State of the art research in CLL right now?

[Guest guest]

Now that we've entered the world of CAL-101 and PCI 32724,

what does the future hold regarding further directions in

CLL research?

Mark

[Guest guest]

Much more of the same from larger companies with more

money...slightly different targets eg: AKT-mTOR

Hopefully a Phase III clinical trial in a couple of

years...for CAL101 etc

ROR1, CLLU1, CD19 targeted monoclonals, insulin receptor,

CLL/stromal, STAT3, understanding the microenvironment

better, siRNAs, development of vaccines, new drug

combinations, use of T cells to fight CLL, better CD20

monoclonals, selectively targeting of malignant B-cells,

understand genetic abnormalities and their effect...

Higher resolution gene analysis and mapping...

Replacement of FISH with aCGH, p53 AmpliChip

Finding a control or cure...

I'm sure others can add much more...

~chris