Dr. uses iodine to fix the rT3/fT3 ratio

[Guest guest]

When testing the thyroid, if both free-T3 and reverse-T3 are tested from the

same blood sample, their ratio is significant.

According to Dr. , when the ratio of reverse-T3 to free-T3

(rT3/fT3) is found to be abnormally high, it indicates the body is in a

condition of " dormancy " , which is metabolically similar to animal hibernation..

This " Human Dormancy Syndrome " (HDS), with an elevated rT3/fT3 ratio, is a

defensive reaction to the presence of a major stress or disease, including, for

example: -- iron deficiency anemia, malnutrition, traumatic injury, toxic

exposure, hidden infection, cancer, or autoimmune disease (e.g. Hashimoto's;

Celiac; Atrophic Gastritis; Pernicious Anemia).

Dr. 's latest patent (i.e. free and open disclosure) includes new

information on this subject:

U.S. Patent 8,075,902 -- http://www.freepatentsonline.com/8075902.pdf

Along with many other subjects covered in this patent, Dr. describes

using iodine to " normalize rT3/fT3 ratio " to a value " below 4.0 " .

A perhaps better-known doctor, Dr. Kent Holtorf uses " T3-only " hormone to

normalize the inverse-ratio (i.e. fT3/rT3) to " above 20 " ... Here, Dr. 's

" rT3/fT3 < 4.0 " is exactly equivalent to the " inverse " ratio of " fT3/rT3 > 25 "

-- (which is a " healthier target " than the lower " > 20 ratio " used by Dr.

Holtorf).

Normalizing this ratio, Dr. writes, can be done using iodine, " such as

Iodoral " .

Some iodine-, thyroid- and rT3 related quotes from the patent: --

.... " Reverse T3/Forward T3 Ratio in Cancer ...... One surprising finding of this

invention is the discovery that patients with cancer have elevated rT3/fT3

ratios. In a group of 14 patients with various cancers, rT3/fT3 ratios were

determined. The results are shown below in Table 3 below. ...... Thus, one

therapeutic goal in these patients is to normalize the rT3/fT3 ratio. This can

be done using a iodine- or iodide-containing composition, such as Iodoral.

However, in patients with thyroxine-sensitive tumors, it can be undesirable to

use T3 itself, because that could increase growth of the tumor. However,

normalization of rT3/fT3 ratio can be produced by increasing production of fT3

by stimulating enzymes responsible for its formation. Because those enzymes are

iodine-dependent, use of iodine- or iodide-containing compositions can be

therapeutically valuable. "

.... " Additional embodiments include use of agents used to treat HDS. For

example, Ursodiol can be used to restore bile volume and improve clearance of

microbial toxins, lipase to digest lipid A from the bile, plaquenil can be used

to block TLR's and restore mitochondrial membrane permeability. Iodine- or

iodide-containing compositions can be used to normalize rT3/fT3 ratio, and

magnesium can be used to maintain metabolic integrity, vitamin C can be used in

doses that are appropriate for the increased oxdative stress associated with

Jarish Herxheimer reactions, and mineral mixtures along with hyperthermia can

enhance cutaneous elimination of toxic antigens. "

.... " Diagnosis of HDS-Related Conditions ...... Measurement of the rT3/fT3

ratio, nitric oxide levels, DHEA-S, free testosterone, estriol, estradiol levels

or other variables denoted in Table 1 are helpful for the purposes of diagnosing

HDS, and numerous clinical and biochemical tests, including diagnostic markers

can be measured and can indicate presence of cancers associated with infections

by Cpn, Mpn, Hpi, HHV and fungi. ... In particular, as disclosed in U.S. Pat.

No. 7,288,257, incorporated herein fully by reference, rT3/fT3 ratio was

measured in a group of 5 normal, athletic, healthy females, selected based upon

general fitness and levels of activity. Serum rT3 and fT3 were measured using

standard methods. The average ratio of rT3 to fT3 was 4.18.+-.1.08 (Standard

Deviation). The standard error of the mean (SEM) was 0.48 (n=5). Finding a

rT3/fT3 ratio greater than about 4 therefore correlates with HDS. "

.... " Use of the natural signals involved in the arousal from hibernation and

dormancy is essential to reversal of HDS and to treat HDS-related conditions.

