Guest guest Posted April 16, 2011 Report Share Posted April 16, 2011 Hi all, I am currently on 75mcg thyroxine. My highest TSH before starting treatment was 9.4. Once my TSH got within reference range my GP refused to increase my dose anymore. My TSH was 3.84 and my T4 was bottom of range. I did feel better then when first diagnosed but still had some symptoms. My GP's reply tothis was " we treat in blood test results not symptoms " ! Last week I requested further blood tests as for the last two months I have felt like I did originally before starting on any Levo. I phoned for my results and the receptionist said the usual " all normal no further action " . Seems like they are forgetting I requested the tests because I wasnt feeling well they must because my results are fine (or what they call fine)I must be ok. ANyway, she wouldnt give me the figures over the phone so Im going to collect them on Monday and will post them on here. Im assuming they were still within range. ANyway, sorry for the long ramble. My questions are: Im pretty sure that I am lacking in many vitamins and minerals. I know my iron has always been low (15 on last test but will see what latest is). I am going to start taking iron and I have also been reasing what Dr P said about iodine and I am also going to start taking Kelp tablets. Are there any better than others and what sort of dose should I be looking at? Is it ok to take these without having anything tested? I was also looking at changing to unrefined salt. I have read you can buy Maldon sea salt at most supermarkets. Is this the same thing? I'm thinking that I need to get myself in the best possible health to help my thyroid Thank you ne Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 16, 2011 Report Share Posted April 16, 2011 Hi ne - your message needs to be answered more fully than I am going to do here, but I would rather wait to respond until I have seen all the results of your last blood tests. Do remember that your surgery has no right to withhold any of your results and it is ridiculous that the receptionist refused to give your results over the phone. However, we will wait and see what transpires with your results. When you post them, don't forget that we need to reference range for each test done. Did you specifically ask for minerals/vitamins to be tested. Luv - Sheila Im pretty sure that I am lacking in many vitamins and minerals. I know my iron has always been low (15 on last test but will see what latest is). I am going to start taking iron and I have also been reasing what Dr P said about iodine and I am also going to start taking Kelp tablets. Are there any better than others and what sort of dose should I be looking at? Is it ok to take these without having anything tested? I was also looking at changing to unrefined salt. I have read you can buy Maldon sea salt at most supermarkets. Is this the same thing? Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 16, 2011 Report Share Posted April 16, 2011 Hi ne: Although Dr Barry's talk on Iodine was great, it is outdated. We no longer recommend KELP. The reason being is that our seas are contaminated and we don't know what may be in kelp anymore. It could do more harm than good. There is also not enough iodine in kelp to help you unless you are taking barrel fulls everyday. Iodine comes in IODORAL tablets or Lugol's drops. Either one will enhance your system. The other thing left out of his speech is that there is a iodine protocol which must be followed with the intake of iodine. It's not an optional thing. You must take certain supplements with the iodine. You can join the iodine group for more info in the new member doc or you can email me and I can give you the protocol: iodine/ It is important that everyone gets the 94 trace minerals in their body on a daily basis. Celtic Sea Salt, Himalayan Rock salt, Trace Mineral drops or Spirulina will help with that. Celtic Sea salt has been examined for contamination and heavy metals, so it is your best bet for unrefined salt. I like people to take Spirulina because it has all sorts of good nutrients in it including a bit of iron. Everyone I know has taken it for years and it is truly a life saver. I like this brand the best, they've been making it for 25 years: http://www.iherb.com/Nutrex-Pure-Hawaiian-Spirulina-Pacifica-500-mg-400-Tablets/\ 