Common genetic variation contributes to the risk of developing CLL and ALL

[Guest guest]

This paper by Sherborne and Houlston of the Institute of Cancer Research in the

UK

Houlston has been furthered our knowledge of genetic markers in CLL by his study

of generic risk markers.

This paper looks at common genetic variations of both CLL and ALL...

" Genome- wide association studies (GWAS) have provided the first unambiguous

evidence that common genetic variation contributes to the risk of developing CLL

and ALL and implicate genes involved in transcriptional regulation and

differentiation of B-cell progenitors as the biological basis of predisposition

to B-cell malignancy.

Furthermore, their identification provides novel insight into disease causation

of these two major haematological malignancies. "

FULL PAPER PDF:

http://impactjournals.com/oncotarget/papers/v1/n5/pdf/100904.pdf