Guest guest Posted January 4, 2007 Report Share Posted January 4, 2007 Finished: I am confused about your FYI on a BMT. Basically the BMT is a stem cell transplant. They remove the stem cells from the donor and transfuse them into the reciepent. Very undramatic. There is still GVHD even with a full matched donor. I have crossed into the dark side. I have decided to go with the BMT or stem cell transplant, whichever you prefer to call it. Gleevec is not my gold, as I have told you before. I am grateful for all the people that are succeeding with it. I wish it had held longer for me. I have a matched donor and I am going for this. I am worn down by side effects and working full time. If I don't cure this, the drugs they are experimenting on me with are going to kill me. I am like you I, I have multiple health issues also. I also work full time and dealing with this is becoming crazy with endless hurdles. Before I have major organ damage from being an experiment, I am going for the cure. The only cure known for this disease. I wish you well, and hope your " gold " holds you forever. I would like to be there to see my daughter Haley graduate from high school in two years. My other daughter Morgen will be graduating from college around the same time. I plan to be there to celebrate with them both. The way treatment is going for me, I think I am making a wise choice, Good luck all. T Stone IAintFinishedYet <kttweety@...> wrote: Hey Group: FYI~~my 2 cents After being given 2-5 months morbid mortality in November 2003. . . After going through HELL and being labeled " Queen of the Side Effects " . . . After being told that CML is no longer a terminal disease, now its a Chronic Disease with a newly diagnosed person having a 25 year median mortality. . . After being told that Gleevec is a maintenance medication. . . After being told that AMS & BMS are not either/or medications for Gleevec; they are for survivors who have became intolerant or failed Gleevec therapy. . . After knowing survivors die from a BMT; who were otherwise surviving on Gleevec because GVHD is a KILLER. . .or living the Gleevec life again. After being told that CML is a Chronic Disease, much like Diabetes, for which there's no CURE. . . After being told that CML is a Chronic Disease, much like Diabetes, for which there's no CURE. . . After reaching my maximum response, I know that my demise will be from one of my other 20 fatal/terminal/chronic diseases. . .all of which I call Chronic Illnesses. . . I named CML~~ my 'bug'. . . I named Gleevec~~ my 'gold' . . . I named Plavix/Heart Disease~~my 'platinum' I named Pain Medications/Orthopedic Diseases~~my 'silver' After knowing in my heart that the CURE isn't the BMT. . .it will come from SCT~~Stem Cell Transplant. I heard that our President is vetoing the bill again. We need to appeal to our Senators so that they over-ride him. That way the research and development into SCT can forge ahead. In the meantime; I say Thanx God, Dr. Drucker~~Father of Gleevec, Dr. Talpaz~~Father of CML (doing SC research at UMCCC, the only facility in the US), Zavie, , , Anjana, , Skip, etc., for being there for me when I had a question or concern; and I take my 'gold' because. . . " I AM A SURVIVOR. . .I AIN'T FINISHED YET " ! ! ! HAPPY NEW YEAR. . .I have ALL in my prayers. " K " " I AIN'T FINISHED YET " !!! Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 4, 2007 Report Share Posted January 4, 2007 I am adding my $.02 to Therese's post and K's post. From medterms.com > Definition of Stem cell > > > > Stem cell: One of the human body's master cells, with the ability > to grow into any one of the body's more than 200 cell types. > > All stem cells are unspecialized (undifferentiated) cells that are > characteristically of the same family type (lineage). They retain > the ability to divide throughout life and give rise to cells that > can become highly specialized and take the place of cells that die > or are lost. > > Stem cells contribute to the body's ability to renew and repair its > tissues. Unlike mature cells, which are permanently committed to > their fate, stem cells can both renew themselves as well as create > new cells of whatever tissue they belong to (and other tissues). > > Bone marrow stem cells, for example, are the most primitive cells > in the marrow. From them all the various types of blood cells are > descended. Bone marrow stem-cell transfusions (or transplants) were > originally given to replace various types of blood cells. So bone marrow cells are stem cells. Bone marrow is made up of " adult " stem cells. I am thinking that you might be referring to embryonic stem cells, which are not " adult " stem cells and MAY be more flexible in what they do than bone marrow cells. This may be the future of curing many diseases/conditions but we will never find out if funding isn't put into this research (my opinion). My thought is that there will still be GVH & rejection concerns no matter what kind of cells are used, but embryonic/immature stem cells may produce less " rejection " . The process right now is that the " old " stem cells are killed off using chemo and (perhaps) radiation. You still have to get rid of the leukemia. I don't know that this process would change if you use embryonic/immature cells. Good luck to both of you no matter what road you choose to travel. Therese, feel free to email me privately or visit this site: http://www.caringbridge.org/wi/tomneddo My son went through an MUD BMT 5/05/05 in Minneapolis. Barb Neddo Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 4, 2007 Report Share Posted January 4, 2007 Barb: Thank you for your interptation. I appreicate it. I also will have a MUD. How is your son doing after transplant? Do you feel that it was worth the risk taken? Take care and best wishes. Therese Barb Neddo <barb.neddo@...