Guest guest Posted January 9, 2007 Report Share Posted January 9, 2007 -- I am a member to this forum since my husband was diagnosed with CML in July of 2006. I read often and post seldom---but had to write and say THANK YOU for this glossary....wow, some of us really needed that! Thanks much, Cervera >From: " Tracey " <traceyincanada@...> >Reply- > >Subject: [ ] CML Glossary >Date: Tue, 09 Jan 2007 02:39:02 -0000 > >Hi Everyone, > >We've had a number of new members join recently so I thought now >might be a good time to post a review of the CML jargon we often >use. For those who might be getting lost in the alphabet soup, I've >copied and pasted the Glossary we have in the files section that > did for us a few years ago. I've shortened it here to >include just the more common terms we use. If anyone wants to see >the longer version, you can access it in the files section on the >left of the screen. > >Please don't hesitate to ask any questions. > >Take care, >Tracey >dx Jan 2002 > > > >ABL = a gene (named for a researcher whose last name was Abelson) on >human chromosome # 9, involved in normal white blood cell >replication. Abl only causes trouble when it leaves to join >chromosome #22, creating the bcr-abl gene. (See bcr-abl) > >Absolute neutrophil count = the total number of neutrophil cells per >microliter of blood. It is calculated by using the total white blood >count (WBC) and the percentage of neutrophils shown on the >laboratory " differential. " > >ALT = alanine aminotransferase: a blood test used to detect liver >inflammation (see AST) > >ANC = absolute neutrophil count > >ASH = American Society of Hematologists > >AST = aspartate aminotransferase: a blood test used to detect liver >inflammation (see ALT). > >Basophil = a type of myeloid white blood cell which is often elevated >in CML > >Bcr = breakpoint cluster region – a gene on human chromosome # 22 >which is involved in the pathophysiology (abnormal functioning) of >CML > >bcr-abl = the abnormal gene that characterizes the leukemic stem >cells of most people with CML. For CML to occur, the " abl " gene >(named after a researcher named Abelson) must come unglued from its >usual location on chromosome # 9, and become attached to the " bcr " >(breakpoint cluster region) of chromosome #22, thus creating the bcr- >abl hybrid, or " chimera " which has a number of nasty properties. It >appears that the genetic " mistake " producing bcr-abl is quite common >and may occur several times during the lives of normal people; >however, their immune systems recognize and kill the abnormal cells. >This fails to happen in people who develop CML, but it's not known >why. > >BMA = bone marrow aspiration--a procedure in which liquid contents of >a patient's bone marrow are withdrawn (aspirated) through a needle. >This procedure is used to make the diagnosis and to follow the >progress of treatment of CML. > >BMB = bone marrow biopsy--similar to a bone marrow aspiration, but >used less frequently and performed with slightly different >equipment. It is used when a larger or different kind of sample of >marrow is needed, or when a BMA is unsuccessful because the marrow is >too fibrous to permit aspiration through the BMA needle. > >BMT = bone marrow transplant > >Bone marrow = the central portion of our bones, where the majority of >blood cells types are made and stored. Bone marrow contains many >other types of tissue besides blood cells, including a fine meshwork >of bone ( " spicules " ), connective tissue, and blood vessels. > >Bone marrow transplant (BMT) = a procedure in which bone marrow is >taken from one person and given to another, for therapeutic >purposes. In fact, this procedure is rarely used nowadays, having >been largely replaced by stem cell transplants (SCT's); however, many >people still use the term BMT even when they're referring to an SCT. > >BUN = Blood Urea Nitrogen (a measure of kidney function) > >CBC = complete blood count-- a blood test that measures the >proportions and total number of white blood cells, red blood cells, >and platelets. It also gives information concerning the shape, size >and variation of these cells. In CML a " white cell differential " is >usually performed along with the CBC. This tells which of several >kinds of white cells are present, and in what proportion. > >CCR = complete cytogenetic response--absence of leukemic (Ph+) cells >in the bone marrow by either conventional or FISH cytogenetic testing. > >CHF = Congestive heart failure > >Chromosome - in a cell nucleus, a structure containing a molecule of >DNA that transmits genetic information . Each organism of a species >normally has a characteristic number of chromosomes in its somatic >cells; the normal number for humans is 46. The chromosomal mutation >leading to