Re: basic thyroid hormone questions - maybe for ?

[Guest guest]

Hi im not paul or a mod, but i have some information regarding RT3 which i found

really usefull.

RT3 is from back in the day when we had to catch our own food to eat (cavemen

times, hunting ect ect) and it was to stop us from starving by slowing down the

metabolism. If you didnt catch any food or was too ill to catch food, then the

body would start converting T4 > RT3 instead of T4 > T3 therefore slowing down

the metabolism, slowing everything down giving us longer before the next meal.

Now in this day and time T4 is converted to RT3 when something is not quite

right in the body which aids the conversion, such as low adrenal reserve, or low

iron/ferritin or mercury ect ect

I hope this helps anyhow

Steve

> Some basic questions I am trying to get my head round concerning rT3:

>

> If reverse-T3 is produced when the body believes it has too much T4 or T3, why

doesn't the body reduce TSH instead? Or does it do both at the same time - in

which case high rT3 would always appear alongside low TSH (unless of course

something else was simultaneously increasing TSH)?

>

> Also, it is the pituitary that " decides " to reduce TSH. What is it that

" decides " to convert T4 to rT3 ?

>

> I am mainly concerned with thyroid resistance, not primary problems.

>

> I hope you know the answers or any other mod out there!

[Guest guest]

MODERATED TO REMOVE MOST OF PREVIOUS MESSAGE: PLEASE REMOVE MOST OF THE MESSAGE

YOU'RE RESPONDING TO BEFORE POSTING.

THANK YOU.

MODERATOR

Hi Steve,

Thanks for your reply, but what I am really trying to find out is why rT3 can be

raised due to cellular resistance. i.e. what is the mechanism that causes the

body to say " okay T3 isn't getting into the cells so I'm going to convert some

T4 to rT3 " ? If there is too much T3 in the blood cue to pooling (due to it not

getting into cells) I can see that the body would say we've got too much T3 so

I'm going to divert some incoming T4 to rT3 instead. But in that case cellular

resistance might show up as high T3 ? Well not necessarily, if enough T4 is

diverted to rT3 maybe the T3 normalises and the rT3 is raised...maybe I just

answered my own question!

Cheers,

Mark

>

> Hi im not paul or a mod, but i have some information regarding RT3 which i

found really usefull.

[Guest guest]

what's the reasoning behind needing to know?

i think you can get bogged down in all the minutiae of this if you're not

careful (been there, done that)

Dr Lowe talks about resistance a bit here:

http://www.drlowe.com/QandA/askdrlowe/resistnc.htm

Chris

>

> > Thanks for your reply, but what I am really trying to find out is why rT3

can be raised due to cellular resistance. i.e. what is the mechanism that causes

the body to say " okay T3 isn't getting into the cells so I'm going to convert

some T4 to rT3 " ?

[Guest guest]

The mechanism is the body will identify there is too much T4 circulating the body and so will turn the T4 into rT3 thus neutralising it for the time being. So the body doesnt realise there isnt enough Thyroid hormone at the cellular level just that there is too much circulating. Of course rT3 can be converted to T2 which is an active hormone, but the rT3 is useful for the body when for some reason too much T4 is circulating.

But I agree with dont get bogged down with that stuff. However, if you wanna know more look at the rT3 website it has dynamic detail if you want it. Sally xx

>> > Thanks for your reply, but what I am really trying to find out is why rT3 can be raised due to cellular resistance. i.e. what is the mechanism that causes the body to say "okay T3 isn't getting into the cells so I'm going to convert some T4 to rT3"?

[Guest guest]

Hi,

I read an article by Dr P, which said that when there is unconverted t4 which

needs to be disposed of, it was broken down by the body into it's component

parts, so that the iodine coud be reused.

Hence being broken down into T3, T2 and T1. BUT, if the T4 was broken down

inton T3 we wouold be hyper, so it's made into reverse t3 instead.

Here is the link to the article which is the files section

thyroid treatment/files/RT3%20%20WHAT%\

20SHOULD%20WE%20DO%20ABOUT%20IT/

..

> If reverse-T3 is produced when the body believes it has too much T4 or T3, why

doesn't the body reduce TSH instead?

