Guest guest Posted January 25, 2011 Report Share Posted January 25, 2011 I believe there's a risk for low zinc with hydrocortisone. Bob > > Hi Everyone > > I've just received a letter from my GP saying that my recent Zinc blood test shows a result of 9.9 (range 11 - 24), and that she will prescribe Zinc supplements. > > Does anyone know: > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 26, 2011 Report Share Posted January 26, 2011 Hi, I don't get zinc prescribed though I have supplemented it for years. zinc is vital along with other vits and mierals for the conversion of T4 to T3- I'm not sure where along the line it becomes involved, so I wouldn't be surprised if raising zinc levels helps with absorption of T3.As far as I'm aware there are no bad interactions, but i do take it with lunch so it is some hours after I take my thyroid meds- I take all my sulpplements together and some will interfere with thyroid meds -such as calcium and iron. > thyroid treatment > From: l.mcnamara@...> Date: Tue, 25 Jan 2011 19:38:12 +0000> Subject: Zinc - T3 Intolerance> > Hi Everyone> > I've just received a letter from my GP saying that my recent Zinc blood test shows a result of 9.9 (range 11 - 24), and that she will prescribe Zinc supplements.> > Does anyone know:> > Would this result cause the T3 intolerance symptoms I have been suffering with? (I do have low ferritin which I am treating and I know this doesn't help).> > Also, does anyone take Zinc supps prescribed for them? Is there anything I should be aware of re dosing/interactions/etc?> > Finally, could low Zinc cause the really bad fatigue/low energy I have had for past few weeks, which seems to be getting worse? > > ps I take 30mg Cortef plus 5 x Nutri Adrenal daily.> > Sorry for all the questions, thanks for any replies> > Liesha> > > > ------------------------------------> > TPA is not medically qualified. Consult with a qualified medical practitioner before changing medication.> > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 26, 2011 Report Share Posted January 26, 2011 Hi there Sorry to hear that you have low zinc levels - I had/have the same - very very low - I have to take supplements - I usually take zinc citrate as it is easier for absorption - this deficiency is in my opinion something you have to live with livelong and be aware of - you will need to get your GP to check your levels every 3 months to see if it is getting through. How does it happen - it could be lost via the kidney or more usually because you are low on Vitamin A - zinc cannot be transported through the body - your GP should check your A levels as the two go together. Zinc can be quite corrosive to the tummy and can also be affected by carbohydrate consumption if you have a carbohydrate meal near when you take your supplement then the carbs will gobble it up and you will lose absorption. You will need to take at least 15 mg of zinc to get it through - but it is important that you get your GP to check your A levels (not sure if they do that test - but they should) normally A and low D go together as well. Anything else I can help with just ask. See below American Journal of Clinical Nutrition, Vol 34, 1489-1495, Copyright © 1981 by The American Society for Clinical Nutrition, Inc ORIGINAL RESEARCH COMMUNICATIONS The interrelationship of thyroid hormones with vitamin A and zinc nutritional status in patients with chronic hepatic and gastrointestinal disorders JE Morley, RM , A , EA Carney and JM Hershman To define the role of vitamin A, retinol binding protein, and zinc deficiency in producing the thyroid hormone abnormalities found in chronic illness, we studied 62 clinically stable patients with hepatic and gastrointestinal disorders. Serum triiodothyronine (T3) and free T3 index (FT3I) were depressed compared to controls (p less than 0.05) in the patients. Retinol binding protein and prealbumin levels correlated with both T3 and FT3I (p less than 0.01), whereas vitamin A levels did not. Vitamin A therapy in patients with documented vitamin A deficiency produced an increase in T3, thyroxine (T4), FT3I, FT4I, and free T3 by dialysis, with a concomitant increase in retinol binding protein and no alteration in prealbumin concentrations. Zinc-deficient patients had significantly depressed T3 and FT3I (p less than 0.001) and increased prolactin levels (p less than 0.01). Zinc supplementation failed to return any of these parameters to normal. Vitamin A therapy in normals produced a transient decrease in T3 and T4 after 1 wk of therapy, but