Re: Unsuccessful SCT Exclusion for Cal-101?

[Guest guest]

I didn't get a response to my query. I'm wondering whether

my husband might be eligible to participate in Cal-101

trials. His CLL is now extremely aggressive.

Brief history is below. He also has borderline kidney

function.

Thanks,

Anne Brown

________________________________

From: Anne Brown <missbrown2u87@...>

Sent: Thu, May 5, 2011 8:45:27 AM

My husband underwent a mini-allo SCT at HUMC in 2009. He

rejected the graft and stopped taking all immune suppressive

drugs at the time. He was in remission until about a month

ago.

He was dx in 1998 and has had a lot of different treatments

(leukeran, 2 cycles of fludarabine, bendamustine and rituxan

plus more fludarabine, tbi and rabbit atg prior to

transplant). His immune system has suffered. He also has

well compensated cardiomyopathy.

My question is if this excludes him from the Cal-101 trials.

FISH testing shows 11q deletion. We have an appointment

next week to discuss what to do next. His doc mentioned

possibly starting revlimid.

Thank you.

Anne Brown

[Guest guest]

Not necessarily. There are many CAL-101 trials going on and

prior allogeneic transplant does not exclude him.

>

> I didn't get a response to my query. I'm wondering whether

> my husband might be eligible to participate in Cal-101

> trials. His CLL is now extremely aggressive.

[Guest guest]

Anne,

I know of one patient in the Stanford PCI-32765 trial who

had a failed SCT. I would imagine there are more as well,

for the relapsed /refractory arms of the studies.

Hope all goes well for your husband.

Lynn