[Guest guest]

You are right Steve,

It was for the winter months we we needed to hybernate due to low food supplies...bears have the same thing their levels of rT3 increase in the winter when they hybernate, thus slowing the body enabling them to sleep for longer periods to have a low appetite and to use very little energy at the cellular level.

Sally xx

Hi im not paul or a mod, but i have some information regarding RT3 which i found really usefull.RT3 is from back in the day when we had to catch our own food to eat (cavemen times, hunting ect ect) and it was to stop us from starving by slowing down the metabolism. If you didnt catch any food or was too ill to catch food, then the body would start converting T4 > RT3 instead of T4 > T3 therefore slowing down the metabolism, slowing everything down giving us longer before the next meal.

[Guest guest]

Thanks Sally, I have read through that site but it disagrees with Dr P's

opinion, so I am trying to figure out which is right....

Cheers,

Mark

>

>

>

> You are right Steve,

> It was for the winter months we we needed to hybernate due to low food

supplies...bears have the same thing their levels of rT3 increase in the winter

when they hybernate, thus slowing the body enabling them to sleep for longer

periods to have a low appetite and to use very little energy at the cellular

level.

>  

>

[Guest guest]

Similar to Lowe's theory also - http://www.drlowe.com/QandA/askdrlowe/thymetab.htm

Luv - sheila

I read an article by Dr P, which said that when there is unconverted t4 which

needs to be disposed of, it was broken down by the body into it's component

parts, so that the iodine coud be reused.

Hence being broken down into T3, T2 and T1. BUT, if the T4 was broken down

inton T3 we wouold be hyper, so it's made into reverse t3 instead.

Here is the link to the article which is the files section

thyroid treatment/files/RT3%20%20WHAT%20SHOULD%20WE%20DO%20ABOUT%20IT/

..

> If reverse-T3 is produced when the body believes it has too much T4 or T3,

why doesn't the body reduce TSH instead?

[Guest guest]

Thanks . See this is the thing - Dr P says rT3 is a RESULT of thyroid

resistance not the CAUSE. The rT3 website says the opposite. So I'm trying to

figure out which is right, because it will have some bearing on my treatment...

Cheers,

Mark

>

>

> Hi,

>

> I read an article by Dr P, which said that when there is unconverted t4 which

needs to be disposed of, it was broken down by the body into it's component

parts, so that the iodine coud be reused.

>

> Hence being broken down into T3, T2 and T1. BUT, if the T4 was broken down

inton T3 we wouold be hyper, so it's made into reverse t3 instead.

>

>

> Here is the link to the article which is the files section

>

>

thyroid treatment/files/RT3%20%20WHAT%\

20SHOULD%20WE%20DO%20ABOUT%20IT/

>

> ..

[Guest guest]

Hi again

See what doesn't make sense to me is, if rT3 does block receptors, then, since

rT3 has the same short half-life as T3 (0.75days), once you suppress rT3 (by

going on T3 only) then the rT3 should be out of the system quickly. But it

usually takes an extra 4 weeks, which to me says rT3 blocking the receptors

can't be the cause....

An alternative is that rT3 is produced due to pooling (caused itself by cellular

resistance). People who need to " clear " rT3 always seem to need to be on

supraphysiological doses of T3 afterwards, which means they must have cellular

resistance not caused by rT3 blocking receptors...

Mark

>

> what's the reasoning behind needing to know?

>

> i think you can get bogged down in all the minutiae of this if you're not

careful (been there, done that)

>

> Dr Lowe talks about resistance a bit here:

>

> http://www.drlowe.com/QandA/askdrlowe/resistnc.htm

[Guest guest]

Hi again

See what doesn't make sense to me is, if rT3 does block receptors, then, since

rT3 has the same short half-life as T3 (0.75days), once you suppress rT3 (by

going on T3 only) then the rT3 should be out of the system quickly. But it

usually takes an extra 4 weeks, which to me says rT3 blocking the receptors

can't be the cause....

An alternative is that rT3 is produced due to pooling (caused itself by cellular

resistance). People who need to " clear " rT3 always seem to need to be on

supraphysiological doses of T3 afterwards, which means they must have cellular

resistance not caused by rT3 blocking receptors...

