RE: That 'lights switched on' feeling

[Guest guest]

Hi Annie -

yes, indeedy - it is VERY possible to get well and remain well once you have

everything in place. First, take a look through this list and go through each

of these possibilities by way of a process of elimination. There are MANY reasons and many

medical conditions associated with thyroid disease that stop thyroid hormone

from getting into the cells, where it does its work. I mention these over and

over and over again - ad nauseum - people must be bored with the same old

stuff, but as each new member joins us, they need to know about these.

The main

condition responsible for stopping thyroid hormone from working is, quite

simply, a patient’s thyroid hormone dose is too low because the doctor or

consultant refuses to increase it, because the serum thyroid function test

results appear OK. Sometimes, the thyroxine dose is too high, yet patients

still don't feel well. They continue to suffer. Some reasons for this:

1.

You may be suffering with low adrenal reserve. The production of T4, its

conversion to T3, and the receptor uptake requires a normal amount of adrenal

hormones, notably, of course, cortisone. (Excess cortisone can shut production

down, however.) This is what happens if the adrenals are not responding

properly, and provision of cortisone usually switches it on again. But

sometimes it doesn’t. If the illness has been going on for a long

time, the enzyme seems to fail. This conversion failure (inexplicably

denied by many endocrinologists) means the thyroxine builds up,

unconverted. So it doesn’t work, and T4 toxicosis results. This

makes the patient feel quite unwell, toxic, often with palpitations and chest

pain. If provision of adrenal support doesn’t remedy the situation, the

final solution is the use of the active thyroid hormone, already converted, T3

- either synthetic or natural. You can check for such a possibility by going to

the FILES SECTION of our forum http://health.grouops//thyroid treatment/files/

and scroll down to the folder entitled 'Medical Questionnaires' and complete

the Adrenal one. Let us know how you score. You can also get the 24 hour

salivary adrenal profile from Genova Diagnostics. See the File entitled

'Discounts on Tests and Supplements'. When ordering, write that Thyroid Patient

Advocacy is your medical practitioner. They will send out a kit to you and the

results will be sent direct to you. When you receive these, post the results on

the forum with the reference ranges and we will help with their interpretation.

2.

Then, we have systemic candidiasis. This is where candida albicans, yeast,

which causes skin infections almost anywhere in the body, invades the lining of

the lower part of the small intestine and the large intestine. Here, the

candida sets up residence in the warmth and the dark, and demands to be

fed. Loving sugars and starches, candida can make you suffer terrible

sweet cravings. