FCM + Rituxan better than FCM

[Guest guest]

Study in British Journal of Haematology.

26 CLL previously treated patients in FCM (Fludarabine, Cyclophosphimide and

mitoxantrone) arm and 26 in the FCM + Rituxan arm I

ORR was FCM - 58%.

FCM + R - 65%

CR and CR (incomplete marrow response) - FCM - 15%. FCM+R - 42%

MRD negativity (3 FCM; 5 FCM-R)

Conclusions:

" The toxicity of both regimens was acceptable. In conclusion, the addition of

rituximab to FCM improves the response rates in relapsed CLL, resulting in more

complete remissions and without additional safety concerns. Efficacy and safety

should be fully tested in a randomized Phase III trial. "

Source:

http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2141.2010.08317.x/abstract

Rituxan has synergistic effect...

~chris

CLL CANADA