Mark

> what's the reasoning behind needing to know?

[Guest guest]

Rt3 has shorter half life, see this article

http://jcem.endojournals.org/content/90/8/4559.full

Are you trying to work out why you're not getting better or something?

Have u checked what I've mentioned before, vit a, vit d, Pregnenolone,

progesterone, testosterone, dhea, copper, ferritin etc? Sorry on my Google phone

so can't write much or check what else you've tried

C

>

> Hi again

>

> See what doesn't make sense to me is, if rT3 does block receptors, then, since

rT3 has the same short half-life as T3 (0.75days), once you suppress rT3 (by

going on T3 only) then the rT3 should be out of the system quickly. But it

usually takes an extra 4 weeks, which to me says rT3 blocking the receptors

can't be the cause....

[Guest guest]

Yes but maybe its something else - not Rt3 or resistance but Rt3 / resistance as

a consequence of....x or y

I'd do a load more tests. You may be looking at the wrong thing/hormone

entirely.

>

> Thanks . See this is the thing - Dr P says rT3 is a RESULT of thyroid

resistance not the CAUSE. The rT3 website says the opposite. So I'm trying to

figure out which is right, because it will have some bearing on my treatment...

>

[Guest guest]

Hi

Thanks for the article.

Yeah I have checked or am checking the things you mention. I just want to

understand what is causing resistance, is it rT3 or is it something else. I am

taking 87.5mcg T3 and I feel nothing, so I must have some massive resistance!

[Guest guest]

Im pretty sure that its impossible for T3 > RT3 as once its T3 it is the active

hormone, with RT3 being the inactive hormone. So T3 pooling cannont cause RT3.

Most people need between 75-125mcg of T3 AFTER clearance which is normal and not

supraphysiological for people on T3 only.

The reasoning for it taking 12 weeks to clear RT3, is that you need to get your

T4 low enough so that it cannont convert as much T4 > RT3 so you can clear the

receptors, which according to the RT3 website takes around 12 weeks, and for me

it took around 14 weeks.

Theres alot of info on here if you have time to read it.

http://thyroid-rt3.com/

Steve

>

> Hi again

> An alternative is that rT3 is produced due to pooling (caused itself by

cellular resistance). People who need to " clear " rT3 always seem to need to be

on supraphysiological doses of T3 afterwards, which means they must have

cellular resistance not caused by rT3 blocking receptors...

>

> Mark

>

>

> > what's the reasoning behind needing to know?

>

[Guest guest]

I had quite bad RT3 and as soon as i took my first T3 tablet i noticed a HUGE

improvement.

Have you checked your adrenals/iron levels as if they are both low T3 will not

do much or give intolerance symptoms.

Steve

>

> Hi

>

> Thanks for the article.

> Yeah I have checked or am checking the things you mention. I just want to

understand what is causing resistance, is it rT3 or is it something else. I am

taking 87.5mcg T3 and I feel nothing, so I must have some massive resistance!

>

[Guest guest]

Hi Mark

So you feel nothng at all from 87.5mcg t3? no change in pulse, temps etc?

interesting.

i have read that low growth hormone can increase T4 > Rt3 conversion.

if you don't respond 'as you should' it seems hard to sort out, deosn't it.

i have the opposite problem to you - i am intolerant to even small amounts of

thyroid hormone.

but, i got tested and found out i had low copper, ferritin, Vitamin A, D3, and

also started on pregnenolone, DHEA. why i mention this is that after starting

this i got the symptoms of hypothyroidism. so that indicates to me that perhaps

some of these things affect the thyroid or rather i should say how it's used in

the body.

i gather even things like potassium can affect how much thyroid we can use?

did you tell me/us what you'd checked so far?

