Guest guest Posted March 10, 2012 Report Share Posted March 10, 2012 It sounds as if you could be suffering with one of the many associated conditions that go along with symptoms of hypothyroidism and you should go through each one of these to check (through a process of elimination) that one (or more) of these is not the cause for not being able to increase your dose. First, if you are getting palpitations when increasing your dose of T3, take 500mgs Magnesium Citrate and this should help ease them. If you are suffering with any of these conditions, no amount of thyroid hormone can be properly utilised at the cellular level until whatever you are suffering has been treated. 1. You may be suffering with low adrenal reserve. The production of T4, its conversion to T3, and the receptor uptake requires a normal amount of adrenal hormones, notably, of course, cortisone. (Excess cortisone can shut production down, however.) This is what happens if the adrenals are not responding properly, and provision of cortisone usually switches it on again. But sometimes it doesn’t. If the illness has been going on for a long time, the enzyme seems to fail. This conversion failure (inexplicably denied by many endocrinologists) means the thyroxine builds up, unconverted. So it doesn’t work, and T4 toxicosis results. This makes the patient feel quite unwell, toxic, often with palpitations and chest pain. If provision of adrenal support doesn’t remedy the situation, the final solution is the use of the active thyroid hormone, already converted, T3 - either synthetic or natural. You can check for such a possibility by going to the FILES SECTION of our forum http://health.grouops//thyroid treatment/files/ and scroll down to the folder entitled 'Medical Questionnaires' and complete the Adrenal one. Let us know how you score. You can also get the 24 hour salivary adrenal profile from Genova Diagnostics. See the File entitled 'Discounts on Tests and Supplements'. When ordering, write that Thyroid Patient Advocacy is your medical practitioner. They will send out a kit to you and the results will be sent direct to you. When you receive these, post the results on the forum with the reference ranges and we will help with their interpretation. 2. Then, we have systemic candidiasis. This is where candida albicans, yeast, which causes skin infections almost anywhere in the body, invades the lining of the lower part of the small intestine and the large intestine. Here, the candida sets up residence in the warmth and the dark, and demands to be fed. Loving sugars and starches, candida can make you suffer terrible sweet cravings. Candida can produce toxins which can cause very many symptoms of exhaustion, headache, general illness, and which interfere with the uptake of thyroid and adrenal treatment. Sometimes the levels - which we usually test for - can be very high, and make successful treatment difficult to achieve until adequately treated. As above, do the 'Candida Questionnaire' and let us know how you score, and again, you can be tested by Genova Diagnostics to give you diagnosis. 3. Then there is receptor resistance which could be a culprit. Being hypothyroid for some considerable time may mean the biochemical mechanisms which permit the binding of T3 to the receptors, is downgraded - so the T3 won’t go in. With slow build up of T3, with full adrenal support and adequate vitamins and minerals, the receptors do come on line again. But this can be quite a slow process, and care has to be taken to build the dose up gradually. 4. And then there are Food allergies. The most common food allergy is allergy to gluten, the protein fraction of wheat. The antibody generated by the body, by a process of molecular mimicry, cross reacts with the thyroperoxidase enzyme, (which makes thyroxine) and shuts it down. So allergy to bread can make you hypothyroid. There may be other food allergies with this kind of effect, but information on these is scanty. Certainly allergic response to certain foods can affect adrenal function and imperil thyroid production and uptake. 5. Then we have hormone imbalances. The whole of the endocrine system is linked; each part of it needs the other parts to be operating normally to work properly. An example of this we have seen already, with cortisone. But another example is the operation of sex hormones. The imbalance that occurs at the menopause with progesterone running down, and a relative dominance of oestrogen is a further case in point – oestrogen dominance downgrades production, transportation and uptake of thyroid hormones. This is why hypothyroidism may first appear at the menopause; the symptoms ascribed to this alone, which is then treated – often with extra oestrogen, making the whole thing worse. Deficiency in progesterone most especially needs to be dealt with, since it reverses oestrogen dominance, improves many menopausal symptoms like sweats and mood swings, and reverses osteoporosis. Happily natural progesterone cream is easily obtained: when used it has the added benefit of helping to stabilise adrenal function. 