CML involves chromosomes number 9 and 22 - though if the >disease is untreated, other chromosomal abnormalities accumulate as >well. This process is called clonal evolution. > >Chronic myelogenous leukemia (CML) = a disease involving the >overproduction of certain types of white ( " myeloid " ) blood cells. >Untreated, CML progresses through three phases – chronic; >accelerated; and acute, or blastic phase – each of which is shorter >and harder to treat than the last. Also called chronic " myeloid " >or " myleocytic, " or " granulocytic " leukemia > >Clonal evolution = the accumulation of DNA (chromosome) mutation >which occurs in untreated CML, and which leads to progression of the >disease. > >Cytogenetics. Cyto = cell; genetics refers to looking at the cells >chromosomes, their genetic material. Two types of >cytogenetics, " conventional " and FISH, are used to diagnose and >follow the course of CML. Conventional cytogenetics (so called >because it's been around a long time) is a microscopic exam of up to >25 marrow cells in a phase of cell division when their chromosomes >can be clearly seen and differentiated. > >Cytogenetic response (CR) is a response to treatment of CML that >occurs in the marrow, rather than just in the blood..... There are 3 >levels of cytogenetic response: 1) just plain cytogenetic response >(CR); 2) Major cytogenetic response (MCR); and 3) complete >cytogenetic response (CCR). A plain cytogenetic response means any >Ph+ less than you began with; major means 35% or less, but more than >0%; and complete cytogenetic response means 0% Ph+ cells as measured >by either conventional or FISH cytogenetic testing (though the PCR >test may still be positive). > >DNA = Molecule that carries genetic information. The DNA is >assembled into discrete packets called chromosomes. Humans have 23 >pairs of chromosomes, or 46 of them, total, in each cell. > >Donor Leukocyte Infusion (DLI) - a procedure done for relapsed >SCTs. Immune system cells are taken from the original donor and >transfused to the CML patient. > >Dx = abbreviation for " diagnosis " > >Enzyme = a protein that catalyzes changes in other biological >substances. Too many white cells are produced in CML because of an >abnormal tyrosine kinase enzyme - whose sole activity is sticking >phospate molecules onto tyrosine molecules. It's hard to imagine >that so much mischief could be caused by such a simple act! > >Fluorescence In Situ Hybridization (FISH) - a cytogenetic test that >is used to reveal the presence of the " bcr-abl " gene. The abl DNA >shows up as a red dot in the microscope slide and bcr DNA shows as a >green dot (see http://path.upmc.edu/cases/case171/mole.html for a >nice picture). In the nuclei of normal cells, where abl and bcr are >on different chromosomes, these dots appear separately. But in Ph+ >leukemic cells where bcr and abl are fused, the dots appear >together. If you see RedGreen the cell is Ph+, while Red-------Green >(that is, they're far apart) is Ph-, normal. Clever, huh? > >G-CSF = granulocyte colony stimulating factor (brand name Neupogen) = >a naturally occurring hormone that stimulates white blood cell >production > >Graft vs. host disease (GVHD) = a collection of ailments that >complicate stem cell (bone marrow) transplantation. In GVHD, the >donor's immune system (the " graft " ) attacks various of the patient's >(the host's) tissues. > >Hematologic response = normalization of the white blood cell counts >in the blood, though not necessarily in the bone marrow. The response >can be partial (reduction in white cells, but not down to normal >range) or complete (white blood count at or below approximately >12,000 white cells/microliter) > >Hydrea (hydroxyurea, HU) = a chemotherapy drug which is often used >first in the treatment of CML. Lethal to mature leukemic cells >Hydrea can bring elevated white blood counts (WBCs) back to normal; >however, it does not kill many leukemic stem cells in the bone >marrow, and therefore does not effectively slow the progression of >the disease. > >IFN = interferon > >IM – imatinib mesylate, the brand name for Gleevec (Glivec, outside >the US and Canada) > >LAP = leukocyte alkaline phosphatase: a chemical produced in high >quantities in certain leukemias, but always low in chronic phase CML. >A low serum LAP is thus used to support the diagnosis of CML. > >LD (or LDH) = Lactate dehydrogenase = an enzyme produced by certain >cell and tissue types. It is used to help diagnose CML " blast " >phase, since blasts produce LDH in abnormally high quantities. > >Leukemia = cancer of the white blood cells. Leukemia literally >means " white blood " (leukos = white, and –emia.) > >Leukocyte = white blood cell (leukos = white; cytos = cell in >Greek). The main types of leukocytes are