17p deletions post treatment

[Guest guest]

Dr. Furman,

Which scenario do you think is the case, for those who start

treatment without the 17p deletion yet it appears after

treatment:

1) It was there all along .. just outnumbered and out

measured by the deletions that chemo removed .. kind of like

antibiotics that remove everything except the bacteria that

is resistant or

2) The chemo causes a new mutation / deletion that then

multiplies.

or both scenarios??

Thanks

Lynn

[Guest guest]

I suspect it is both. Chemotherapy constantly induces

mistakes in the DNA and then selects for the ones that are

resistant.

Rick Furman

>

> Dr. Furman,

>

> Which scenario do you think is the case, for those who start

> treatment without the 17p deletion yet it appears after

> treatment:

>

> 1) It was there all along .. just outnumbered and out

> measured by the deletions that chemo removed .. kind of like

> antibiotics that remove everything except the bacteria that

> is resistant or

>

> 2) The chemo causes a new mutation / deletion that then

> multiplies.

>

> or both scenarios??

>

> Thanks

> Lynn

>