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Reactions to thyroxine

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I have recently started taking thyroxine, after years of chronic exhaustion etc

diagnosed as chronic fatigue syndrome. (I've probably had an underactive

thyroid most of my life as I was told I was borderline many years ago at age

11).

I'd be interested to know if my reaction to taking thyroxine is similar to

anyone else's.

My doctor is gradually increasing my dose in 25 mcg doses and reviewing with

blood tests and an appointment after a month.

The first month on 25 mcg started ok, but by the end of the month I was feeling

much worse, very drugged and able to do little but sleep. I assumed it was a

problem with the brand. I changed brand when I got my new prescription for 50

mcg and started to feel quite a bit better so thought this confirmed my previous

problems were brand-related.

However, now I'm into the third week of 50 mcg of the new brand, I am again

getting that very groggy, want to sleep all the time feeling.

I wonder if anyone else has had a similar experience? Is this part of the

adjustment period?

(I am aware that I will probably have to look at the adrenal side of things

outside the nhs at some point soon, but at the moment I am doing things the

doctor's way to keep him on side and so that I have thoroughly explored the

conventional route first).

Many thanks for your help.

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