are no significant lymph node masses. It is

very common - 4% of the population over 40 - and does not

usually progress to CLL.

In a message dated 03/05/2011 23:37:36 GMT Daylight Time,

lecody2001@... writes:

What is MBL and it's nice to know that it just may not amount

to anything but why would the Oncologist not mention this?

She seemed confident that it was CLL.

[Guest guest]

I looked at the paper that was suggested about MBL/CLL and

did not really understand most of it. So I shall reproduce

the Flow Cytometry Report in part, all spelling errors on

me.

Diagnosis Comment:

There is a small population of B Cells representing 2% of

all cells (21% of gated lymphoid cells) displaying co-

expression of CD5 and CD20. This population appears to show

negative/dim staining for surface immunoglobulin light

chains. The features are worrisome for mininal involvement

by a lyphoproliferative process, particularly CLL/SLL.

Correlation with the morphology is strongly recommended.

Gross and Microscopic Information:

source Bone marrow flow Cytometry

Microscopic

Gated population: Flow cytometric immunophentoyping is

performed using antibodies to the antigens listed in the

table below. Electronic gates are placed around a cell

cluster displaying light scatter properties corresponding to

lymphocytes and blasts.

- Abnormal Cells in lymphocyte population 21%

- Phenotype of Abnormal Cells :CD5, CD19 CD20,CD21, CD22,

CD23, HLA- Dr

And on final comment:

The size, location, and cytology of the lymphocytes in the

lymphoid aggregate is consistent with marrow involvement

with a lymphoproliferative disorder and particularly early

CLL/SLL. No metastatic tumor was identified.

Flow cytometry performed on this case showed a small

population of B cells.

I will still forward the paper on MBL v CLL/SLL to the

Oncologist.

Also, what do you mean my lymph node masses? Increased size

of lymph nodes or something else? Because I have quite a few

enlarged nodes which may or may not have something to do

with this possible CLL or more likely they are associated

with the lung since they are in the chest and have been this

way for the last 12 years that we know of.

Thank you

C