12641?at=0 As far as supplementing with iron, we really like to see blood labs for that....you never want to take too much iron in case you have hemochromatosis. I would assume everyone would know if they had HEM because it would be written in your medical file in big RED letters !! This is something DRs don't want to miss. When you know if you need to supplement to bring your iron levels up, I recommend *bisglycinate* iron which is a form of amino acid chelate. This absorbs easier in the system and has many positive attributes which other forms of iron do not. http://www.iherb.com/Bluebonnet-Nutrition-Chelated-Iron-90-Vcaps/11571?at=0 Cheers, JOT > Im pretty sure that I am lacking in many vitamins and minerals. I know my iron has always been low (15 on last test but will see what latest is). I am going to start taking iron and I have also been reasing what Dr P said about iodine and I am also going to start taking Kelp tablets. Are there any better than others and what sort of dose should I be looking at? Is it ok to take these without having anything tested? I was also looking at changing to unrefined salt. I have read you can buy Maldon sea salt at most supermarkets. Is this the same thing? > > I'm thinking that I need to get myself in the best possible health to help my thyroid > Thank you > ne > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 16, 2011 Report Share Posted April 16, 2011 Hi JOT - can you pass on the iodine protocol to all the members here so we all know (we can't all join the Iodine group - I have too much to do already) and I can then put it into the IODINE folder in our FILES section for all new members to check out. And you are correct, we don't recommend Kelp - go straight for the Lugol's drops or Iodoral/ Many thanks Luv - Sheila Although Dr Barry's talk on Iodine was great, it is outdated. We no longer recommend KELP. The reason being is that our seas are contaminated and we don't know what may be in kelp anymore. It could do more harm than good. There is also not enough iodine in kelp to help you unless you are taking barrel fulls everyday. Iodine comes in IODORAL tablets or Lugol's drops. Either one will enhance your system. The other thing left out of his speech is that there is a iodine protocol which must be followed with the intake of iodine. It's not an optional thing. You must take certain supplements with the iodine. You can join the iodine group for more info in the new member doc or you can email me and I can give you the protocol: .._,___ Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 16, 2011 Report Share Posted April 16, 2011 Here you go, Sheila: Supporting Nutrients for taking Iodine. These are required to support the body while supplementing with iodine: a. Vit C – 2,000 – 5,000 mgs / day – supports the symporters and assists as an antioxidant to detoxing. b. Selenium – 200 – 400 mcg / day – needed for detoxification and thyroid hormone creation. c. Unrefined salt (Celtic) – ½ tsp / day – supports adrenals, binds to bromide and assists in removal, supports symporters (sodium iodine symporters or NIS) d. Magnesium – 400 mgs / day – critical for over 300 enzyme reactions in the body. e. Optional – ATP CoFactors -1 tablet 2x / day – when individuals continue to feel fatigued or have autoimmune thyroid disease this product can assist in increasing ATP (energy) within the cells. Riboflavin and no-flush niacin. Cheers, JOT > Hi JOT - can you pass on the iodine protocol to all the members here Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 16, 2011 Report Share Posted April 16, 2011 Why cant you give us all the protocol Sheila. I would like this too. Lilian You must take certain supplements with the iodine. You can join the iodine group for more info in the new member doc or you can email me and I can give you the protocol: Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 17, 2011 Report Share Posted April 17, 2011 I think you were meaning to address this message to JOT Lilian. I did write and ask JOT to let us have it and she passed it on so I have now put this information together and put it into the Iodine Folder in the FILES section under the heading 'Kelp versus Iodine'. You should have had notification from that this file has been uploaded earlier this morning. Luv - Sheila From: thyroid