Guest guest Posted October 27, 2006 Report Share Posted October 27, 2006 Hi Pam, PCRU stands for PCR Undetectable meaning that when they do the PCR test, they find no bcr/abl transcripts. A good PCR test will look at least 100,000 cells so if you're zero on that test, you're doing very well indeed, it would be a complete molecular response. Doctors don't typically use the word " remission " because it's misleading. In other cancers, the term remission infers that the cancer is gone and is no longer active whereas with us, we know that the cancer is still there, it's just at a very low level and is being kept under control with Gleevec. With CML, doctors usually use the word " response " meaning the patient has had a response. There are also different levels of responses. Firstly we have a hematological response meaning that our blood counts have returned to normal. Next is the cytogenetic response which means that our bone marrow appears normal with normal chromosomes and finally there's a molecular response which is what the PCR measures. A FISH test only looks at about 200 cells so although it can give you some idea of what your status is, the PCR test is really what you want to have to track your molecular response. Most of us never reach a zero on a PCR test, the best we can hope for is a 3 log reduction which would qualify as a " major molecular response " . I hope that helps, Tracey dx Jan 2002 -- In , " pmiller789 " <pmiller789@...> wrote: > > Will someone explain what PCRU is? I'm thinking it's remission. I get > the results of my FISH on Monday. If it's 0% am I PCRU? And what is > the technical name. > Thanks. > Pam > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 28, 2006 Report Share Posted October 28, 2006 Dear Everyone: I am delighted to say that Dr. Druker's office just emailed me that I am still PCRU! So, the saga continues with the Gleevec level. I do not want to bore anyone. I am on 300 mg of Gleevec and it is thought that once the PK Gleevec levels are taken again and if they still show high, I will be reduced one more time to 300 one day, and 200 the next day. Then in three months, another level will be assessed and then depending on that level, I may be reduced to 200 mg...and that will be that! Along with constanct PCR testing via blood samples. So, I am in a relatively estatic mood right now! Hugs, Rosenthal Miami, Florida dx January 8, 2003 PCRU since October 2004!!! Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 14, 2008 Report Share Posted March 14, 2008 - congratulatios and may it continue to get better, gleevec rocks aliza yaffa rochester n.y. -- In , " Marcos Perreau Guimaraes " <montereyunderwater@...> wrote: > > I just got my hemato on the phone for the last PCR results and, > finally, after 3 years short of MMR and being called names like > suboptimal, I am now PCRU. That was quite a surprise, I was hoping > that maybe I d get to the 3 log reduction this time (2.8 four months > ago), but PCRU is about 2 log (100 fold) down from 2.8 with the > sensitivity of Stanford lab. It looks like somewhere during these 4 > months the bug lost a big battle. > Here a bit of what happened since dx : > Dx march 2005 BMB 20/20 ph+, FISH 100% ph+, WBC 252, spleen the size > of a melon, 135 lbs for 6'2 (I am in general at 175-180) > about 10 days hydrea, then gleevec 400 mg/day > Hematologic remission in 2-3 weeks, cleared to dive one month after > September 2005, BMB 0/20 ph+, FISH 7% > March 2006, BMB 0/20, FISH 0% > I don't have all the numbers at the office but I had a pcr every 4 > months since and for one year (to about march 2007) it stayed around > 2.6 log reduction. At that point I saw a cml specialist in Paris that > did a dosage of gleevec in the plasma and it was a little low, about > 600 when the optimal value is 1000. She said she advised her patients > in my case to change to 600mg of gleevec but I wasn't too hot about > that as I was afraid that with more side effects than I have now I > wouldn't be able to endure the long 2h+ decompression stops of the > deep dives. She understood my reasons and advised to wait and see for > a couple of pcr tests. The next PCR had a 2 fold reduction to about > -2.7 log, and the next was at -2.8 log. So I stayed on 400mg. And this > morning PCRU. > Marcos. > > > Marcos Perreau Guimaraes > Suppes Brain Lab > Ventura Hall - CSLI > Stanford University > 220 Panama street > Stanford CA 94305-4101 > 650 614 2305 > 650 630 5015 (cell) > marcospg@... > montereyunderwater@... > www.stanford.edu/~marcospg/ > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 14, 2008 Report Share Posted March 14, 2008 Hi Marcos, That is great news, but I would still want to see the next result to confirm your PCRU. You need 2 or 3 consecutive results to establish a trend. Zavie