> wrote: I am adding my $.02 to Therese's post and K's post. From medterms.com > Definition of Stem cell > > > > Stem cell: One of the human body's master cells, with the ability > to grow into any one of the body's more than 200 cell types. > > All stem cells are unspecialized (undifferentiated) cells that are > characteristically of the same family type (lineage). They retain > the ability to divide throughout life and give rise to cells that > can become highly specialized and take the place of cells that die > or are lost. > > Stem cells contribute to the body's ability to renew and repair its > tissues. Unlike mature cells, which are permanently committed to > their fate, stem cells can both renew themselves as well as create > new cells of whatever tissue they belong to (and other tissues). > > Bone marrow stem cells, for example, are the most primitive cells > in the marrow. From them all the various types of blood cells are > descended. Bone marrow stem-cell transfusions (or transplants) were > originally given to replace various types of blood cells. So bone marrow cells are stem cells. Bone marrow is made up of " adult " stem cells. I am thinking that you might be referring to embryonic stem cells, which are not " adult " stem cells and MAY be more flexible in what they do than bone marrow cells. This may be the future of curing many diseases/conditions but we will never find out if funding isn't put into this research (my opinion). My thought is that there will still be GVH & rejection concerns no matter what kind of cells are used, but embryonic/immature stem cells may produce less " rejection " . The process right now is that the " old " stem cells are killed off using chemo and (perhaps) radiation. You still have to get rid of the leukemia. I don't know that this process would change if you use embryonic/immature cells. Good luck to both of you no matter what road you choose to travel. Therese, feel free to email me privately or visit this site: http://www.caringbridge.org/wi/tomneddo My son went through an MUD BMT 5/05/05 in Minneapolis. Barb Neddo Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 4, 2007 Report Share Posted January 4, 2007 Hi Therese, Please reconsider. If your goal in life is to see your daughters graduate in two years from now then I would suggest that you research the morbidity and mortality rates of a BMT. Compare the BMT statistics to any of the CML medications and the resulting answer is a no brainer. Also, be prepared to be off work for a lengthy period of time. Zavie Zavie (age 68) 67 Shoreham Avenue Ottawa, Canada, dxd AUG/99 INF OCT/99 to FEB/00, CHF No meds FEB/00 to JAN/01 Gleevec since MAR/27/01 (400 mg) CCR SEP/01. #102 in Zero Club PCRU 5/02 at RVH 2.8 log reduction Sep/05 3.0 log reduction Jan/06 e-mail: zmiller@... Tel: 613-726-1117 Fax: 309-296-0807 Cell: 613-202-0204 ID: zaviem Re: [ ] CML is a disease Finished: I am confused about your FYI on a BMT. Basically the BMT is a stem cell transplant. They remove the stem cells from the donor and transfuse them into the reciepent. Very undramatic. There is still GVHD even with a full matched donor. I have crossed into the dark side. I have decided to go with the BMT or stem cell transplant, whichever you prefer to call it. Gleevec is not my gold, as I have told you before. I am grateful for all the people that are succeeding with it. I wish it had held longer for me. I have a matched donor and I am going for this. I am worn down by side effects and working full time. If I don't cure this, the drugs they are experimenting on me with are going to kill me. I am like you I, I have multiple health issues also. I also work full time and dealing with this is becoming crazy with endless hurdles. Before I have major organ damage from being an experiment, I am going for the cure. The only cure known for this disease. I wish you well, and hope your " gold " holds you forever. I would like to be there to see my daughter Haley graduate from high school in two years. My other daughter Morgen will be graduating from college around the same time. I plan to be there to celebrate with them both. The way treatment is going for me, I think I am making a wise choice, Good luck all. T Stone IAintFinishedYet <kttweety@...> wrote: Hey Group: FYI~~my 2 cents After being given 2-5 months morbid mortality in November 2003. . . After going through HELL and being labeled " Queen of the Side Effects " . . . After being told that CML is no longer a terminal disease, now its a Chronic Disease with a newly diagnosed person having a 25 year median mortality. . . After being told that Gleevec is a maintenance medication. . . After being told that AMS & BMS are not either/or medications for Gleevec; they are for survivors who have became intolerant or failed Gleevec therapy. .. . After knowing survivors die from a BMT; who were otherwise surviving on Gleevec because GVHD is a KILLER. . .or living the Gleevec life again. After being told that CML is a Chronic Disease, much like Diabetes, for which there's no CURE. . . After being told that CML is a Chronic Disease, much like Diabetes, for which there's no CURE. . . After reaching my maximum response, I know that my demise will be from one of my other 20 fatal/terminal/chronic diseases. . .all of which I call Chronic Illnesses. . . I named CML~~ my 'bug'. . . I named Gleevec~~ my 'gold' . . . I named Plavix/Heart Disease~~my 'platinum' I named Pain Medications/Orthopedic Diseases~~my 'silver' After knowing in my heart that the CURE isn't the BMT. . .it will come from SCT~~Stem Cell Transplant. I heard that our President is vetoing the bill again. We need to appeal to our Senators so that they over-ride him. That way the research and development into SCT can forge ahead. In the meantime; I say Thanx God, Dr. Drucker~~Father of Gleevec, Dr. Talpaz~~Father of CML (doing SC research at UMCCC, the only facility in the US), Zavie, , , Anjana, , Skip, etc., for being there for me when I had a question or concern; and I take my 'gold' because. . . " I AM A SURVIVOR. . .I AIN'T FINISHED YET " ! ! ! HAPPY NEW YEAR. . .I have ALL in my prayers. " K " " I AIN'T FINISHED YET " !!! Quote Link to comment Share on other sites More sharing options...
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