Current approaches and future possibilities. Primary Hypothyroidism

[Guest guest]

Source: Drug Des Devel Ther |

Posted 1 week ago

Treatment

for primary hypothyroidism: current approaches and future possibilities; Chakera AJ, Pearce SH, Vaidya B; Drug Design, Development

and Therapy 6 1-11 (2012)

Primary

hypothyroidism is the most common endocrine disease. Although the diagnosis and

treatment of hypothyroidism is often considered simple, there are large numbers

of people with this condition who are suboptimally treated. Even in those

people with hypothyroidism who are biochemically euthyroid on levothyroxine

replacement there is a significant proportion who report poorer quality of

life. This review explores the historical and current treatment options for

hypothyroidism, reasons for and potential solutions to suboptimal treatment,

and future possibilities in the treatment of hypothyroidism.

http://www.docguide.com/treatment-primary-hypothyroidism-current-approaches-and-future-possibilities?tsid=6#comments

[Guest guest]

Hi Sheila -I can't get in to the article - Is there another link ? Thanks

>

>

> Source: <http://www.docguide.com/journals/drug-des-devel-ther?tsid=6> Drug

> Des Devel Ther | Posted 1 week ago

[Guest guest]

, apparently you have to register, but I would highly

recommend it as they have all the up to date information on research, studies

etc. Here is the link to register http://www.docguide.com/colleagues/invite?tsid=1

Hope it works.

Luv - Sheila

Hi Sheila -I can't get in to the article - Is

there another link ? Thanks

>

>

> Source: <http://www.docguide.com/journals/drug-des-devel-ther?tsid=6>

Drug

> Des Devel Ther | Posted 1 week ago

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Version: 2012.0.1913 / Virus Database: 2114/4858 - Release Date: 03/08/12

[Guest guest]

HI SHEILA

I have just joined up with this site and it is quite interesting.

Kathleen

> >

> >

> > Source: <http://www.docguide.com/journals/drug-des-devel-ther?tsid=6> Drug

> > Des Devel Ther | Posted 1 week ago

>

>

>

> _____

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> No virus found in this message.

> Checked by AVG - www.avg.com

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[Guest guest]

Hi Sheila -found it on PUBMED -PMID22291465 -the whole article is available . I

do so like their statement that-- " levo thyroxine is the treatment of choice "

Who exactly has this choice ? Maybe they need a copy of " Shared Decision Making

" ?

[Guest guest]

Doesn't work for me .

Luv - Sheila

Hi Sheila -found it on PUBMED -PMID22291465

-the whole article is available . I do so like their statement that-- " levo

thyroxine is the treatment of choice " Who exactly has this choice ? Maybe

they need a copy of " Shared Decision Making " ?

No

virus found in this message.

Checked by AVG - www.avg.com

Version: 2012.0.1913 / Virus Database: 2114/4859 - Release Date: 03/08/12

[Guest guest]

Hi Sheila -google PMID22291465 -the article is under Chakera {PUBMED] .For the

full article the link at the top is either Dove PRESS or PUBMED hope this works

this time

[Guest guest]

Thanks - it worked this time.

Luv - Sheila

Hi Sheila -google PMID22291465 -the article is

under Chakera {PUBMED] .For the full article the link at the top is either Dove

PRESS or PUBMED hope this works this time

No

virus found in this message.

Checked by AVG - www.avg.com

Version: 2012.0.1913 / Virus Database: 2114/4861 - Release Date: 03/09/12

[Guest guest]

Glad you could find it Sheila -its not to hard to read and contains one or two

interesting items

1. " it has been shown that the variation within TSH within an individual is

narrower than the variation in the general population ,supporting the concept of

an INDIVIDUAL REFERENCE RANGE ,such that a TSH level within the POPULATION

REFERENCE RANGE may still be ABNORMAL for that individual !!!!!!!!

2.Interestingly,patients in two trials reported a PREFERENCE for combination

therapy despite no objective improvement in wellbeing ??????? [what about

improvement in remaining symptoms ??}

3. A recent meta analysis for over 55,000 subjects ,from ELEVEN studies showed

that SUBCLINICAL hypothyroidism is associated with an INCREASED RISK of

CARDIOVASCULAR EVENTS and MORTALITY ,particularly if TSH is 10mIU/L or OVER

{GP's should know this }

There is probably more but tea is ready