VEGF secretion by CLL cells

[Guest guest]

Hi All,

Perhaps some of the experts can help me?

I understand a little about the evidence of the importance

of VEGF (vascular endothelial growth factor) in CLL, and

that it may be a good therapeutic target for treatment of

the disease. Because of its role in stimulating PKCâ

expression and VEGF is implicated as a factor contributing

to the anti apoptopic survival loop in CLL cells.

For me as a patient this highlights the significance of me

considering trying EGCG capsules. I have not heard so much

about green tea extracts recently. EGSG's apparent ability

to induce apoptotic cell death in CLL cells, through its

effects on the VEGF receptor being the route of this

therapy. Is this only effective in early CLL?

Higher levels of over expression of VEGF appear to be

associated with CLL cells with CD38+ and unmutated IGVH

genes. There are many potential physical effects to VEGF

over expression. Does the EGCG extract have any effect on

reducing the consequences of this over expression on other

cell lines/ body functions?

Are there any papers discussing the long term physical

effect of VEGF over expression in CLL patients?

Much of my understanding on this topic has come from

Professor Hamblin's writings in his blog;

http://mutated-unmuated.blogspot.com

Kind regards

Nick (UK)

Trisomy 12, CD38+,unmutated