For example, ascorbic acid levels are elevated in hibernation and especially

during the arousal phase. Treatment of HDS proceeds more rapidly when ascorbic

acid levels are normalized or elevated. Similarly treatment will frequently

benefit from the use of agents that increase fT3 as seen in the arousal stage of

hibernation and lower rT3 levels. Measurement of the rT3/fT3 ratio easily

defines those who will benefit most from normalization of thyroid conversion. "

[Note: LPS = lipopolysaccharide] ... " Our surprising discovery, that the

intracellular LPS-producing pathogen Cpn and other organisms are associated with

immortalizing many if not most or all cancer cells is novel, and we are the

first to demonstrate that anti-Chlamydia pneumoniae (anti-Cpn) treatment

restores apoptosis to cancer cells and can lead to the spontaneous death of

cancer cells. ...... 3.) A low nitric oxide, low ascorbic acid, high oxidative

stress (low GSH/GSSG ratio), high rT3/fT3 ratio, environment favors growth of

LPS producing organisms, such as Cpn. People with Human Dormancy Syndrome have

low nitric oxide levels, partially mediated by an elevated rT3/fT3 ratio as

previously described in U.S. Pat. No. 7,288,257, incorporated herein fully by

reference. ... 4.) Patients with fibromyalgia (FM) have low nitric oxide

secondary to LPS induced Dormancy. Patients with FM have overgrowth of LPS

producing organisms such as Cpn and FM remits with treatment that reverses

Dormancy and eliminates LPS and the infectious organisms which produce LPS. ...

5.) Patients with FM have 50% greater risk of cancer mortality over a 10-year

period than those without chronic pain associated with fibromyalgia (FM). ...

6.) Cpn infection promotes HDS with LPS which influences deiodinase activity,

increasing rT3 levels which slows DNA transcription and metabolism in the same

manner that placenta rT3 maintains dormancy during gestation. ... 7.) Elevated

plasma and tissue levels of reverse T3 and rT3/fT3 ratio is a feature of many

cancers and other Dormancy related conditions. ...... Thus, by eliminating LPS

producing organisms such as Cpn from infected cancer cells, apoptosis can be

restored and spontaneous apoptosis occurs leading to cancer cell death. Because

dormancy favors Cpn growth in many ways and reversing dormancy, for example by

raising body temperature to about 100.degree. F. or more and optimizing rT3/fT3

ratio (e.g., by administering T3), favors the elimination of Cpn. ... Body

temperature for human beings who have triggered HDS and the related disease

states is on average, 97.3 degrees orally, but is often lower, especially during

periods of increased stress. Temperatures as low as 95.4.degree. F. have been

observed in patients with HDS. "

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Note: ... Dr. 's patent writings are general specifications, and do not

include treatment protocols, or clinical results statistics.

Dr. 's office is in Sacramento, California, and his specialty is treating

fibromyalgia and chronic fatigue syndrome.

Very few interviews with Dr. have been published, judging by a Google

search.. Someone should contact his office for an interview...

Bill

____________

Reference:

J. , D.O.

Fellowship, Stanford Division of Immunology & Rheumatology

Board Certified in Internal Medicine and Rheumatology

Fibromyalgia Treatment & Learning Center

http://www.fmtlc.com/contact.html

650 University Avenue, Suite 200

Sacramento, CA 95825

Phone: 916-922-8400 Fax: 916-922-8488

Our treatment approach

http://www.fmtlc.com/treatment.html

Dr. 's Bio

http://www.fmtlc.com/bio.html

--- Dr. 's " Human Dormancy Syndrome " patents:

8,075,902 - 2011-12-13

http://www.freepatentsonline.com/8075902.pdf

7,648,704 - 2010-01-19

http://www.freepatentsonline.com/7648704.pdf

7,485,298 - 2009-02-03

http://www.freepatentsonline.com/7485298.pdf

7,288,257 - 2007-10-30

http://www.freepatentsonline.com/7288257.pdf

...