Guest guest Posted January 30, 2012 Report Share Posted January 30, 2012 The online clinic closed at 5.29pm, they just couldn't wait could they? I just had time to see you had replied to " Thyroxine doesn't work " but when I tried to look the thing closed!! Hope you can remember what you said. I had posted my results as they were before I self medicated with T3 just to see the 'experts' answer. Your response followed Beasties answer(below)which I cannot translate. There was no intercurrent illness - I was hypothyroid and they tested me for everything else under the sun. Thanks Re: Thyroxine does not work by Dr Graham Beastall on Mon Jan 30, 2012 6:00 pm I am happy to pick up this chain of messages. The reality is that thyroxine does work for hundreds of thousands of people in the UK. If it works for them then of course, they are happy and they do not complain. There are a small number of people for whom the optimisation of thyroxine replacement proves challenging. The aim of thyroxine replacement is to alleviate symptoms and, ideally, to restore the serum TSH result to the reference range. However, it is recognised that some patients have better symptom relief if the TSH is at or slightly below the lower end of the reference range. On the face of it Sazzia is slightly under-replaced with thyroxine because her TSH is just above the upper limit of the reference range. However, she has complicating clinical features that mean that increasing the thyroxine dose may not be wise. Failure to convert T4 into biologically active T3 is an extremely rare primary condition. On the other hand it is a very common natural defence mechanism for the body to control the conversion of T4 into T3 when there is intercurrent illness of a non-thyroidal nature. Overcoming this natural defence mechanism by giving T3 may not be wise and it is better, if possible, to treat the intercurrent condition. Dr Graham Beastall President of the International Federation of Clinical Chemistry and Laboratory Medicine Quote Link to comment Share on other sites More sharing options...
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