Re: bone metabolism

[Guest guest]

I read the comments about the study which showed Gleevec interferes with

some bone metabolism. I just joined a clinical trial at MSKCC which will

monitor 60 Gleevec patients for just that. I have to have a bone density test

on

Friday, and give a urine and blood sample. Then, I'll be monitored every

three months for any bone metabolism problems. I don't think I have any

problems

with this at the present time. I had a bone density test last year and

everything was fine. The clinical trial will check me closely, however. I

decided to join the trial because if any problems develop, they can be found

early,

and I can be put on meds to help the situation.

I do have one concern, however. My albumin has been low. My hematologist

at MSKCC has asked me to see a gastroenterologist again because of this. I

went to the gastro/onc last year. I had an endoscopy/colonoscopy and

everything was fine. I also had a kidney workup, and everything was fine there

too.

I'm a little worried about some liver damage. Has anyone else had low

albumin levels? Should I be worried about liver damage? There are no other

symptoms of liver problems.

in NY

dx. 1/04

400 mg.

[Guest guest]

Hi ,

Please let us know how your trial goes. I'm very glad that they're

doing this study. The more they study, the more questions we get

answered.

You don't say how low your albumin is or if you've had LFT's done. I

would imagine if your liver was at all compromised, the first sign

you would see is an elevated ALP, AST, ALT and Bilirubin. Have you

been checked for protein in your urine?

If your creatinine is fine, you don't have protein in your urine and

all your LFT's are good, then I would try not to worry. Do you eat

enough protein in your diet? It could be as simple as that. It's

always good to see a specialist though, it'll reassure you that

nothing else is going on.

Let us know what happens with the gastroenterologist and the trial

you're on.

Tracey

>

> I read the comments about the study which showed Gleevec interferes

with

> some bone metabolism. I just joined a clinical trial at MSKCC

which will

> monitor 60 Gleevec patients for just that. I have to have a bone

density test on

> Friday, and give a urine and blood sample. Then, I'll be

monitored every

> three months for any bone metabolism problems. I don't think I

have any problems

> with this at the present time. I had a bone density test last

year and

> everything was fine. The clinical trial will check me closely,

however. I

> decided to join the trial because if any problems develop, they

can be found early,

> and I can be put on meds to help the situation.

>

> I do have one concern, however. My albumin has been low. My

hematologist

> at MSKCC has asked me to see a gastroenterologist again because of

this. I

> went to the gastro/onc last year. I had an endoscopy/colonoscopy

and

> everything was fine. I also had a kidney workup, and everything

was fine there too.

> I'm a little worried about some liver damage. Has anyone else had

low

> albumin levels? Should I be worried about liver damage? There are

no other

> symptoms of liver problems.

>

> in NY

> dx. 1/04

> 400 mg.

>

>

>