Gleevec may be useful as an antiosteolytic agent -

[Guest guest]

He Everyone,

Quite some time ago I posted an abstract that showed how Gleevec

inhibited c-fms but at the time, this implication wasn't well

understood.

In the past we've seen concerns that Gleevec may negatively impact

bone development especially in those who tend to be low on phosphorus

but this article seems to indicate that Gleevec can be useful to

treat various bone diseases such as osteoporosis, metastatic bone

disease, and multiple myeloma because of the fact that it inhibits

this enzyme called c-fms.

I hope will be able to " translate " this article for us so

that we can understand it better.

http://www.bloodjournal.org/cgi/content/abstract/107/11/4334?

maxtoshow= & HITS=10 & hits=10 & RESULTFORMAT= & fulltext=imatinib & searchid=1 &

FIRSTINDEX=0 & sortspec=relevance & resourcetype=HWCIT

Tracey

PS- In case the link doesn't work, the title of the article is

" Imatinib as a potential antiresorptive therapy for bone disease " and

I found it in Blood, 1 June 2006, Vol. 107, No. 11, pp. 4334-4337.