treatment [mailto:thyroid treatment ] On Behalf Of recent:lilian15@... Sent: 16 April 2011 22:03 thyroid treatment Subject: Re: Re: advice re. kelp and unrefined salt Why cant you give us all the protocol Sheila. I would like this too. Lilian You must take certain supplements with the iodine. You can join the iodine group for more info in the new member doc or you can email me and I can give you the protocol: Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 17, 2011 Report Share Posted April 17, 2011 Yes, I did get notification after sending message regarding it and I have now read it. That is why I noticed the small error, that it says the protocol is optional whereas it should have said is NOT optional. I do not know who can correct this, but I think it should be just in case someone reads it as being optional. Although further on it says it should be followed. So at the most someone could be confused as to whether it is, or is not, optional to follow the protocol. Lilian Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 19, 2011 Report Share Posted April 19, 2011 MODERATED TO REMOVE MOST OF PREVIOUS MESSAGE. PLEASE DELETE THIS LEAVING JUST A SMALL PORTION BEFORE CLICKING 'SEND'. LUV - SHEILA _________________________________________________________ Hi, Sheila you asked me to post my results when I collected them: TSH 3.7 (range 0.1 - 4) T4 12 (range 8-20) T3 not tested. I had asked for my iron to be tested. I can't see ferritin on results. All I can see is HB which is 12.6 (range 11.5-16.5). Im getting a bit fed up now with them refusing to increase my dose even though I keep edging to top of range for TSH although I do feel that I can probably help myself by improving my vitamins and minerals first as I am sure these are lacking. Someone mentioned Spirulina which I am going to try as I believe it also contains iron. Thank you. susanne I phoned for my results and the receptionist said the usual " all normal no further action " . Seems like they are forgetting I requested the tests because I wasnt feeling well they must because my results are fine (or what they call fine)I must be ok. ANyway, she wouldnt give me the figures over the phone so Im going to collect them on Monday and will post them on here. > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 20, 2011 Report Share Posted April 20, 2011 > > MODERATED TO REMOVE MOST OF PREVIOUS MESSAGE. PLEASE DELETE THIS LEAVING JUST A SMALL PORTION BEFORE CLICKING 'SEND'. LUV - SHEILA > _________________________________________________________ > Just bumping this hope that is ok. Sx Hi, > > Sheila you asked me to post my results when I collected them: > > TSH 3.7 (range 0.1 - 4) > T4 12 (range 8-20) > T3 not tested. > > I had asked for my iron to be tested. I can't see ferritin on results. All I can see is HB which is 12.6 (range 11.5-16.5). > > Im getting a bit fed up now with them refusing to increase my dose even though I keep edging to top of range for TSH although I do feel that I can probably help myself by improving my vitamins and minerals first as I am sure these are lacking. Someone mentioned Spirulina which I am going to try as I believe it also contains iron. > > Thank you. > susanne > > I phoned for my results and the receptionist said the usual " all normal no further action " . Seems like they are forgetting I requested the tests because I wasnt feeling well they must because my results are fine (or what they call fine)I must be ok. ANyway, she wouldnt give me the figures over the phone so Im going to collect them on Monday and will post them on here. > > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 20, 2011 Report Share Posted April 20, 2011 Just bumping this hope that is ok. Sx > Sheila you asked me to post my results when I collected them: > > TSH 3.7 (range 0.1 - 4) > T4 12 (range 8-20) > T3 not tested. TSH is too high, it should be around 1.0 for you to feel normal. This high a TSH shows your pituitary is having to work hard to tell your thyroid gland to secrete the level of thyroid hormone your body requires. For anybody NOT on any thyroid hormone replacement, the free T4 should be just above the middle of the reference range which means that your fT4 should be around 15/16 - so your free T4 is too low. > I had asked for my iron to be tested. I can't see ferritin on results. All I