Unusual Manifestations of Hypothyroidism

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Unusual Manifestations of Hypothyroidism

http://archinte.ama-assn.org/cgi/reprint/144/1/123.pdf?ijkey=aa99568f984bb7a72337b45fee22d9249e744fe5

Irwin Klein, MD, Gerald S. Levey, MD

Thyroid hormone exerts direct effects on essentially

all of

the organ systems of the body. Hypothyroidism

is a frequently

diagnosed endocrine disorder that has

characteristic clinical

signs and symptoms. In addition to these common

manifestations,

however, there are many additional manifestations

of

hypothyroidism that are less commonly acknowledged

and

Include involvement of the hematologic, muscular,

cardiac,

and rheumatologic systems. It is important to

recognize that

these other organ systems may be involved and

that the

resulting disease states can dominate the

clinical picture. As

with the classic manifestations of hypothyroidism,

these unusual

manifestations respond to thyroid hormone replacement

therapy. Thus, the importance of recognizing these

signs

and symptoms, as a result of hypothyroidism, is

evident. This

article emphasizes these less common manifestations

of the

patient with hypothyroidism, and, in addition,

discusses the

possible pathophysiologic mechanisms by which

thyroid hormone

deficiency can lead to organ system

dysfunction.

(Arch

Intern Med 1984;144:123-128)