neutrophils, lymphocytes, >monocytes, basophils, and eosinophils. > >LLS = Leukemia & Lymphoma Society > >Lymphocyte = a type of white blood cell generally not involved in >CML. Two main types of lymphocytes are B-Cells and T-Cells. > >Mini-transplant = non-myeloablative stem cell transplant (mini- >transplant) - a type of stem cell transplant in which the patient's >marrow (myelo-) is not destroyed (ablated) prior to the transplant >procedure > >Minimal residual disease = a term used where bcr-abl is still >detectable by PCR, but cytogenetics are negative, or nearly so. > >Molecular response (aka PCRU) = defined as a negative PCR or other >negative molecular test. > >Myelofibrosis = replacement of blood stem cells in the bone marrow >with fibrous tissue. Myelofibrosis occurs as a complication of CML >and of its treatments, especially interferon. > >Myeloproliferative disorder (MPD) = a family of diseases involving >the overproduction of one or another marrow cell types. CML is a >myeloproliferative disorder. > >Neutrophils = the type of myeloid white blood cell which is most >increased in CML. Also referred to as polys (polymorphoneuclear >neutrophils); granulocytes (though this term also includes other >types of white cells, such as basophils and eosinophils); and neuts. > >PEG-IFN = pegyllated interferon: interferon (IFN) that has PEG >(PolyEthylene Glycol) molecules attached to it. PEG gives IFN a >longer half-life in the body, and may reduce the drug's toxicity and >increase its effectiveness. > >Ph = Philadelphia Chromosome. > >Ph+ and Ph- refer to the presence and absence, respectively, of the >Philadelphia chromosome in white blood cells of CML patients. The >proportion of Ph+ to Ph- cells is used to track progress in treating >the disease: anything less than you started with is called a >Cytogenetic Response (CR); 35% or less Ph+ is a Major Cytogenetic >Response (MCR), and 0% Ph+ is a Complete Cytogenetic Response (CCR). > >Philadelphia chromosome (Ph) is a term used to describe the abnormal >appearance certain chromosomes (chromosome #22), in dividing white >blood cells found in 95% of people who have CML. The Philadelphia >chromosome results from a mutation that involves the swapping of >genetic material between chromosome # 9 and chromosome #22 (see bcr- >abl) > >Phillies = abbreviation for philadephia chromosome positive (Ph+) >cells, coined by members of the CML list. > >Polymerase Chain Reaction (PCR) test = a very sensitive test which >can be used to detect the presence of very low levels of specific >genetic material (DNA). It is used to detect, and sometimes to >quantify, bcr-abl in bone marrow cells of patients with CML. The >most sensitive PCR tests can detect as few as on in 100,000,000 >cells. For an explanation of how PCR works, see >http://www.scientific.org/tutorials/articles/riley/riley.html > >Procrit = a brand name for artifically produced erythropoietin, a >hormone that stimulates red blood cell production. > >Stem Cell Transplant (SCT; previously known as bone marrow transplant >or BMT - these terms and abbreviations are used interchangeably, but >SCT is technically more correct) = a procedure in which the patient's >marrow cells are replaced with a donor's marrow cells in hopes of >curing a disease. > >Translocation = where a bit of genetic material from one chromosome >(humans have a total of 46 chromosomes) is swapped with a bit from >another chromosome. In CML, a piece (called " abl " ) from chromosome # >9 is swapped onto a segment (called " bcr " ) on chromosome #22 to >create the " bcr-abl oncogene " that causes this disease. > >Tyrosine Kinase = an enzymes involved in many kinds of communication >within cells. The bcr-abl gene codes for an abnormal tyrosine kinase >that causes much of the mischief in CML. > >WBC = white blood count – the number of white blood cells in a sample >of blood. > >Zero Club = a term coined by members of the CML list-serve (Zavie >, actually) to refer to patients who have achieved 0% PH+ > > > > > _________________________________________________________________ Get live scores and news about your team: Add the Live.com Football Page www.live.com/?addtemplate=football & icid=T001MSN30A0701 Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 10, 2007 Report Share Posted January 10, 2007 Tracey thank you so much for all your information I was dx on Oct.06. and I don't post to much but I read everything everyone posts I am thankfull and greatfull for all of you it takes some of the fear of the unknown away . THANKS AGAIN Esther > > Hi Everyone, > > We've had a number of new members join recently so I thought now > might be a good time to post a review of the CML jargon we often > use. For those who might be getting lost in the alphabet soup, I've > copied