can see is HB which is 12.6 (range 11.5-16.5). Ask your GP again to test your levels of ferritin, vitamin B12m, vitamin D3, magnesium, folate, copper and zinc because if any of these are low in the range, your thyroid hormone cannot be properly utilised at the cellular level. This is important, if your GP tells you that there is no connection between low levels and thyroid, then copy out the attached document and send it to him showing references to the scientific evidence to show exactly what the connection is. Your HB is low. Ask what other tests were done at the time and ask for the results with the reference range for each test as your GP cannot withhold these from you. > Im getting a bit fed up now with them refusing to increase my dose even though I keep edging to top of range for TSH although I do feel that I can probably help myself by improving my vitamins and minerals first as I am sure these are lacking. Someone mentioned Spirulina which I am going to try as I believe it also contains iron. Ask your GP WHY they are bothering to test your TSH if they are not paying any attention to the result. By refusing to increase your levothyroxine this is proof that they are not understanding what these thyroid function tests actually mean. They appear incapable in interpreting them properly. Ask in a letter for a referral to an endocrinologist because it is a fact this doctor doesn't understand the function of the thyroid system. Luv - Sheila .._,___ 1 of 1 File(s) MINERALS AND VIT. TESTING.doc Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 21, 2011 Report Share Posted April 21, 2011 Hi, Those results, while still being inside the range are not ideal. Most healthy folk have a TSH of around 1.0( this is one case where lower is better) and FT4 is much closer to the bottom of that range than the top. As usual FT3 was not done, so we can't tell if you are converting the available T4 into sufficient T3- which is the active hormone. I would go back and say that there is plenty of headroom before you go out of range and ask again for a dose increase, if the doc still says no, then ask for a referral to an endo of your choice. You can feel very different at opposite ends of the range. you may like to write this request as doc often take letters more seriously- the can come back and bite if the doc is subsequently proved wrong- keep copies of all correspondance. > thyroid treatment > From: j.leighton498@...> Date: Wed, 20 Apr 2011 08:26:10 +0000> Subject: Re: advice re. kelp and unrefined salt> > > > > >> > MODERATED TO REMOVE MOST OF PREVIOUS MESSAGE. PLEASE DELETE THIS LEAVING JUST A SMALL PORTION BEFORE CLICKING 'SEND'. LUV - SHEILA> > _________________________________________________________> > > Just bumping this hope that is ok. Sx > Hi,> > > > Sheila you asked me to post my results when I collected them:> > > > TSH 3.7 (range 0.1 - 4)> > T4 12 (range 8-20)> > T3 not tested.> > > > I had asked for my iron to be tested. I can't see ferritin on results. All I can see is HB which is 12.6 (range 11.5-16.5).> > > > Im getting a bit fed up now with them refusing to increase my dose even though I keep edging to top of range for TSH although I do feel that I can probably help myself by improving my vitamins and minerals first as I am sure these are lacking. Someone mentioned Spirulina which I am going to try as I believe it also contains iron.> > > > Thank you.> > susanne> > > > >> > >> >> > > > > ------------------------------------> > TPA is not medically qualified. Consult with a qualified medical practitioner before changing medication.> > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 21, 2011 Report Share Posted April 21, 2011 Hi Would someone mind helping me compose a letter to the GP reqesting that my dose is increased and if not, to be referred to an endo of my choice? Im ok at writing letters but I want to make sure I have any necessary references in there. I think I would be best putting it in writing for the reason mentioned but also because Im not very assertive when I see the Gp face to face. Thank you ne > > > Hi> I would go back and say that there is plenty of headroom before you go out of range and ask again for a dose increase, if the doc still says no, then ask for a referral to an endo of your choice. You can feel very different at opposite ends