6. Then, there is the possibility of mercury poisoning, caused through amalgam fillings - these might need to be removed but you need to seek a Dentist who specialises in the removal of amalgam fillings. 7. One of the main reasons why thyroid hormone is not being utilised at the cellular level is because you might be suffering with low levels of iron, transferring saturation%, ferritin, vitamin B12, vitamin D3, magnesium, folate, copper and zinc - these have to be tested for, and treated. When you have been quite unwell for a long time, all these problems have to be dealt with, and since each may affect the other, it all has to be done very carefully. Ask your doctor to work with you to help you find the cause. The balancing of these variables is as much up to you as to your doctor – which is why a check of morning, day and evening temperatures and pulse rates, together with symptoms, good and bad, can be so helpful. To this end, check out Dr Rind's Metabolic Metabolic Temperature Graph http://www.drrind.com/therapies/metabolic-temperature-graph If your doctor tries to tell you that low levels of the above mentioned nutrients have nothing to do with your low thyroid state, copy out the following of just a few references to the research/studies that have been done to show that there is a very big connection. Doctors are not taught about this at medical school, so we have to help them where we can - so they, in turn, can help their other patients. Low iron/ferritin: Iron deficiency is shown to significantly reduce T4 to T3 conversion, increase reverse T3 levels, and block the thermogenic (metabolism boosting) properties of thyroid hormone (1-4). Thus, iron deficiency, as indicated by an iron saturation below 25 or a ferritin below 70, will result in diminished intracellular T3 levels. Additionally, T4 should not be considered adequate thyroid replacement if iron deficiency is present (1-4)). 1. Dillman E, Gale C, Green W, et al. Hypothermia in iron deficiency due to altered triiodithyroidine metabolism. Regulatory, Integrative and Comparative Physiology 1980;239(5):377-R381. 2. SM, PE, Lukaski HC. In vitro hepatic thyroid hormone deiodination in iron-deficient rats: effect of dietary fat. Life Sci 1993;53(8):603-9. 3. Zimmermann MB, Köhrle J. The Impact of Iron and Selenium Deficiencies on Iodine and Thyroid Metabolism: Biochemistry and Relevance to Public Health. Thyroid 2002;12(10): 867-78. 4. Beard J, tobin B, Green W. Evidence for Thyroid Hormone Deficiency in Iron-Deficient Anemic Rats. J. Nutr. 1989;119:772-778. Low vitamin B12: http://www.ncbi.nlm.nih.gov/pubmed/18655403 Low vitamin D3: http://www.eje-online.org/cgi/content/abstract/113/3/329 and http://www.goodhormonehealth.com/VitaminD.pdf Low magnesium: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC292768/pdf/jcinvest00264-0105.pdf Low folate: http://www.clinchem.org/cgi/content/full/47/9/1738 and http://www.liebertonline.com/doi/abs/10.1089/thy.1999.9.1163 Low copper http://www.ithyroid.com/copper.htm http://www.drlwilson.com/articles/copper_toxicity_syndrome.htm http://www.ithyroid.com/copper.htm http://www.rjpbcs.com/pdf/2011_2(2)/68.pdf http://ajplegacy.physiology.org/content/171/3/652.extract Low zinc:http://www.istanbul.edu.tr/ffdbiyo/current4/07%20Iham%20AM%C4%B0R.pdf and http://articles.webraydian.com/article1648-Role_of_Zinc_and_Copper_in_Effective_Thyroid_Function.html · NOTE: When your blood tests come back, ask your doctor for a copy and remember to always get the reference range and post them on the forum. This is because doctors will often tell you that there is not a problem because blood tests have come back within the reference range. You need to know where about in the reference range they are. We will again, help with their Luv - Sheila Blood pressure has come back down to 115/67 but heart rate still 80ish which I know is ok but normal for me is I think about 70 and it's not budged all day. When I was hypo and increasing my dose it was usually 60ish. Still getting slightly raised heart rate, palpitations and skipped beats, mostly when I get up to do something which triggers it. Also may have had GI symptoms - not quite diarrohea (sorry) but not normal. How long until the T3 leaves my system? I would have thought it would be gone by now? But my body's not settled back down yet. But... I'm now getting new chest pains which I think are similar to the ones I got when I lowered my dose previously and they were hypo symptoms which seemed to go with a dose increase (sorry, 3 types of chest pains here - it's getting complicated so understand if I've lost you :-) ) Just don't really know what to do really. xx > > Hi, > > How much have you been taking? Have you lowered your dose of T4 (if you were on it....) > > What signs of being hyper do you have? > > sorry, a bit more info would help..... It's quite hard to go hyper just from a slightly increased dose of T3...... despite what the scare stories tell you...... > > x > No virus found in this message. Checked by AVG - www.avg.com Version: 2012.0.1913 / Virus Database: 2114/4860 - Release Date: 03/09/12 Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 11, 2012 Report Share Posted March 11, 2012 Grasp the nettle