RE: Re: HELP NEEDED T4 with T3

[Guest guest]

Hi

You first really need to find the reason why you are not feeling

great on T3-only hormone. Read about the associated conditions that go along

with being hypothyroid and that stop thyroid hormone from being properly

utilised at the cellular level.

There are MANY reasons and many medical conditions associated

with thyroid disease that stop thyroid hormone from getting into the cells,

where it does its work. I mention these over and over and over again - ad

nauseum - people must be bored with the same old stuff, but as each new member

joins us, they need to know about these.

The main condition responsible for stopping thyroid hormone from

working is, quite simply, a patient’s thyroid hormone dose is too low because

the doctor or consultant refuses to increase it, because the serum thyroid

function test results appear OK. Sometimes, the thyroxine dose is too high, yet

patients still don't feel well. They continue to suffer. Some reasons

for this:

1. You may be suffering with low adrenal

reserve. The production of T4, its conversion to T3, and the receptor uptake

requires a normal amount of adrenal hormones, notably, of course, cortisone.

(Excess cortisone can shut production down, however.) This is what happens if

the adrenals are not responding properly, and provision of cortisone usually

switches it on again. But sometimes it doesn’t. If the illness has

been going on for a long time, the enzyme seems to fail. This conversion

failure (inexplicably denied by many endocrinologists) means the thyroxine

builds up, unconverted. So it doesn’t work, and T4 toxicosis results.

This makes the patient feel quite unwell, toxic, often with palpitations and

chest pain. If provision of adrenal support doesn’t remedy the situation, the

final solution is the use of the active thyroid hormone, already converted, T3

- either synthetic or natural. You can check for such a possibility by going to

the FILES SECTION of our forum http://health.grouops//thyroid treatment/files/

and scroll down to the folder entitled 'Medical Questionnaires' and complete the

Adrenal one. Let us know how you score. You can also get the 24 hour salivary

adrenal profile from Genova Diagnostics. See the File entitled 'Discounts on

Tests and Supplements'. When ordering, write that Thyroid Patient Advocacy is

your medical practitioner. They will send out a kit to you and the results will

be sent direct to you. When you receive these, post the results on the forum

with the reference ranges and we will help with their interpretation.

2. Then, we have systemic candidiasis. This is

where candida albicans, yeast, which causes skin infections almost anywhere in

the body, invades the lining of the lower part of the small intestine and the

large intestine. Here, the candida sets up residence in the warmth and

the dark, and demands to be fed. Loving sugars and starches, candida can

make you suffer terrible sweet cravings. Candida can produce toxins which

can cause very many symptoms of exhaustion, headache, general illness, and

which interfere with the uptake of thyroid and adrenal treatment.

Sometimes the levels - which we usually test for - can be very high, and make

successful treatment difficult to achieve until adequately treated. As above,

do the 'Candida Questionnaire' and let us know how you score, and again, you

can be tested by Genova Diagnostics to give you diagnosis.

3. Then there is receptor resistance which

could be a culprit. Being hypothyroid for some considerable time may

mean the biochemical mechanisms which permit the binding of T3 to the

receptors, is downgraded - so the T3 won’t go in. With slow build up of

T3, with full adrenal support and adequate vitamins and minerals, the receptors

do come on line again. But this can be quite a slow process, and care has

to be taken to build the dose up gradually.

4. And then there are Food allergies. The most

common food allergy is allergy to gluten, the protein fraction of wheat. The

antibody generated by the body, by a process of molecular mimicry, cross reacts

with the thyroperoxidase enzyme, (which makes thyroxine) and shuts it

down. So allergy to bread can make you hypothyroid. There may be other

food allergies with this kind of effect, but information on these is

scanty. Certainly allergic response to certain foods can affect adrenal

function and imperil thyroid production and uptake.

5. Then we have hormone imbalances. The whole

of the endocrine system is linked; each part of it needs the other parts to be

operating normally to work properly. An example of this we have seen

already, with cortisone. But another example is the operation of sex

hormones. The imbalance that occurs at the menopause with progesterone

running down, and a relative dominance of oestrogen is a further case in point

– oestrogen dominance downgrades production, transportation and uptake of

thyroid hormones. This is why hypothyroidism may first appear at the

menopause; the symptoms ascribed to this alone, which is then treated – often

with extra oestrogen, making the whole thing worse. Deficiency in

progesterone most especially needs to be dealt with, since it reverses

oestrogen dominance, improves many menopausal symptoms like sweats and mood

swings, and reverses osteoporosis. Happily natural progesterone cream is

easily obtained: when used it has the added benefit of helping to stabilise

adrenal function.