of the range. you may like to write this request as doc often take letters more seriously- the can come back and bite if the doc is subsequently proved wrong- keep copies of all correspondance. > > > > > >> > > >> > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 21, 2011 Report Share Posted April 21, 2011 Dear Dr ****** I feel that I can no longer carry on with the thyroid medication that is being prescribed to me at the moment in the dose that it is. It is not helping eliminate any of my symptoms or signs, and I feel my health is gradually getting worse. At the moment, I am suffering with (here list all of your symptoms and signs - check these out in our web site www.tpa-uk.org.uk under 'Hypothyroidism. It matters not how long the list is, write down every single one. Also, list the 'signs' you are showing - your GP should be able to see these if you were given a thorough clinical examination). My basal temperature for the last 4 mornings taken before I got out of bed or had anything to drink was (here list your temperatures each morning. Normal is 98.6 degrees F, or 37 degrees C) I do feel there is a possibility that I am suffering because I need an increase in my levothyroxine dose and would like a trial of another 25mcgs daily, as I understand the average daily dose is between 125mcgs and 150mcgs daily. I am concerned also that thyroxine is a mainly inactive thyroid hormone that has to convert to the active thyroid hormone triiodothyronine (T3) and that it is T3 your body needs, not T4. I am also aware that there is a large minority of sufferers unable to convert T4 to T3 for many and varied reasons and wonder whether this might apply to me. I have learned that there are two types of hypothyroidism: 1.Type 1 hypothyroidism (primary, secondary, and tertiary hypothyroidism) which are properly associated with insufficient secretion by the thyroid gland, thereby reducing the T4 available for conversion, to T3 to energize the body. The most common cause originating within the thyroid gland is disease process. It would still be considered primary, secondary and tertiary hypothyroidism (Type 1), even if it is due to a damaged gland, e.g. when damage is caused in an accident or damaged due to excessive exposure to radioactivity. Type 1 Hypothyroidism may be corrected by using levothyroxine (T4-only) replacement, but does this type of hypothyroidism apply to me, and if so, an increase in my thyroxine dose may help me. Blood tests results will show whether the thyroid gland is secreting sufficient thyroid hormone. 2. Type 2 hypothyroidism is defined as deficiencies in the peripheral conversion of T4 to T3, the subsequent reception of T3, and the use of T3 by the body's cells. This apparently ignored hypothyroidism reduces the amount of the active thyroid hormone T3 in the body, producing the same sort of symptoms that Type 1 hypothyroidism does. Environmental toxins may also cause or exacerbate the problem. The pervasiveness of Type 2 hypothyroidism has yet to be recognised by mainstream medicine but already is in epidemic proportions. Type 2 hypothyroidism can be corrected by T3 hormone replacement therapy - and not by thyroxine-only therapy - so does this type of hypothyroidism apply to me, and if so, a trial of the thyroid hormone T3 may be what I need, and not T4? Serum Thyroid Function Tests do NOT show whether a person is suffering with Type 2 hypothyroidism. If you feel you are unable to help me, would you please refer me to an endocrinologist so that I can discuss my present problems with her/him please. Meanwhile, as low levels of certain minerals/vitamins are associated with either 'type' of hypothyroidism and stop the thyroid hormone being fully utilised at the cellular level, please would you arrange for my blood to be tested for ferritin, vitamin B12, vitamin D3, magnesium, folate, copper and zinc. The references below point to research that shows the association between these and hypothyroidism: Low iron/ferritin: Iron deficiency is shown to significantly reduce T4 to T3 conversion, increase reverse T3 levels, and block the thermogenic (metabolism boosting) properties of thyroid hormone (1-4). Thus, iron deficiency, as indicated by an iron saturation below 25 or a ferritin below 70, will result in diminished intracellular T3 levels. Additionally, T4 should not be considered adequate thyroid replacement if iron deficiency is present (1-4)). 