and pasted the Glossary we have in the files section that > did for us a few years ago. I've shortened it here to > include just the more common terms we use. If anyone wants to see > the longer version, you can access it in the files section on the > left of the screen. > > Please don't hesitate to ask any questions. > > Take care, > Tracey > dx Jan 2002 > > > > ABL = a gene (named for a researcher whose last name was Abelson) on > human chromosome # 9, involved in normal white blood cell > replication. Abl only causes trouble when it leaves to join > chromosome #22, creating the bcr-abl gene. (See bcr-abl) > > Absolute neutrophil count = the total number of neutrophil cells per > microliter of blood. It is calculated by using the total white blood > count (WBC) and the percentage of neutrophils shown on the > laboratory " differential. " > > ALT = alanine aminotransferase: a blood test used to detect liver > inflammation (see AST) > > ANC = absolute neutrophil count > > ASH = American Society of Hematologists > > AST = aspartate aminotransferase: a blood test used to detect liver > inflammation (see ALT). > > Basophil = a type of myeloid white blood cell which is often elevated > in CML > > Bcr = breakpoint cluster region – a gene on human chromosome # 22 > which is involved in the pathophysiology (abnormal functioning) of > CML > > bcr-abl = the abnormal gene that characterizes the leukemic stem > cells of most people with CML. For CML to occur, the " abl " gene > (named after a researcher named Abelson) must come unglued from its > usual location on chromosome # 9, and become attached to the " bcr " > (breakpoint cluster region) of chromosome #22, thus creating the bcr- > abl hybrid, or " chimera " which has a number of nasty properties. It > appears that the genetic " mistake " producing bcr-abl is quite common > and may occur several times during the lives of normal people; > however, their immune systems recognize and kill the abnormal cells. > This fails to happen in people who develop CML, but it's not known > why. > > BMA = bone marrow aspiration--a procedure in which liquid contents of > a patient's bone marrow are withdrawn (aspirated) through a needle. > This procedure is used to make the diagnosis and to follow the > progress of treatment of CML. > > BMB = bone marrow biopsy--similar to a bone marrow aspiration, but > used less frequently and performed with slightly different > equipment. It is used when a larger or different kind of sample of > marrow is needed, or when a BMA is unsuccessful because the marrow is > too fibrous to permit aspiration through the BMA needle. > > BMT = bone marrow transplant > > Bone marrow = the central portion of our bones, where the majority of > blood cells types are made and stored. Bone marrow contains many > other types of tissue besides blood cells, including a fine meshwork > of bone ( " spicules " ), connective tissue, and blood vessels. > > Bone marrow transplant (BMT) = a procedure in which bone marrow is > taken from one person and given to another, for therapeutic > purposes. In fact, this procedure is rarely used nowadays, having > been largely replaced by stem cell transplants (SCT's); however, many > people still use the term BMT even when they're referring to an SCT. > > BUN = Blood Urea Nitrogen (a measure of kidney function) > > CBC = complete blood count-- a blood test that measures the > proportions and total number of white blood cells, red blood cells, > and platelets. It also gives information concerning the shape, size > and variation of these cells. In CML a " white cell differential " is > usually performed along with the CBC. This tells which of several > kinds of white cells are present, and in what proportion. > > CCR = complete cytogenetic response--absence of leukemic (Ph+) cells > in the bone marrow by either conventional or FISH cytogenetic testing. > > CHF = Congestive heart failure > > Chromosome - in a cell nucleus, a structure containing a molecule of > DNA that transmits genetic information . Each organism of a species > normally has a characteristic number of chromosomes in its somatic > cells; the normal number for humans is 46. The chromosomal mutation > leading to CML involves chromosomes number 9 and 22 - though if the > disease is untreated, other chromosomal abnormalities accumulate as > well. This process is called clonal evolution. > > Chronic myelogenous leukemia (CML) = a disease involving the > overproduction of certain types of white ( " myeloid " ) blood cells. > Untreated, CML progresses through three phases – chronic; > accelerated; and acute, or blastic phase – each of which is shorter > and harder to treat than the last. Also called chronic " myeloid " > or " myleocytic, " or " granulocytic " leukemia > > Clonal