Re: VEGF secretion by CLL cells

[Guest guest]

Dr Furman

Thank you for your reply. I would be grateful if you would

be able to answer my novice musings. Even if it is to

dispel them.

Some of my questioning was prompted by my development of

many micro capillaries at the skin surface around my neck

shoulders and chest, rash like in appearance. I am almost

dismissed without answers, could VEGF be contributing to

this. This is Part of my reasoning in the value of

considering EGCG as a way of inhibiting VEGF. I understand

in vitro experiments may have produced different results to

those experienced by the few who have trialled agents too

inhibit VEGF. That some responses have been achieved by a

few trialled during early CLL. From what I remember this

was a small trial is there any other work in progress in

this area?

A curious thought that keeps tugging at me is wondering how

much of a role VEGF plays in developing micro environments

that allow CLL cells to congregate in tissue and shape that

environment. I have often wondered about conditions such as

RA which too cause expression of VEGF and increase

endothelial permeability and swelling and also stimulate

angiogenesis.

Thinking about these inflammatory micro environments has me

wondering if accompanying RA could assist CLL progression

in CLL types that express little VEGF. In reverse, if CLL

cell Secretion of VEGF could be a factor contributing to us

experiencing arthritic inflammatory type conditions?

I guess I wonder, how much influence could VEGF over

expression, contribute to many of our bizarre symptoms,

directly or indirectly.

Kind regards

Nick{UK}

Trisomy 12, CD38+,unmutated

[Guest guest]

Thank you for your email replies, this brings me up to speed

on EGCG and the cancelled Mayo Polyphenon-E study. How can

we find a “clean” source without gallons of luke warm tea?

This article was just published in Medical News Today,

following new research from Belgium, published in Nature

this week. http://www.medicalnewstoday.com/articles/236398.php

Tests were carried out on mice, they were given an antibody

that reduced new blood vessel growth. They found this

reduced the cancer stem cell pool and shrank the tumors,

suggesting that skin cancer stem cells rely on the presence

of blood vessel cells. In CLL we know that VEGF has a role

in stimulating PKCâ expression and VEGF is implicated as a

factor contributing to the anti apoptosis survival loop in

CLL cells. Could similar mechanisms also have been

interrupted in this study?

”This could be viewed as an indirect effect of VEGF on the

stem cancer cells, and indeed there are already some anti-

cancer drugs that target this effect by blocking VEGF and

its receptors. But what if VEGF also has a direct effect on

stem cancer cells? Might this account for the efficiency

with which the VEGF blockers work, as has been suggested in

other studies, asked the authors?”

Can anyone point me towards CLL studies testing VEGF

inhibiters or Blockers?

Kind regards

Nick(UK)

[Guest guest]

It is important to remember that none of these cytokines

work in isolation. We do see very high VEGF levels in CLL

and VEGF probably plays a very important role in CLL cell

survival and the associated disease progression. I do not

believe blood vessels themselves play a role as much as they

are generated by the high levels of VEGF. The VEGF likely

works in enhancing CLL cell survival separately from blood

vessel growth, but we do see a great deal of blood vessel

growth as a side effect.

Rick Furman, MD

Nick wrote:

/message/16225

[Guest guest]

Nick,

I suggest that you join

cllstudygroup/

a group focused on this type of basic research.

Ron

Nick wrote:

Can anyone point me towards CLL studies testing

VEGF inhibiters or Blockers?