after a further 2 wk, thyroid function returned to normal. Our data suggest a causal relationship between the pathogenesis of deranged vitamin A-retinol binding protein metabolism and the low T3 syndrome either by interfering with T4 entry into tissues or by directly affecting the enzymatic conversion of T4 to T3. Best wishes Mandy Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 26, 2011 Report Share Posted January 26, 2011 Thanks, Bob, I haven't heard that before. Liesha > > I believe there's a risk for low zinc with hydrocortisone. > > Bob Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 28, 2011 Report Share Posted January 28, 2011 Wow, Mandy, thanks very much for all this info - I just need to get my foggy brain to process it now! And it really helps for when I speak to my GP soon, to get the zinc supplements. Thanks again Liesha > > Hi there, > > Hope this helps too. > > Best wishes > > Mandy > > > Zinc > An essential trace mineral. The functions of zinc are enzymatic. There are over 70 metalloenzymes known to require zinc for their functions. The main biochemicals in which zinc has been found to be necessary include: enzymes and enzymatic function, protein synthesis and carbohydrate metabolism. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 29, 2011 Report Share Posted January 29, 2011 Mandy, can you post a link to this information please. Luv - Sheila Zinc An essential trace mineral. The functions of zinc are enzymatic. There are over 70 metalloenzymes known to require zinc for their functions. The main biochemicals in which zinc has been found to be necessary include: enzymes and enzymatic function, protein synthesis and carbohydrate metabolism. Zinc is a constituent of insulin and male reproductive fluid. Zinc is necessary for the proper metabolism of alcohol, to get rid of the lactic acid that builds up in working muscles and to transfer it to the lungs. Zinc is involved in the health of the immune system, assists vitamin A utilization and is involved in the formation of bone and teeth. Hypo-and hyperzincemia has been reported to cause alterations in the adrenal secretion. To determine the acute effect of zinc on cortisol levels, we studied 27 normal individuals of both sexes aged 20–27 y after a 12-h fast. The tests were initiated at 7:00am when an antecubital vein was punctured and a device for infusion was installed and maintained with physiological saline. Zinc was administered orally at 8:00am. Subjects were divided into an experimental group of 13 individuals who received doses of 25, 37.5, and 50 mg of zinc and a control group of 14 individual who received 20 mL of physiological saline. Serial blood samples were collected over a period of 240 min after basal samples (−30 and 0 min). We detected an acute inhibitory effect of zinc on cortisol secretion during 240 min of the study period in the experimental group. Circadian variations in plasma zinc and cortisol in man. Couturier E, van Onderbergen A, Bosson D, Neve J. Laboratory of Experimental Medicine, Faculty of Medicine, University of Brussels, Belgium. Abstract Circadian variations of zinc and cortisol concentrations in plasma were studied in six healthy adult men. Three of them were tested over two different 24-h periods. Results were analyzed by computerizing a best-fit curve for each 24-h profile. Plasma zinc displayed a morning peak between 8.00 and 9.00 a.m. followed by an almost linear decline throughout the day with lowest values observed shortly before 6.00 p.m. A transitory increase occurred between 6.00 p.m. and 8.00 p.m. followed by a slow decrease reaching its nadir around midnight. Thereafter zinc increased steadily until 8.00 a.m. A similar profile was observed in a seventh subject who was undergoing therapeutic starvation for obesity (fifth day of the starvation period). In all subjects the time course of plasma cortisol fluctuations paralleled that of zinc. Our results confirm the existence of a circadian rhythm in plasma zinc independent of zinc intake and temporally related to the circadian rhythm of cortisol. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 29, 2011 Report Share Posted January 29, 2011 http://www.ncbi.nlm.nih.gov/pubmed/2980824 Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 29, 2011 Report Share Posted January 29, 2011 http://www.springerlink.com/content/x4mxl42332033802/ http://www.ncbi.nlm.nih.gov/pubmed/2980824 Quote Link to comment Share on other sites More sharing options...
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