Hep A/Hep B combo Vax

[Guest guest]

Hey, sterile technique and a sterile hospital room is TOO hard. Let's

vaccinate instead.

The ought to take lessons from computer chip manufacturers for sterile

technique. They can do it for computer chips, why not people?

Sheri

http://www.elsevier.com/inca/publications/store/3/0/5/2/1/

Vaccine, Vol. 19 (9-10) (2000) pp. 1274 - 1283

© 2000 Elsevier Science Ltd. All rights reserved.

PII: S0264-410X(00)00235-8

Comparison of two immunization schedules for a

Pseudomonas aeruginosa outer membrane proteins vaccine

in burn patients

Dong Kun Kim a * gsurgery@..., Jeong Jin Kim a, Jong Hyun Kim a,

Young Min

Woo a, Sung Kim a, Dae Won Yoon a, Chang Sig Choi a, Ik-Sang Kim b, Wan

Je Park c,

Na-Gyong Lee c, Sang Bo Jung c, Bo Young Ahn c, Sung Woo Nam c, Suk Min

Yoon c and

Won Jung Choi c

a Hangang Sacred Heart Hospital, School of Medicine, Hallym University,

Youngdungpo-ku, Seoul

150-020, South Korea

b Clinical Pharmacology Unit, College of Medicine, Seoul National

University, SNUH, Seoul 110-799,

South Korea

c R & D Center of Bioscience, Institute of Science and Technology,

CheilJedang Corporation, Ichon,

Kyonggi 467-810, South Korea

Received 5 April 2000; received in revised form 5 June 2000;

accepted 6 July 2000

Abstract

The aim of the present study was to compare two immunization schedules for

a Pseudomonas

aeruginosa outer membrane proteins (OMPs) vaccine in burn patients. In a

double-blind,

randomized and placebo-controlled clinical trial, 95 adult patients with

burn injuries in 10% or greater

of total body surface area were randomly allocated to either placebo or

immunization groups. Three

doses of the vaccine (0.5 or 1.0 mg) were administered intramuscularly at

either 3- or 7-day

intervals. The vaccine was well tolerated, and no severe adverse reactions

were observed in any of

the vaccinees. After three immunizations, 88 patients were available for

evaluation of serum antibody

titers. Elevation of OMPs-specific antibody titers in the immunization

groups was significantly higher

as compared with the placebo group, and the highest antibody response was

obtained by

immunization with 1.0-mg doses at 3-day intervals. Conventional blood

culture, tissue culture of

wound biopsy specimens and a nested polymerase chain reaction (PCR) assay

of blood specimens

were performed to determine the protective efficacy. The results of the

nested PCR indicated that

the overall detection rate of P. aeruginosa in blood was significantly

lower among immunized

patients than placebo patients (6.1 vs. 40.0%, P<0.001). Based on these

results, we concluded that

the P. aeruginosa OMPs vaccine is safe and highly immunogenic in burn

patients, especially with

1.0-mg doses at 3-day intervals, and may be effective in conferring

protection against P. aeruginosa

bacteremia in burn patients.

Keywords: Pseudomonas aeruginosa vaccine; Burn patient; Clinical trial;

Immunization schedule

*Corresponding author. Tel.: +82-2-26395442; fax: 82-2-6784386

[Full text] (PDF 115.4 Kb)

© Copyright 2000, Elsevier Science, All rights reserved.

--------------------------------------------------------

Sheri Nakken, R.N., MA

Vaccination Information & Choice Network, Nevada City CA

530-272-7306

http://www.nccn.net/~wwithin/vaccine.htm

" All that is necessary for the triumph of evil is that good men ( &

women) do nothing " ...Edmund Burke

ANY INFO OBTAINED HERE NOT TO BE CONSTRUED AS MEDICAL OR LEGAL ADVICE. THE

DECISION TO VACCINATE IS YOURS AND YOURS ALONE.

Well Within's Earth Mysteries & Sacred Site Tours

http://www.nccn.net/~wwithin

International Tours, Homestudy Courses, ANTHRAX & OTHER Vaccine Dangers

Education, Homeopathic Education

KVMR Broadcaster/Programmer/Investigative Reporter, Nevada City CA

CEU's for nurses, Books & Multi-Pure Water Filters

[Guest guest]

wow--they tested a whole 100 people with a whole 4 day follow up--good solid medical study, wouldn't you say? (NOT!!!!!!)

brigit