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UK CLEAR trial

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CLEAR: CLL Empirical Antibiotic Regimen - A phase II trial

of broad spectrum antibiotic therapy for early stage, non-

progressive chronic lymphocytic leukaemia without adverse

prognostic factors

This phase II trial is testing the use of antibiotics for

patients with chronic lymphocytic leukaemia who have

received no prior treatment. Patients will receive a short

but intensive course of antibiotics, to help control the

symptoms of their disease, early on. This national trial is

being run by Dr Devereux at King's College London.

Does anyone have any links to studies or research documents

explaining the rationale? Or other studies/trials in this

area that have been carried out.

My limited understanding is that the trial is effectively

investigating if infection drives CLL progression during the

earlier stages of the disease?..

Nick (UK)

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