6. Then, there is the possibility of mercury

poisoning, caused through amalgam fillings - these might need to be removed but

you need to seek a Dentist who specialises in the removal of amalgam fillings.

7. One of the main reasons why thyroid hormone

is not being utilised at the cellular level is because you might be suffering

with low levels of iron, transferring saturation%, ferritin, vitamin B12,

vitamin D3, magnesium, folate, copper and zinc - these have to be tested

for, and treated.

When you have been quite unwell for a long time, all these

problems have to be dealt with, and since each may affect the other, it all has

to be done very carefully.

Ask your doctor to work with you to help you find the cause. The

balancing of these variables is as much up to you as to your doctor – which is

why a check of morning, day and evening temperatures and pulse rates, together

with symptoms, good and bad, can be so helpful. To this end, check out Dr

Rind's Metabolic Metabolic Temperature Graph http://www.drrind.com/therapies/metabolic-temperature-graph

If your doctor tries to tell you that low levels of the above

mentioned nutrients have nothing to do with your low thyroid state, copy out

the following of just a few references to the research/studies that have been

done to show that there is a very big connection. Doctors are not taught about

this at medical school, so we have to help them where we can - so they, in

turn, can help their other patients.

Low iron/ferritin: Iron deficiency is shown to significantly

reduce T4 to T3 conversion, increase reverse T3 levels, and block the

thermogenic (metabolism boosting) properties of thyroid hormone (1-4). Thus,

iron deficiency, as indicated by an iron saturation below 25 or a ferritin

below 70, will result in diminished intracellular T3 levels. Additionally, T4

should not be considered adequate thyroid replacement if iron deficiency is

present (1-4)).

1. Dillman E, Gale C, Green W, et al.

Hypothermia in iron deficiency due to altered triiodithyroidine metabolism.

Regulatory, Integrative and Comparative Physiology 1980;239(5):377-R381.

2. SM, PE, Lukaski HC. In vitro

hepatic thyroid hormone deiodination in iron-deficient rats: effect of dietary

fat. Life Sci 1993;53(8):603-9.

3. Zimmermann MB, Köhrle J. The Impact of Iron

and Selenium Deficiencies on Iodine and Thyroid Metabolism: Biochemistry and

Relevance to Public Health. Thyroid 2002;12(10): 867-78.

4. Beard J, tobin B, Green W. Evidence for

Thyroid Hormone Deficiency in Iron-Deficient Anemic Rats. J. Nutr.

1989;119:772-778.

Low vitamin B12: http://www.ncbi.nlm.nih.gov/pubmed/18655403

Low vitamin D3: http://www.eje-online.org/cgi/content/abstract/113/3/329

and http://www.goodhormonehealth.com/VitaminD.pdf

Low magnesium: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC292768/pdf/jcinvest00264-0105.pdf

Low folate: http://www.clinchem.org/cgi/content/full/47/9/1738

and http://www.liebertonline.com/doi/abs/10.1089/thy.1999.9.1163

Low copper http://www.ithyroid.com/copper.htm

http://www.drlwilson.com/articles/copper_toxicity_syndrome.htm

http://www.ithyroid.com/copper.htm

http://www.rjpbcs.com/pdf/2011_2(2)/68.pdf

http://ajplegacy.physiology.org/content/171/3/652.extract

Low zinc:http://www.istanbul.edu.tr/ffdbiyo/current4/07%20Iham%20AM%C4%B0R.pdf

and http://articles.webraydian.com/article1648-Role_of_Zinc_and_Copper_in_Effective_Thyroid_Function.html

· NOTE: When

your blood tests come back, ask your doctor for a copy and remember to always

get the reference range and post them on the forum. This is because doctors

will often tell you that there is not a problem because blood tests have come

back within the reference range. You need to know where about in the reference

range they are. We will again, help with their interpretation.

Could I

please ask the opinion of people who have experience of this: I am not feeling

great on T3 only, although only in the early stages. Is there anyone taking the

synthetic form of T4 along with T3? How did you manage your dosing? I would

really appreciate the help of anyone who is doing well on both T4 and T3.

Thanks in

advance.

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WHY THYROID HORMONE REPLACEMENT MAY NOT BE WORKING FOR YOU.doc