Re: Drug Resistance to PI3K Inhibitors

[Guest guest]

One aspect that makes CAL-101 such an attractive agent is

that it does not inhibit the PI3Kinase in breast cancer or

other cells outside of the hematopoietic system. CAL-101

only inhibits the delta isoform, which is not expressed in

solid tumors.

Rick Furman, MD

W.W.WELLS wrote:

/message/16140

[Guest guest]

Thank you Rick for clarification on my previous post. Your

monitoring of this forum makes it the quality place for

CLL/SLL information.

I hope that the central issue, illustrated by the research

of S. Nijman, is not lost on the members by my lack of

knowledge of the precise mechanism of CAL-101 inhibition of

PI3K in blood cancer.

Let us hope that investigations analogous to Nijman's will

be conducted to enhance the understanding of drug resistance

in our camp.

WWW