PCI-32765 monotherapy Clinical Trial end cycle 2 start cycle 3

[Guest guest]

The trip from NY to Columbus began in turmoil as I had

brought my wife by ambulance to Hospital experiencing severe

tachycardia (high heart rate) and I was in arrhythmia upon

leaving. I would have staid at home postponing the scheduled

trip except that my PCI daily meds were at an end and I felt

it would be risking my therapy progression to delay getting

Cycle 3's 28 day supply of capsules. Was this a dumb move on

my part? One always comes away looking like they made the

right decision in the hindsight of getting away with it. My

increasingly frequent arrhythmias are becoming more of a

concern but the risk of stroke is somewhat diminished by my

low platelet count (atta-go CLL) and from previous echo-

cardiogram testing there were no findings of structural

heart damage. I always was a gambler at heart. Sorry - I

never apologize for bad puns.

Upon arrival at the hotel I got some food, ate in the hotel

and went to bed early. At 3:56am I awoke felling sweaty and

hot. On standing, I felt light headed as I walked to the

bathroom. After nearly blacking out my skin turned clammy

and sweat came more easily but I got myself back to the bed

and promptly fell asleep. I awoke at my normal 5:30am time

and surveyed my condition as being pretty good - my pulse

had converted to normal sinus rhythm so I got up had a

shower and because I was due for a CT-scan I decided to walk

to the hospital early since I had to forego the free hotel

breakfast. Curses on the CT-scan requirement.

I have a cell phone in case of emergency and the bike path

is used frequently enough to afford reasonable options for

help if required. Construction on the bridge had now

completely blocked the bike-hike path forcing me to climb a

wooded embankment detouring around the obstacle. Walking to

the hospital just shy of 3miles affords bird watching as the

path follows the Olentangy River into the center of the OSU

medical campus. Because of the proximity of humans to the

habitat of many birds and especially geese I notice their

habits with close-up interest. The guard goose for instance,

how is that particular goose chosen to be the alarm for the

flock that is intent on grazing, preening or sleeping with

complete indifference to threats. Who relieves the guard and

what status does the guard hold with in the flock?

Arriving at the Clinical Trial Unit (CTU) my blood pressure

is exemplary at 117/68 62-heart rate. I am forth coming

about my latest arrhythmia which summons Dr. Byrd. He

suggests that I see a cardiologist at the adjacent Ross

Hospital to which I agree. PCI medication is put on hold for

the day and I am given another echo-cardiogram. Arrangements

are made to be wired up to a monitor for a month once I have

returned home to try and catch the arrhythmia in action.

Echo-cardiogram result comes in late in afternoon but in

time for me to receive my next 28 day supply of meds.

Thoughts of my wife in her situation diminish my own

concerns and somewhat dull the beautiful day as I walk back

to the hotel.

My labs from this monitoring show a surprising rise in the

WBC from 69.7k to 95.1k but consistent with Dr. Byrd's

prediction that I could see my white count go over 100k as

the cancer is pushed out from nodes and marrow. RBC, Hgb, &

Hct are at highest levels since I began PCI. Platelets up

slightly but a disappointing increase in Creatinine at 1.74

with corresponding GFR dropping to 39. This could be the

result of going off Lisinopril because of angioedema.

Losartan was Lisinopril replacement and may take time to be

effective as a nephroprotectant.

My ongoing eye irritation and discharge continues to be a

vexing mystery but I believe it may be associated to the

complement dysregulation speculation for the severe reaction

suffered in March from Rituxan rather than bacterial/viral

infection or purely a histamine release issue.

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