Local control of thyroid hormone action - role of type 2 deiodinase

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J Endocrinol. 2011 Feb 3. [Epub ahead

of print]

Local

control of thyroid hormone action - role of type 2 deiodinase.

GR, Bassett

D.

G , Molecular Endocrinology

Group, Imperial College London, London, W12 0NN, United Kingdom.

Abstract

The

thyroid gland predominantly secretes the pro-hormone thyroxine (T4) which is

converted to the active hormone 3,5,3'-L-triiodothyronine (T3) in target cells.

Conversion of T4 to T3 is catalyzed by the type 2 iodothyronine deiodinase

enzyme (DIO2) and T3 action in target tissues is determined by DIO2-regulated

local availability of T3 to its nuclear receptors, TRá and TRâ. Studies of Dio2

knockout mice have revealed new and important roles for the enzyme during

development and in adulthood in diverse tissues including the cochlea,

skeleton, brown fat, pituitary and hypothalamus. In this review we discuss the

molecular mechanisms by which DIO2 controls intra-cellular T3 availability and

action.

PMID: 21292729 [PubMed

- as supplied by publisher]