>I just want to understand what is causing resistance, is it rT3 or is it

something else.

well what do you think? do you not think that rt3 would have started to clear

by now? i was told that rt3 just meant that the body can't use the t3. so i'd

be looking at any/all of the reasons for this, including essential fats,

vitamins, anything really. including adrenal support. so perhaps your cells

can't uptake the thyroid - what causes this problem?

could it be you have too much TBG?

what do you take?

if you want someone to bounce ideas off , feel free.

one thing i always remember when looking at this stuff (and other things) is

'push where it moves'. not ncessarily, but often, i think taking a hormone or

steroid brings about a rapid change. if it doesn't after a reasonable trial,

then i start to wonder 'what else is going on here', not just keep trying the

same thing harder and harder.

chris

this is a good article; This is a good article:

http://ezinearticles.com/?The-Ultimate-Strategy-For-Solving-Thyroid-Disorder-Sym\

ptoms & id=5822925

i've posted it all:

The Ultimate Strategy For Solving Thyroid Disorder Symptoms

By Dr. Karl R.O.S. , DC

quantities of TSH and therefore the thyroid gland is not stimulated adequately

to produce T4 and T3. One common way that this occurs is from chronic stress.

Sampling of Stressors That Negative Impact The Thyroid Gland Include:

•Chronic stress fatigues the pituitary gland

•Hormone pills including Synthroid & estrogen creams

•Liver dysfunction

•Inadequate sleep

•Inflammation & Infection

•Toxicity (mercury, gluten, casein, flu shot)

•Poor nutrition (Standard American Diet = S.A.D.)

•Postpartum depression; pregnancy can fatigue the pituitary gland

•Fluctuating insulin/glucose levels (adrenal gland fatigue)

How do we know this second pathway is malfunctioning? Blood testing reveals TSH

is less that 1.8 and T4 is less than 6.

The third pattern is thyroid under conversion. This is when the gland is making

enough quantity of T4 but the conversion to T3 is inadequate and therefore there

is low T3. The reason for this reduced conversion can be due to chronic

infection or inflammation. Increased cortisol produced by the adrenal gland that

is responding to stress from a chronic infection or otherwise may also cause

this. High cortisol levels are also toxic to the temporal lobe of the brain

causing poor memory and mental fogginess. This pattern is often missed because

low T3 doesn't affect TSH levels (only T4 does) and T3 is rarely checked for

with the standard blood tests performed by medical physicians. A clue to this

pattern is that all other thyroid tests are normal except T3 is low (300-450 is

normal).

The fourth pattern to cause low thyroid symptoms is thyroid over conversion of

T4 to T3. This can be due to decreased Thyroid Binding Globulin (TBG). This

pattern occurs when too much T3 is made and it is overwhelming the cells. The

number one cause of this pattern (especially in women) is high blood sugar

(glucose) due to a resistance to insulin (the hormone produced by the pancreas

whose job is to usher sugar into our body cells for energy processes). Glucose

will typically be found in the 100-126 and higher range. Increased glucose

causes increases testosterone levels in females resulting in too much free T3

and too little TBG. Insulin resistance due to over consumption of carbohydrates

is also a very common cause of polycystic ovarian syndrome (PCOS) and subsequent

difficulty getting pregnant (infertility).

The fifth pattern is Thyroid Binding Globulin (TBG) elevation. This is when

there is too much TBG in the blood and too little T3. When TBG is too high, it

is like having too many taxis for T3 hormone and the taxis won't let out their

passengers, because they are concerned they won't get other passengers. This is

mainly caused by oral contraceptives. Oral contraceptives or estrogen

replacement therapy causes an increase in estrogen, which leads to increases in

TBG.

The sixth pattern is thyroid resistance. With thyroid resistance chronic stress

is a root cause. Chronic stress stimulates the adrenal glands, which, in turn,

produces far too much cortisol. High levels of cortisol from the adrenal gland

cause cells throughout the body to be resistant to thyroid hormones. The

pituitary and thyroid are ok but the hormones are not getting into the cells.

Many parts of the body become involved when thyroid function is interfered with

including bone metabolism, the immune system, the nervous system, the endocrine

system, gastrointestinal function, liver and gallbladder, growth and sex

hormones, fat burning, insulin and glucose metabolism, healthy cholesterol

levels and proper stomach acid. Sometimes the thyroid gland will not produce

enough hormones and this is called hypo-secretion. On the other hand, it can

produce too many and this is called hyper-secretion. There is a normal level of

secretion and a delicate balance that must be kept. If, for example, there is a

hypo-secretion of the thyroid gland the nervous system will be affected and

people will have mental dulling, depression and memory impairment. If there is a

hyper-secretion of the thyroid gland then a person will experience irritability,

restlessness and moodiness. In the cardiovascular system hypo-secretion will

cause low heart rate and blood pressure and hyper-secretion will cause rapid

heart rate and possible palpitations. The thyroid is so important that when it

malfunctions you will find that many of your body systems are affected.

