Closed CAL 101 trials for CLL

[Guest guest]

Hi, Need some help. My wife is being treated for CLL relapsed 3rd time. Just

finished 8 weeks of Arzerra and will start monthly infusions soon. She has BM

and CT scans scheduled next week. We know BM will still show significant

presence of CLL since % of lymphs high in todays CBC. Thinking ahead , called

Ohio State to ask if any openiings in their CAL 101 study. I was told since the

trial added amendments 8 & 9 to the protocol that there were no trials phase 1

trials for CLL that were still active. I informed her that gov. clinical trail

website still listed Ohio State and others that were still recruiting CLL

patients. I was told that website is not updating regularly and only NHL

patients were receiving CAL 101 in stuidies. Called Calistoga, but have not

received a phone call back.

Does anyone know if this info is correct. She has done FCR twice and we were

hoping to get a remission with Arzerra and if not, travel to a clinical study

with CLL. Registered with for SCT 6 months ago, but so far no 10 point

matches found.

Thanks,

Hal

[Guest guest]

The CAL-101 plus ofatumumab part of the trial (CAL-101-07 study) should be

opening in two months. There will likely be similar trials with PCI-32765

opening in 4-6 months as well.

Rick Furman, MD

>

> Hi, Need some help. My wife is being treated for CLL relapsed 3rd time. Just

finished 8 weeks of Arzerra and will start monthly infusions soon. She has BM

and CT scans scheduled next week. We know BM will still show significant

presence of CLL since % of lymphs high in todays CBC. Thinking ahead , called

Ohio State to ask if any openiings in their CAL 101 study. I was told since the

trial added amendments 8 & 9 to the protocol that there were no trials phase 1

trials for CLL that were still active. I informed her that gov. clinical trail

website still listed Ohio State and others that were still recruiting CLL

patients. I was told that website is not updating regularly and only NHL

patients were receiving CAL 101 in stuidies. Called Calistoga, but have not

received a phone call back.

> Does anyone know if this info is correct. She has done FCR twice and we were

hoping to get a remission with Arzerra and if not, travel to a clinical study

with CLL. Registered with for SCT 6 months ago, but so far no 10 point

matches found.

> Thanks,

> Hal

>

>

>

[Guest guest]

This sounds extremely interesting. Will these combo trials be phase II and ..

can we get a hint as to which cancer centers may offer them or is that already

on the .gov website?

Also would love to hear a subjective comparison of PCI-32765 and CAL-101 at this

point .. what are the best targets or patient groups for each, knowing it is

early days for both biologics.

Thanks

Lynn

>