RE: Need reference for cell metabolism - mineral testing

[Guest guest]

,

I know that if the cells are short of copper they are unable to utilise iron

which may be available.... (so you would get anemic symptoms but with serum iron

ok? ) Zinc works in conjunction with copper and both have to be balanced.

Unfortunately I forgot to bookmark where I found this out.... but perhaps the

extra info might help if you do a search?

.

>

> My endo needs somethign to support running the copper and zinc since they

> are very expensive and outside the norm.

>

>

[Guest guest]

Here

are some links to the reasons why you need to have these levels of certain

vitamins and minerals checked and their connection to your thyroid and

metabolic status.

·

Low iron/ferritin: http://www.thewayup.com/newsletters/081504.htm

and http://www.ithyroid.com/iron.htm

.. I also used the following article in our last TPA Newsletter http://www.femail.com.au/iron-levels-tony-pearce.htm

·

Low vitamin B12: http://www.ncbi.nlm.nih.gov/pubmed/18655403

·

Low vitamin D3:

·

http://www.eje-online.org/cgi/content/abstract/113/3/329

and http://www.goodhormonehealth.com/VitaminD.pdf

·

Low magnesium: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC292768/pdf/jcinvest00264-0105.pdf

·

Low folate:

·

http://www.clinchem.org/cgi/content/full/47/9/1738

and http://www.liebertonline.com/doi/abs/10.1089/thy.1999.9.1163

·

Low copper/zinc: http://www.istanbul.edu.tr/ffdbiyo/current4/07%20Iham%20AM%C4%B0R.pdf

and http://articles.webraydian.com/article1648-Role_of_Zinc_and_Copper_in_Effective_Thyroid_Function.html

It

is essential that you have a correct level of Selenium and Zinc as both are

needed for conversion of the mainly INACTIVE thyroid hormone thyroxine into

the  ACTIVE form of the thyroid hormone T3.

Zinc: An essential trace mineral. The functions of zinc are enzymatic. There

are over 70 metalloenzymes known to require zinc for their functions. The main biochemicals

in which zinc has been found to be necessary include: enzymes and enzymatic

function, protein synthesis and carbohydrate metabolism. Zinc is a constituent

of insulin and male reproductive fluid. Zinc is necessary for the proper

metabolism of alcohol, to get rid of the lactic acid that builds up in working

muscles and to transfer it to the lungs. Zinc is involved in the health of the

immune system, assists vitamin A utilization and is involved in the formation

of bone and teeth.

Hypo-and

hyperzincemia has been reported to cause alterations in the adrenal secretion.

To determine the acute effect of zinc on cortisol levels, we studied 27 normal

individuals of both sexes aged 20–27 y after a 12-h fast. The tests were

initiated at 7:00am when an antecubital

vein was punctured and a device for infusion was installed and maintained with

physiological saline. Zinc was administered orally at 8:00am. Subjects were divided into an

experimental group of 13 individuals who received doses of 25, 37.5, and 50 mg

of zinc and a control group of 14 individual who received 20 mL of

physiological saline. Serial blood samples were collected over a period of 240

min after basal samples (−30 and 0 min). We detected an acute inhibitory effect

of zinc on cortisol secretion during 240 min of the study period in the

experimental group.

Circadian

variations in plasma zinc and cortisol in man.

Couturier

E, van

Onderbergen A, Bosson

D, Neve

J.

Laboratory

of Experimental Medicine, Faculty of Medicine, University of Brussels, Belgium.

Abstract

Circadian

variations of zinc and cortisol concentrations in plasma were studied in six

healthy adult men. Three of them were tested over two different 24-h periods.

Results were analyzed by computerizing a best-fit curve for each 24-h profile.

Plasma zinc displayed a morning peak between 8.00 and 9.00 a.m. followed by an

almost linear decline throughout the day with lowest values observed shortly

before 6.00 p.m. A transitory increase occurred between 6.00 p.m. and 8.00 p.m.

followed by a slow decrease reaching its nadir around midnight. Thereafter zinc

increased steadily until 8.00 a.m. A similar profile was observed in a seventh

subject who was undergoing therapeutic starvation for obesity (fifth day of the

starvation period). In all subjects the time course of plasma cortisol

fluctuations paralleled that of zinc. Our results confirm the existence of a

circadian rhythm in plasma zinc independent of zinc intake and temporally

related to the circadian rhythm of cortisol.

From: thyroid treatment

[mailto:thyroid treatment ] On Behalf Of

hurley

Sent: 01 March 2011 13:19

thyroid treatment ; thyroidless ;

graves_support

Subject: Need reference for cell metabolism -

mineral testing

Looking for specific reference article(s) for pulling blood

on the 5 minerals? [ferritin, D3, B12, magnesium, folate, copper, zinc]

My endo needs somethign to support running the copper and

zinc since they are very expensive and outside the norm.

I'm reading through the thread below and see RT3, but

nothing on the minerals...

thank you in advance,

LH*

[Guest guest]

Sheila, thank you so much - this will prove an immense help when arguing a case

for these tests to be done as most endos/drs do not know this. It is already

practically impossible to get the copper test done because it is apparently too

expensive.

Is there anyway we could have this (with links) in a special section in the

files menu, under a heading of some sort, eg " The 9 most important vitamins and

minerals you should ask your doctor to check " ,

Thank you again for your relentless and selfless support for this cause.

Love

Jacquie

>

> Here are some links to the reasons why you need to have these levels of

certain vitamins and minerals checked and their connection to your thyroid and

metabolic status.

[Ed]

[Guest guest]

Hi Jacquie

Yes, this is something I started to do but never really got

around to completing it. Such a document would be so useful for patients and

doctors alike, but I am so busy I never really get the time to do everything

that is needed.

If anybody wishes to volunteer to put something together (not

too long because doctors simply will not read it) to tell them WHY people

suffering the symptoms of hypothyroidism need the following blood tests, giving

links to the scientific evidence to show the association with low levels of

specific minerals and vitamins, this would be such a massive help.

The minerals and vitamins concerned are ferritin, folate,

magnesium, copper, zinc, vitamin B12 and vitamin D3.

Luv - Sheila

Is there anyway we could have this (with links) in a special section in the

files menu, under a heading of some sort, eg " The 9 most important

vitamins and minerals you should ask your doctor to check " ,