Extrathyroidal thyroid hormone synthesis?

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J Endocrinol. 2011 May 3. [Epub ahead

of print]

Extrathyroidal thyroid

hormone synthesis?

Ludgate

ME.

Source

M Ludgate, CEDS, Cardiff University, Cardiff,

CF14 4XN, United Kingdom.

Abstract

A recent paper published in the Journal of

Endocrinology, has revisited the hypothesis that thyroid hormones may be

generated by tissues outside the thyroid gland in higher organisms, including

mammals. This commentary appraises the strengths and weaknesses of the study,

the alternative explanations for the findings and possible future measures to

investigate further. The concept of extrathyroidal thyroxine (T4) and

triiodothyronine (T3) synthesis has been proposed previously; having assumed

that Nagao et al and earlier authors are correct, the plausibility and possible

mechanisms underlying the hypothesis are discussed.

PMID:

21540255

[PubMed - as supplied by

publisher]