The bottom line is that poor testing leads to improper treatment, which in turn

leads to poor results. If the diagnosis is incorrect then the treatment will be

ineffective. More often than not a TSH test is ordered to evaluate thyroid

function but there are many other tests to consider when understanding the

condition of your thyroid. For example, the list below is a list of tests that

can produce a much more accurate reflection of thyroid hormone function.

•Total T4: Thyroxine (inactive thyroid hormone)

•Total T3: Triiodothyroxine (the active thyroid hormone)

•FTI: Free Thyroxine index (amount of T4 available)

•FT4: Free Thyroxine (non-protein bound inactive thyroid hormones)

•TBG levels: Thyroid Binding Globulin (the protein " taxi " that shuttles T4 and

T3 around the body)

•T3 Uptake: (how much of T3 is taken up by TBG)

•FT3: Free Triodothyroxine (non-protein bound active thyroid hormones)

•rT3: Reverse T3 (the body cannot use this variation of T3)

•TPO Antibodies (TPO Ab) and TBG Antibodies (TBG Ab): (Indicator of Hashimoto's)

•TSH antibodies: (Indicator of Graves' disease)

In order to know the underlying cause of your thyroid malfunction one must run

the proper tests. It is unwise to just treat the symptoms (that's reserved for

medical treatment). A very important note: If you have an autoimmune attack on

your thyroid gland - then this immune system challenge becomes the HIGHEST

PRIORITY of testing and treatment. To handle this immune system imbalance

requires specialized testing and treatment by a doctor who has been thoroughly

trained in the proper protocols. The first thing we have to do is run a complete

metabolic profile. This includes a complete thyroid profile. Also we must test

for vitamin D levels (both active and storage form), anemia, liver and kidney

function. The second thing we must do is check for immune imbalance. We must

give you an adrenal stress index test. A food sensitivity test must also be

given testing for immune reaction to gluten, milk, soy, yeast and eggs as well

as testing for gluten sensitivity genes and celiac genes[3].

Recent advancement in testing allows us to test the gluten sensitive individual

to 24 foods that can cross react with the gluten (gliadin) antibody. If you are

avoiding gluten, but are still creating an immune response to one of these other

common foods, then you will not get better. So this cross reaction test is very

important. We must also check for gut infections and if you are harboring

parasites and/or yeast overgrowth. Other factors related to digestive system

health must be measured as well (20 percent of T4 to T3 conversion occurs in the

gut). Without a healthy digestive tract you can miss out on as much as 20% of

your intended thyroid hormone function! The main point to keep in mind with this

thorough testing is the thyroid gland influences many bodily functions AND many

systems of the body impact the thyroid gland function. This two-way street is

often referred to as thyroid cross-talk. Taking a whole body approach to testing

for why you have thyroid symptom is the only way to fully evaluate this disorder

so a resolution can come about.

Another very important point is that your specific lab tests need to be

evaluated and analyzed as a group. Once analyzed from this all-inclusive

perspective a Neuro-Metabolic Treatment (NMT) plan should be geared around four

key elements:

1. Dietary changes to eliminate those foods that may be contributing to your

condition. Certain herbs and foods can have a negative effect on the balance of

your immune system. Specific dietary advice should be given so that your immune

system regains balance.

2. Lifestyle changes are necessary to reduce stress on various body systems and

glands. For example; eating 5 meals per day to maintain steady blood sugar

levels so your adrenal glands have a chance to heal. One of the jobs the adrenal

glands have is to balance blood sugar between meals and when under stress.

Taking this job away by eating 5-6 smaller meals lets the adrenals rest up and

rebuild.

3. Along with diet and lifestyle changes there are specific nutritional

supplements that must be taken in order to facilitate healing and recovery. The

consumption of these nutritional supplements will ensure that the repair process

goes smoothly and that the immune system is brought back into balance.

