Thyroid antibodies and pregnancy

[Guest guest]

Hi,

Interesting article I came across in the Journal of Clinical Endocrinology on

the effects on pregnancy of thyroid antibodies on euthyroid patients(people with

normal thyroid gland function) - published online March this year, appearing in

print in the June 11 issue of JCEM.

Thyroid Antibody Positivity in the First Trimester of Pregnancy Is Associated

with Negative Pregnancy Outcomes

o Negro,

Alan Schwartz,

Riccardo Gismondi,

Tinelli,

Tiziana Mangieri and

Stagnaro-Green

Abstract

Context: Thyroid antibody positivity during pregnancy has been associated with

adverse outcomes including spontaneous miscarriage, recurrent miscarriage, and

preterm delivery.

Objective: The objective of the study was to determine whether thyroid antibody

positivity in the first trimester of pregnancy in euthyroid women was associated

with maternal and neonatal adverse outcomes.

Design: The present trial is a component of a prospective trial published in

2010 that evaluated screening for thyroid disease during pregnancy and the

impact of levothyroxine therapy in women who were thyroid peroxidase positive

with a TSH above 2.5 mIU/liter. The present study compared 14 maternal and

neonatal adverse outcomes in 245 women who were euthyroid (TSH < 2.5 mIU/liter)

and thyroid peroxidase positive in the first trimester to 3348 women who were

euthyroid and thyroid peroxidase negative in the first trimester.

Setting: The study was conducted in southern Italy at the ambulatory clinics of

two community hospitals.

Patients: The study consisted of 3593 women.

Intervention: There was no intervention.

Main Outcome Measures: The main outcome measures were 14 maternal and neonatal

complications.

Results: The main result was an increase in very preterm delivery (<34 wk

gestation at delivery) [4.5 vs. 1.8%; & #967;2(df = 1) = 8.58; P = 0.003] and

respiratory distress [3.3 vs. 1.2%; & #967;2(df = 1) = 7.80; P = 0.005] in women

who were thyroid antibody positive.

Conclusions: The present study provides further evidence of an association

between thyroid antibody positivity and very preterm delivery in euthyroid

women. The association with respiratory distress should be considered

preliminary and awaits further study.

[Guest guest]

Hi Nadia, please can you give me the link to this article.

Luv - Sheila

Interesting article I came across in the Journal of Clinical Endocrinology on

the effects on pregnancy of thyroid antibodies on euthyroid patients(people

with normal thyroid gland function) - published online March this year,

appearing in print in the June 11 issue of JCEM.

Thyroid Antibody Positivity in the First Trimester of Pregnancy Is Associated

with Negative Pregnancy Outcomes

[Guest guest]

Here is the link:

http://jcem.endojournals.org/content/96/6/E920.abstract?sid=7db446b6-3ee6-4c2d-9\

f6b-d00638a2b6b1

Can't get the full article without a subscription unfortunately.

Nadia

>

> Hi Nadia, please can you give me the link to this article.

>

> Luv - Sheila

>

>

>

> Interesting article I came across in the Journal of Clinical Endocrinology

> on the effects on pregnancy of thyroid antibodies on euthyroid

> patients(people with normal thyroid gland function) - published online March

> this year, appearing in print in the June 11 issue of JCEM.

>

> Thyroid Antibody Positivity in the First Trimester of Pregnancy Is

> Associated with Negative Pregnancy Outcomes

>