1. Dillman E, Gale C, Green W, et al. Hypothermia in iron deficiency due to altered triiodithyroidine metabolism. Regulatory, Integrative and Comparative Physiology 1980;239(5):377-R381. 2. SM, PE, Lukaski HC. In vitro hepatic thyroid hormone deiodination in iron-deficient rats: effect of dietary fat. Life Sci 1993;53(8):603-9. 3. Zimmermann MB, Köhrle J. The Impact of Iron and Selenium Deficiencies on Iodine and Thyroid Metabolism: Biochemistry and Relevance to Public Health. Thyroid 2002;12(10): 867-78. 4. Beard J, tobin B, Green W. Evidence for Thyroid Hormone Deficiency in Iron-Deficient Anemic Rats. J. Nutr. 1989;119:772-778. Low vitamin B12: http://www.ncbi.nlm.nih.gov/pubmed/18655403 Low vitamin D3: http://www.eje-online.org/cgi/content/abstract/113/3/329 and http://www.goodhormonehealth.com/VitaminD.pdf Low magnesium: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC292768/pdf/jcinvest00264-0105.pdf Low folate: http://www.clinchem.org/cgi/content/full/47/9/1738 and http://www.liebertonline.com/doi/abs/10.1089/thy.1999.9.1163 Low copper/zinc:http://www.istanbul.edu.tr/ffdbiyo/current4/07%20Iham%20AM%C4%B0R.pdf and http://articles.webraydian.com/article1648-Role_of_Zinc_and_Copper_in_Effective_Thyroid_Function.html I await hearing from you in due course. Yours sincerely ne ****** Would someone mind helping me compose a letter to the GP requesting that my dose is increased and if not, to be referred to an endo of my choice? Im ok at writing letters but I want to make sure I have any necessary references in there. I think I would be best putting it in writing for the reason mentioned but also because Im not very assertive when I see the Gp face to face. Thank you ne Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 22, 2011 Report Share Posted April 22, 2011 Thank you Sheila that is perfect. Its being posted today. I have also included the research on it being safe for patients taking thyroxie to have a lower TSH than currently recommended because everytime I have asked for an increase in the past I have been told its dangerous for my heart and bones. I now need to try and find a good endo in Manchester area in case they refer me. Thanks again ne > > Dear Dr ****** > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 22, 2011 Report Share Posted April 22, 2011 Hi ne, If they tell you again that they can't give you an increased dose because it is dangerous for your heart and bones, then tell them that some common and often undiagnosed symptoms and dangerous consequences of low thyroid can include: serious mental problems, seizures, heart disease, diabetes including misdiagnosis and complications, constipation resulting in colon cancer, all female problems (due to high amounts of dangerous forms of oestrogen), including: tumours, fibroids, ovarian cysts, PMS, endometriosis, breast cancer, miscarriage, heavy periods and cramps, bladder problems leading to infections, anaemia, elevated CPK, elevated creatinine, elevated transaminases, hypercapnia, hyperlipidaemia, hypoglycaemia, hyponatraemia, hypoxia, leukopaenia respiratory acidosis and others.... Also, ask them to cite references to the scientific evidence that show taking the thyroid hormone replacement your body requires would cause osteoporis and ask them to check out the following: Osteoporosis: the improvement with thyroid treatment · Svanberg E, Healey J, Mascarenhas D. Anabolic effects of rhIGF-I/IGFBP-3 in vivo are influenced by thyroid status. Eur J Clin Invest. 2001 Apr;31(4):329-36. Bone loss is mainly transitory only during the first year with no increased fracture incidence· Tremollieres F, Pouilles JM, Louvet JP, Ribot C. Transitory bone loss during substitution treatment for hypothyroidism.· Results of a two year prospective study. Rev Rhum Mal Osteoartic. 1991 Dec;58(12):869-75· Ribot C, Tremollieres F, Pouilles JM, Louvet JP. Bone mineral density and thyroid hormone therapy. Clin Endocrinol (Oxf). 