4. Finally a customized and carefully monitored Brain Based Therapy protocol,

designed especially for the thyroid disorder patient, based on a functional

neurological examination is in order.

This 4 prong approach provides the foundation for assisting the malfunctioning

body to bring itself back into balance so it can heal the cause(s) of your

thyroid symptoms. Hopefully now you understand what it takes to really get to

the bottom of your various thyroid malfunction symptoms (sleep problems,

fatigue, pain, ill health, cold hands and feet, brain fog, depression, anxiety,

muscle weakness, etc.) and finally get you feeling more like you used to feel!

References:

[1] Autoimmunity and hypothyroidism. Baillieres Clin Endocrinol Metab. 1988

Aug;2(3):591-617.

[2] Am. J. Med. Volume 123, Issue 2, Pages 183.e1-183.e9

[3] Multiple common variants for celiac disease influencing immune gene

expression. Nature Genetics 42, 295 - 302(2010) Published online: 28 February

2010 | Corrected online: 12 March 2010 | doi:10.1038/ng.543

Dr. Karl R.O.S. is a chiropractic physician and medical writer in Shelby

Township, Michigan. Dr. 's areas of expertise include chiropractic,

functional medicine, functional neurology and spinal rehabilitation. He is the

author of the " Ultimate Strategy " series of eBooks on the topics of;

fibromyalgia, balance disorders, migraine and other debilitating headaches and

well as unresolved thyroid symptoms. For more information and to receive my FREE

informative thyroid answers DVD, free report and eBook entitled: " The Ultimate

Strategy for Ending Your Thyroid Symptoms so You Increase The Zest in Your Life "

please visit ShelbyThyroidAnswers.com or call 586-731-8840.

Article Source: http://EzineArticles.com/5822925

[Guest guest]

Hi , one reason is that may be the T4 to T3 is interrupted because of binding or non binding, why this happens could be due to auto-antibodies or other reasons that i am not aware of.the way it works is a hormone needs to be unbound to work. if it is bound then it can not get into the cells. this could then be RF3 Angel.

[Guest guest]

Hi Steve,

Thansk for the link, but I already read that whole site and couldn't find the

answer. You are right T3 can't be converted to rT3, but T4 might be diverted to

rT3 if T3 is pooling to stop even more pooling.

That's what I'm saying - if people need 75-125mcg AFTER, then it can't be the

rT3 that was blocking the receptors.

According to Nick's talk at the last conference (Nick who wrote that website),

it only takes 8 weeks to get the T4 down enough. They don't understand why it

takes an extra 4 weeks to apparently " clear the receptors " after that.

Cheers,

Mark

> Im pretty sure that its impossible for T3 > RT3 as once its T3 it is the

active hormone, with RT3 being the inactive hormone. So T3 pooling cannont cause

RT3.

>

> Most people need between 75-125mcg of T3 AFTER clearance which is normal and

not supraphysiological for people on T3 only.

>

> The reasoning for it taking 12 weeks to clear RT3, is that you need to get

your T4 low enough so that it cannont convert as much T4 > RT3 so you can clear

the receptors, which according to the RT3 website takes around 12 weeks, and for

me it took around 14 weeks.

>

> Theres alot of info on here if you have time to read it.

[Guest guest]

According to Lowe, the rT3 leaves the body after about 24 hours.

Check out the link I sent yesterday.

Luv - Sheila

See what doesn't make sense to me is, if rT3 does block receptors, then, since

rT3 has the same short half-life as T3 (0.75days), once you suppress rT3 (by

going on T3 only) then the rT3 should be out of the system quickly. But it

usually takes an extra 4 weeks, which to me says rT3 blocking the receptors

can't be the cause....

An alternative is that rT3 is produced due to pooling (caused itself by

cellular resistance). People who need to " clear " rT3 always seem to

need to be on supraphysiological doses of T3 afterwards, which means they must

have cellular resistance not caused by rT3 blocking receptors...

Mark

>

> what's the reasoning behind needing to know?