evolution = the accumulation of DNA (chromosome) mutation > which occurs in untreated CML, and which leads to progression of the > disease. > > Cytogenetics. Cyto = cell; genetics refers to looking at the cells > chromosomes, their genetic material. Two types of > cytogenetics, " conventional " and FISH, are used to diagnose and > follow the course of CML. Conventional cytogenetics (so called > because it's been around a long time) is a microscopic exam of up to > 25 marrow cells in a phase of cell division when their chromosomes > can be clearly seen and differentiated. > > Cytogenetic response (CR) is a response to treatment of CML that > occurs in the marrow, rather than just in the blood..... There are 3 > levels of cytogenetic response: 1) just plain cytogenetic response > (CR); 2) Major cytogenetic response (MCR); and 3) complete > cytogenetic response (CCR). A plain cytogenetic response means any > Ph+ less than you began with; major means 35% or less, but more than > 0%; and complete cytogenetic response means 0% Ph+ cells as measured > by either conventional or FISH cytogenetic testing (though the PCR > test may still be positive). > > DNA = Molecule that carries genetic information. The DNA is > assembled into discrete packets called chromosomes. Humans have 23 > pairs of chromosomes, or 46 of them, total, in each cell. > > Donor Leukocyte Infusion (DLI) - a procedure done for relapsed > SCTs. Immune system cells are taken from the original donor and > transfused to the CML patient. > > Dx = abbreviation for " diagnosis " > > Enzyme = a protein that catalyzes changes in other biological > substances. Too many white cells are produced in CML because of an > abnormal tyrosine kinase enzyme - whose sole activity is sticking > phospate molecules onto tyrosine molecules. It's hard to imagine > that so much mischief could be caused by such a simple act! > > Fluorescence In Situ Hybridization (FISH) - a cytogenetic test that > is used to reveal the presence of the " bcr-abl " gene. The abl DNA > shows up as a red dot in the microscope slide and bcr DNA shows as a > green dot (see http://path.upmc.edu/cases/case171/mole.html for a > nice picture). In the nuclei of normal cells, where abl and bcr are > on different chromosomes, these dots appear separately. But in Ph+ > leukemic cells where bcr and abl are fused, the dots appear > together. If you see RedGreen the cell is Ph+, while Red-------Green > (that is, they're far apart) is Ph-, normal. Clever, huh? > > G-CSF = granulocyte colony stimulating factor (brand name Neupogen) = > a naturally occurring hormone that stimulates white blood cell > production > > Graft vs. host disease (GVHD) = a collection of ailments that > complicate stem cell (bone marrow) transplantation. In GVHD, the > donor's immune system (the " graft " ) attacks various of the patient's > (the host's) tissues. > > Hematologic response = normalization of the white blood cell counts > in the blood, though not necessarily in the bone marrow. The response > can be partial (reduction in white cells, but not down to normal > range) or complete (white blood count at or below approximately > 12,000 white cells/microliter) > > Hydrea (hydroxyurea, HU) = a chemotherapy drug which is often used > first in the treatment of CML. Lethal to mature leukemic cells > Hydrea can bring elevated white blood counts (WBCs) back to normal; > however, it does not kill many leukemic stem cells in the bone > marrow, and therefore does not effectively slow the progression of > the disease. > > IFN = interferon > > IM – imatinib mesylate, the brand name for Gleevec (Glivec, outside > the US and Canada) > > LAP = leukocyte alkaline phosphatase: a chemical produced in high > quantities in certain leukemias, but always low in chronic phase CML. > A low serum LAP is thus used to support the diagnosis of CML. > > LD (or LDH) = Lactate dehydrogenase = an enzyme produced by certain > cell and tissue types. It is used to help diagnose CML " blast " > phase, since blasts produce LDH in abnormally high quantities. > > Leukemia = cancer of the white blood cells. Leukemia literally > means " white blood " (leukos = white, and –emia.) > > Leukocyte = white blood cell (leukos = white; cytos = cell in > Greek). The main types of leukocytes are neutrophils, lymphocytes, > monocytes, basophils, and eosinophils. > > LLS = Leukemia & Lymphoma Society > > Lymphocyte = a type of white blood cell generally not involved in > CML. Two main types of lymphocytes are B-Cells and T-Cells. > > Mini-transplant = non-myeloablative stem cell transplant (mini- > transplant) - a type of stem cell transplant in which the patient's > marrow (myelo-) is not destroyed (ablated) prior to the transplant > procedure > > Minimal residual disease = a term used