1990 Aug;33(2):143-53 Oestrogen therapy neutralizes, prevents bone loss induced by corrective thyroid therapy · Schneider DL, Barrett-Connor EL, Morton DJ. Thyroid hormone use and bone mineral density in elderly women. JAMA 1994;271:1245-9 Studies where thyroid therapy does not cause or increase loss of bone density · Greenspan SL, Greenspan FS, Resnick NM, Block JE, Friedlander AL, Genant HK. Skeletal integrity in premenopausal and postmenopausal women receiving long-term L-thyroxine therapy Am J Med. 1991;91:5-14 · lyn JA, Betteridge J, Daykin J, Holder R, Oates GD, Parle JV, Lilley J, Heath DA, Sheppard MC. Long-term thyroxine treatment and bone mineral density. Lancet. 1992 Jul 4;340(8810):9-1 · Eulry F, Bauduceau B, Lechevalier D, Magnin J, Crozes P, Flageat J, Gautier D. Bone density in differentiated cancer of the thyroid gland treated by hormone-suppressive therapy. Study based on 51 cases. Rev Rhum Mal Osteoartic. 1992 Apr;59(4):247-52 · Grant DJ, McMurdo ME, Mole PA, Paterson CR, Davies RR. Suppressed TSH levels secondary to thyroxine replacement therapy are not associated with osteoporosis. Clin Endocrinol (Oxf). 1993 Nov;39(5):529-33. Studies where thyroid therapy improves bone formation · Svanberg E, Healey J, Mascarenhas D. Anabolic effects of rhIGF-I/IGFBP-3 in vivo are influenced by thyroid status. Eur J Clin Invest. 2001 Apr;31(4):329-36 As far as " causing heart problems " is concerned, blind them with science and ask them whether or not they have read any of the following papers: A low serum T3 or T4 (hypothyroidism) is found in cardiac failure: 1. Khaleeli AA, Memon N. Factors affecting resolution of pericardial effusions in primary hypothyroidism: a clinical, biochemical and echocardiographic study. Postgrad Med J. 1982 Aug;58(682):473-62. Reza MJ, Abbasi AS. Congestive cardiomyopathy in hypothyroidism. West J Med. 1975 Sep;123(3):228-303. Rays J, Wajngarten M, Gebara OC, Nussbacher A, Telles RM, Pierri H, no G, Serro-Azul JB. Long-term prognostic value of triiodothyronine concentration in elderly patients with heart failure. Am J Geriatr Cardiol. 2003 Sep-Oct;12(5):293-7 (“Lower serum T3 in cardiac failure: the odds ratio for events was 9.8 (95% confidence interval,2.2-43, p=0.004) for patients in the lowest tertile of triiodothyronine, that is, lower than 80 ng/dL, compared with patients with levels above 80 ng/dL”)4. Pingitore A, Landi P, Taddei MC, Ripoli A, L'Abbate A, Iervasi G. Triiodothyronine levels for risk stratification of patients with chronic heart failure. Am J Med. 2005 Feb;118(2):132-6 5. Klein I, Ojama K. In: Werner & Ingbar’s The Thyroid, ed. Braverman LE & Utiger RD, Lippincott-Raven Publishers, Philadelphia, 1996, 62: 799-804 A low serum free T3 index/reverse T3 ratio in chronic heart failure patients is a highly significant predictor of poor outcome 6. Cerillo AG, Bevilacqua S, Storti S, ni M, Kallushi E, Ripoli A, Clerico A, Glauber M. Free triiodothyronine: a novel predictor of postoperative atrial fibrillation. Eur J Cardiothorac Surg. 2003 7. Hamilton MA, son LW, Luu M, Walden JA. Altered thyroid hormone metabolism in advanced heart failure. J Am Coll Cardiol. 1990 Jul;16(1):91-5 8. Kozdag G, Ural D, Vural A, Agacdiken A, Kahraman G, Sahin T, Ural E, Komsuoglu B. Relation between free triiodothyronine/free thyroxine ratio, echocardiographic parameters and mortality in dilated cardiomyopathy. Eur J Heart Fail. 2005 Jan;7(1):113-8 A low serum T3 or T4 in heart patients is associated with an increased risk of cardiac arrest/death 9. Wortsman J, Premachandra BN, Chopra IJ, JE. Hypothyroxinemia in cardiac arrest. Arch Intern Med. 1987 Feb;147(2):245-8 10. Iervasi G, Pingitore A, Landi P, Raciti M, Ripoli A, Scarlattini M, L'Abbate A, Donato L. Low-T3 syndrome: a strong prognostic predictor of death in patients with heart disease. Circulation. 2003 Feb 11;107(5):708-13 Cardiovascular disease and mortality is increased in hypothyroidism (+ 70 % for both) 11. Dorr M, Volzke H. Cardiovascular morbidity and mortality in thyroid dysfunction. Minerva Endocrinol. 2005 Dec;30(4):199-216 Thyroid therapy of cardiac patientsCorrective thyroid therapy is safe in hypothyroid patients with common benign cardiac arrhythmias at the condition that thyroid treatment is started at low doses and then gradually and prudently increased to the adequate dose. The treatment does not trigger an increase in arrhythmia frequency except in rare patients with baseline atrial premature beats. It is, however, associated with an increase in basal, average and maximal heart rates.12. Polikar R, Feld GK, Dittrich HC, J, Nicod P. Effect of thyroid replacement therapy on the frequency of benign atrial and ventricular arrhythmias. J Am Coll Cardiol. 