>

> i think you can get bogged down in all the minutiae of this if you're not

careful (been there, done that)

>

> Dr Lowe talks about resistance a bit here:

>

> http://www.drlowe.com/QandA/askdrlowe/resistnc.htm

[Guest guest]

Hi Mark

Are you taking any L-thyroxine at all, and if so, how much?

If you have had a full iron panel  (serum iron, serum ferritin,

transferrin saturation%, vitamin B12, vitamin D3, folate, magnesium, copper and

zinc done, can you let us have all these results together with the reference

range for each of the tests done - but if not, you need to ask your GP to test

all of these and as soon as possible. Check out the attached document should

your GP try to tell you there is no connection between low levels and low

thyroid.

Are you taking B complex multi-mineral to cope with deficiencies

of trace and macro minerals?

As far as your adrenal profile is concerned, a 24 hour urinary

cortisol test seems appropriate. Can you ask your GP to arrange this?

We'd need heart rate readings, BP (home monitor - if you don't have

one, try Lloyds Pharmacy where you can buy a good one for around £10.00), blood

sugar readings with a monitor, body temperature readings - taken multiple times

during the day. Check out Dr Rind's web site http://www.drrind.com/therapies/metabolic-temperature-graph

I notice also that we do not have a list of all  your symptoms,

and also, what signs are you showing. You can check these against those in our

web site www.tpa-uk.org.uk

under 'Hypothyroidism' and then in the drop down Menu, Symptoms and Signs.

If all looks OK but symptoms show hypothyroid then (AND ONLY

THEN) should you consider pushing the T3 higher. T3 dosages can need to be in

the 100 - 300 mcg range for some people, in order to get past serious cellular

issues. The risks of getting the decision on whether to push on are extreme so

great care is needed. So, an incredibly thorough process would need to take

place first. Ideally a full medical workup would be needed. Pushing on to high

doses of T3 would need a doctors support to evaluate a lot of things first.

High levels of T3 may be the solution BUT I'm not even sure what

the problems are from this.

Hi

Thanks for the article.

Yeah I have checked or am checking the things you mention. I just want to understand

what is causing resistance, is it rT3 or is it something else. I am taking

87.5mcg T3 and I feel nothing, so I must have some massive resistance!

1 of 1 File(s)

LOW MINERALS AND VITAMINS AND THE THYROID CONNECTION.doc

[Guest guest]

Hi Sheila,

Thankyou for taking the time to reply in such detail but I should have

mentioned I am doing this under Dr P's guidance and I am not on any tyroxine. I

have had most of the tests done and am supplementing with all relevant

nutrients. I have also been tracking my temps, BP and pulse for the past 50days

or so and am paying keen attention to any signs of hyper.

Cheers,

Mark

[Guest guest]

Mark

I am not sure if you are using T3, but what i have found with my own experience

is that too much T3 made me worse (same as too much T4).

I assume my body just directed every thing into RT3 if i got on too much. This

was hard for me to work out because obviously everyone is saying you need x

amount of T3 to be well and even more if you have resistance. So i was taking

more and more and not getting anywhere.

I am now pretty balanced and only take 52.5mg T3 per day. This may change as i

am still working out my levels so it could go down even more.

I was on 150 T4 and 50 T3 last yr and when i tried T3 on its own this yr i got

up to 100 and it really didnt work for me.

NB. I have never gotten any hyper signs before and i realise now my body didnt

go down this path. Instead it just made RT3.

I know paul says start using T3 in small amounts and just increase very slowly

and listen to how the body reacts to these increases.

[Guest guest]

Hi,

You've had a bunch of answers - I've not read them all only a few.

What questions do you have left?

>

[Guest guest]

Hi again,

I'd like to re-emphasise Sheila's answers - it is imperative that you check the

basics.

Iron (serum iron, serum ferritin, transferrrin saturation %), B12, folae, vit D

Cortisol via 24 hour urinary cortisol.

Basic things like that can limit the effectiveness of T3.

As can low blood sugar/insulin via a sugar metabolism issue or for instance

through low calorie intake.

Taking too much T3 or too few divided doses can also appear to result in no

further improvement as the dosage rises.

A few more details as Sheila prompted might be useful. Body temp, heart rate and

BP are also essential to track if T3 is being used as normal blood test measures

are unhelpful.

Cheers,

>

>