Zavie (age 69) 67 Shoreham Avenue Ottawa, Canada, K2G 3X3 dxd AUG/99 INF OCT/99 to FEB/00, CHF No meds FEB/00 to JAN/01 Gleevec since MAR/27/01 (400 mg) CCR SEP/01. #102 in Zero Club 2.8 log reduction Sep/05 3.0 log reduction Jan/06 2.9 log reduction Feb/07 3.2 log reduction Jun/07 3.6 log reduction Sep/07 3.5 log reduction Feb/08 e-mail: zmiller@... Tel: 613-726-1117 Fax: 309-296-0807 Cell: 613-202-0204 ID: zaviem YM: zaviemiller Skype: Zavie _____ From: [mailto: ] On Behalf Of Marcos Perreau Guimaraes Sent: March 14, 2008 3:04 PM Subject: [ ] PCRU I just got my hemato on the phone for the last PCR results and, finally, after 3 years short of MMR and being called names like suboptimal, I am now PCRU. That was quite a surprise, I was hoping that maybe I d get to the 3 log reduction this time (2.8 four months ago), but PCRU is about 2 log (100 fold) down from 2.8 with the sensitivity of Stanford lab. It looks like somewhere during these 4 months the bug lost a big battle. Here a bit of what happened since dx : Dx march 2005 BMB 20/20 ph+, FISH 100% ph+, WBC 252, spleen the size of a melon, 135 lbs for 6'2 (I am in general at 175-180) about 10 days hydrea, then gleevec 400 mg/day Hematologic remission in 2-3 weeks, cleared to dive one month after September 2005, BMB 0/20 ph+, FISH 7% March 2006, BMB 0/20, FISH 0% I don't have all the numbers at the office but I had a pcr every 4 months since and for one year (to about march 2007) it stayed around 2.6 log reduction. At that point I saw a cml specialist in Paris that did a dosage of gleevec in the plasma and it was a little low, about 600 when the optimal value is 1000. She said she advised her patients in my case to change to 600mg of gleevec but I wasn't too hot about that as I was afraid that with more side effects than I have now I wouldn't be able to endure the long 2h+ decompression stops of the deep dives. She understood my reasons and advised to wait and see for a couple of pcr tests. The next PCR had a 2 fold reduction to about -2.7 log, and the next was at -2.8 log. So I stayed on 400mg. And this morning PCRU. Marcos. Marcos Perreau Guimaraes Suppes Brain Lab Ventura Hall - CSLI Stanford University 220 Panama street Stanford CA 94305-4101 650 614 2305 650 630 5015 (cell) marcospgcsli (DOT) <mailto:marcospg%40csli.stanford.edu> stanford.edu montereyunderwater@ <mailto:montereyunderwater%40gmail.com> gmail.com www.stanford.edu/~marcospg/ Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 16, 2008 Report Share Posted March 16, 2008 Congratulation!!!!!! Marcos we are all so happy for you. Chi --- Marcos Perreau Guimaraes <montereyunderwater@...> wrote: > I just got my hemato on the phone for the last PCR > results and, > finally, after 3 years short of MMR and being called > names like > suboptimal, I am now PCRU. That was quite a > surprise, I was hoping > that maybe I d get to the 3 log reduction this time > (2.8 four months > ago), but PCRU is about 2 log (100 fold) down from > 2.8 with the > sensitivity of Stanford lab. It looks like somewhere > during these 4 > months the bug lost a big battle. > Here a bit of what happened since dx : > Dx march 2005 BMB 20/20 ph+, FISH 100% ph+, WBC 252, > spleen the size > of a melon, 135 lbs for 6'2 (I am in general at > 175-180) > about 10 days hydrea, then gleevec 400 mg/day > Hematologic remission in 2-3 weeks, cleared to dive > one month after > September 2005, BMB 0/20 ph+, FISH 7% > March 2006, BMB 0/20, FISH 0% > I don't have all the numbers at the office but I had > a pcr every 4 > months since and for one year (to about march 2007) > it stayed around > 2.6 log reduction. At that point I saw a cml > specialist in Paris that > did a dosage of gleevec in the plasma and it was a > little low, about > 600 when the optimal value is 1000. She said she > advised her patients > in my case to change to 600mg of gleevec but I > wasn't too hot about > that as I was afraid that with more side effects > than I have now I > wouldn't be able to endure the long 2h+ > decompression stops of the > deep dives. She understood my reasons and advised to > wait and see for > a couple of pcr tests. The next PCR had a 2 fold > reduction to about > -2.7 log, and the next was at -2.8 log. So I stayed > on 400mg. And this > morning PCRU. > Marcos. > > > Marcos Perreau Guimaraes > Suppes Brain Lab > Ventura Hall - CSLI > Stanford University > 220 Panama street > Stanford CA 94305-4101 > 650 614 2305 > 650 630 5015 (cell) > marcospg@... > montereyunderwater@... > www.stanford.edu/~marcospg/ > ________________________________________________________________________________\ ____ Never miss a thing. Make your home page. http://www./r/hs Quote Link to comment Share on other sites More sharing options...
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