1989 Oct;14(4):999-1002Thyroid therapy corrects the bradycardia of hypothyroidism13. Yamauchi K, Takasu N, Ichikawa K, Yamada T, Aizawa T. Effects of long-term treatment with thyroxine on pituitary TSH secretion and heart action in patients with hypothyroidism. Acta Endocrinol (Copenh). 1984 Oct;107(2):218-24 (“T4 doses should be adjusted to maintain normal ET/PEP (systolic time intervals) rather than normal serum TSH levels”)Thyroid therapy corrects the ventricular arrhythmia14. Vanin LN, Smetnev AS, Sokolov SF, Kotova GA, Masenko VP. Thyroid function in patients with ventricular arrhythmia. Kardiologiia. 1989 Feb;29(2):64-7 (“Thyroid therapy for hypothyroidism led to the disappearance of paroxysms of ventricular tachycardia and reduced the total number and grades of ventricular extra-systoles in patients with ventricular arrhythmias; moreover, sensitivity to antiarrhythmic agents developed to replace an earlier resistance”) Coronary heart disease in humans: the improvement with thyroid treatment 15. BO. Prophylaxis of ischaemic heart-disease by thyroid therapy. Lancet. 1959 Aug 22;2:149-52 16. Holland FW 2nd, Brown PS Jr, RE. Acute severe postischemic myocardial depression reversed by triiodothyronine. Ann Thorac Surg. 1992 Aug;54(2):301-5 17. Israel M. An effective therapeutic approach to the control of atherosclerosis illustrating harmlessness of prolonged use of thyroid hormone in coronary disease. Am J Dig Dis. 1955 June;161-8 18. Yokoyama Y, Novitzky D, Deal MT, Snow TR. Facilitated recovery of cardiac performance by triiodothyronine following a transient ischemic insult. Cardiology. 1992;81(1):34-45 Adequate thyroxine replacement in hypothyroidism prevents coronary artery disease progression 19. Perk M, O’Neill BJ; The effect of thyroid therapy on angiographic artery disease progression . Can J Card. 1997;13(3):273-6 Desiccated thyroid therapy improves cardiac failure refractory to digitalis in humans 20. Zondek H. Myxedema Heart. Munch Med Wochenschr. 1918, 65: 1180-3 21. Khaleeli AA, Memon N. Factors affecting resolution of pericardial effusions in primary hypothyroidism: a clinical, biochemical and echocardiographic study. Postgrad Med J. 1982 Aug;58(682):473-6 T3-therapy improves the outcome of open heart sugery, especially heart transplants 22. Novitzky D, Fontanet H, Snyder M, Coblio N, D, Parsonnet V. Impact of triiodothyronine on the survival of high-risk patients undergoing open heart surgery. Cardiology. 1996 Nov-Dec;87(6):509-15. 23. Novitzky D, DK, Chaffin JS, Greer AE, DeBault LE, Zuhdi N. Improved cardiac allograft function following triiodothyronine therapy to both donor and recipient. Transplantation. 1990 Feb;49(2):311-6 Thyroid hormone therapy greatly reduces the lesions of experimental myocardial infarct in rats 24. Holland FW, Brown PS, RE. Acute severe postischemic myocardial depression reversed by triiodothyronine. Ann Thorac Surg 1992 54: 301-305 Thyroid therapy reduces coronary artery disease and cardiac fibrosis in mice25. Yao J, Eghbali M. Decreased collagen mRNA and regression of cardiac fibrosis in the ventricular myocardium of the tight skin mouse following thyroid hormone treatment. Cardiovasc Res. 1992 Jun;26(6):603-7Thyroid therapy reduced the lesions of experimental cardiac arrest in dogs26. Facktor MA, Mayor GH, Nachreiner RF, D'Alecy LG. Thyroid hormone loss and replacement during resuscitation from cardiac arrest in dogs. Resuscitation. 1993 Oct;26(2):141-62 Thyroid therapy reduced the complications of hemorrhagic shock in dogs 27. Shigematsu H, Shatney CH. The effect of triiodothyronine (T3) and reverse triiodothyronine (rT3) on canine hemorrhagic shock. Nippon Geka Gakkai Zasshi. 1988 Oct;89(10):1587-93. Thank you Sheila that is perfect. Its being posted today. I have also included the research on it being safe for patients taking thyroxie to have a lower TSH than currently recommended because everytime I have asked for an increase in the past I have been told its dangerous for my heart and bones. I now need to try and find a good endo in Manchester area in case they refer me. Thanks again ne > > Dear Dr ****** > > > > Quote Link to comment Share on other sites More sharing options...
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