where bcr-abl is still > detectable by PCR, but cytogenetics are negative, or nearly so. > > Molecular response (aka PCRU) = defined as a negative PCR or other > negative molecular test. > > Myelofibrosis = replacement of blood stem cells in the bone marrow > with fibrous tissue. Myelofibrosis occurs as a complication of CML > and of its treatments, especially interferon. > > Myeloproliferative disorder (MPD) = a family of diseases involving > the overproduction of one or another marrow cell types. CML is a > myeloproliferative disorder. > > Neutrophils = the type of myeloid white blood cell which is most > increased in CML. Also referred to as polys (polymorphoneuclear > neutrophils); granulocytes (though this term also includes other > types of white cells, such as basophils and eosinophils); and neuts. > > PEG-IFN = pegyllated interferon: interferon (IFN) that has PEG > (PolyEthylene Glycol) molecules attached to it. PEG gives IFN a > longer half-life in the body, and may reduce the drug's toxicity and > increase its effectiveness. > > Ph = Philadelphia Chromosome. > > Ph+ and Ph- refer to the presence and absence, respectively, of the > Philadelphia chromosome in white blood cells of CML patients. The > proportion of Ph+ to Ph- cells is used to track progress in treating > the disease: anything less than you started with is called a > Cytogenetic Response (CR); 35% or less Ph+ is a Major Cytogenetic > Response (MCR), and 0% Ph+ is a Complete Cytogenetic Response (CCR). > > Philadelphia chromosome (Ph) is a term used to describe the abnormal > appearance certain chromosomes (chromosome #22), in dividing white > blood cells found in 95% of people who have CML. The Philadelphia > chromosome results from a mutation that involves the swapping of > genetic material between chromosome # 9 and chromosome #22 (see bcr- > abl) > > Phillies = abbreviation for philadephia chromosome positive (Ph+) > cells, coined by members of the CML list. > > Polymerase Chain Reaction (PCR) test = a very sensitive test which > can be used to detect the presence of very low levels of specific > genetic material (DNA). It is used to detect, and sometimes to > quantify, bcr-abl in bone marrow cells of patients with CML. The > most sensitive PCR tests can detect as few as on in 100,000,000 > cells. For an explanation of how PCR works, see > http://www.scientific.org/tutorials/articles/riley/riley.html > > Procrit = a brand name for artifically produced erythropoietin, a > hormone that stimulates red blood cell production. > > Stem Cell Transplant (SCT; previously known as bone marrow transplant > or BMT - these terms and abbreviations are used interchangeably, but > SCT is technically more correct) = a procedure in which the patient's > marrow cells are replaced with a donor's marrow cells in hopes of > curing a disease. > > Translocation = where a bit of genetic material from one chromosome > (humans have a total of 46 chromosomes) is swapped with a bit from > another chromosome. In CML, a piece (called " abl " ) from chromosome # > 9 is swapped onto a segment (called " bcr " ) on chromosome #22 to > create the " bcr-abl oncogene " that causes this disease. > > Tyrosine Kinase = an enzymes involved in many kinds of communication > within cells. The bcr-abl gene codes for an abnormal tyrosine kinase > that causes much of the mischief in CML. > > WBC = white blood count – the number of white blood cells in a sample > of blood. > > Zero Club = a term coined by members of the CML list-serve (Zavie > , actually) to refer to patients who have achieved 0% PH+ > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 26, 2009 Report Share Posted March 26, 2009 Thanks Tracey, I figured it out myself, which is rare. Mine is old too, perhaps the same one, I did not look it up. but a lot of the terms can help the newbies, so I thought I'd send it. I sure wish i had it 14 years ago, wish I had this group then too......Bobby a (Bobby) Doyle Brecksville, Ohio, USA DX 05/1995 02/2000 - Gleevec Trial/OHSU 06/2002 - Gleevec/Trisenox Trial/OHSU 06/2003 - Gleevec/Zarnestra Trial/OHSU 04/2004 - Sprycel Trial/MDACC, CCR in 10 months #840 - Zavie's Zero Club 09/2006 - out of CCR 04/29/08 - XL228 Trial/ U.of Michigan 06/02/08 - CCR ( in 4 weeks) 02/13/09 - XL trial ended due to side effects 04/13/09 - New Trial, Ariad / U. of Mich./ Dr. Talpaz From: Tracey <traceyincanada@...> Subject: [ ] CML Glossary Date: Wednesday, March 25, 2009, 9:55 PM There's a CML glossary in the files section of the website but it's really, really old. To get to it, just click on " files " on the left menu of the main page. Then find the glossary and click on it. Tracey Quote Link to comment Share on other sites More sharing options...
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