and face it that your problem just might be heart related with the symptoms you are getting, and it could be that you are suffering with Angina. If this happens again, telephone NHS direct or try to speak to your GP. He will want you to either go to the surgery or to your local hospital for an ECG as they need to do this during such an episode of pain in your chest with pain going down left arm and into your neck. It might help meanwhile to take an aspirin and take magnesium, if you get any more palpitations to see if that helps, but you must get an ECG and not put this off. I may well be wrong, but it is better to be safe than sorry. You might be experiencing an early warning. I doubt the T3 at such a tiny dose would cause the symptoms you are feeling. Read the following information http://www.bupa.co.uk/individuals/health-information/directory/a/angina Luv - Sheila Hello, please could someone help me with my below problem? I don't know what to do. > > I was feeling a bit better today as hadn't taken any t3 since yesterday afternoon (2.5mcg all day). This morning my pulse was down somewhere in the 70s and was getting fewer skipped beats and by the afternoon I thought this had gone. I started to feel really tired and was getting head rushes so decided I needed another dose. I took 2.5mcg and this got rid of the head rushes and I felt less tired but it gave me palpitations a couple of hours after. > > This wore off, then tonight I stupidly had half a glass of wine and started getting palpitations, stabbing pains and my chest and an ache down my left arm and up into my neck. This seems to be going now but I'm really confused as to what's going on. > > I don't think I'm going to touch any more for a while and certainly no alcohol. > > Does anyone have any idea what's going on?!?!?! Would appreciate any advice. > > Thanks xx Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 13, 2012 Report Share Posted March 13, 2012 Where did you get the T3? I tried some once from a body building site and got terrible reactions, I think there was a lot of other rubbish in it.Just a thought. Caroline Hi, please could someone help me? I'm so confused by this. Thanks a lot xx---------------------------------------------I think I can therefore conclude that it's the t3 which has upset my system abit? The capsules I'm taking are unlicensed as they're only 2.5mcg so I wonderif maybe that's something to do with it? Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 13, 2012 Report Share Posted March 13, 2012 This is exactly why we have a document in our files section - thyroid treatment/files/ that shows the reputable Internet Pharmacies where you can buy such medicines safely. Open the folder entitled 'Discounts on Tests and Supplements' and you will find all the information you need there. Luv - Sheila Where did you get the T3? I tried some once from a body building site and got terrible reactions, I think there was a lot of other rubbish in it. Just a thought. Caroline Hi, please could someone help me? I'm so confused by this. Thanks a lot xx --------------------------------------------- I think I can therefore conclude that it's the t3 which has upset my system a bit? The capsules I'm taking are unlicensed as they're only 2.5mcg so I wonder if maybe that's something to do with it? No virus found in this message. Checked by AVG - www.avg.com Version: 2012.0.1913 / Virus Database: 2114/4867 - Release Date: 03/12/12 Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 16, 2012 Report Share Posted March 16, 2012 We're trying to help, but you also need to help yourself too. I did post the other day a list of the many associated conditions that go along with being hypothyroid that you should check for, but you just wrote back to say you didn't believe any of these were anything to do with you….but you really should go through each one by way of a process of elimination. Especially, you should ask your GP if he will check your levels of iron, transferrin saturation%, ferritin, vitamin B12, vitamin D3, magnesium, folate, copper and zinc. Don't just assume that he will not do these tests. Doctors are there to help find the cause of your symptoms. Your raised CRP could be because you have some 'hidden' infection that you don't know about. Have you considered, for instance, that you might be suffering with systemic candidiasis, and this would cause your CRP to be raised. Check http://www.webmd.com/a-to-z-guides/c-reactive-protein-crp .. Luv - Sheila Hi, please could someone help me? I'm so confused by this. Thanks a lot xx --------------------------------------------- Thanks for your message and the link. This is certainly a possibility I have been considering. I ended up going to A & E last night just to be sure and get checked out. 3 ECGs were fine and the troponin blood test was negative so they said I could go. So my heart hadn't been damaged. CRP was 10 (top of the range was 7) but noone seemed bothered by this. I am in my 20s and am a normal BMI. Normal blood pressure and heart rate. Quote Link to comment Share on other sites More sharing options...
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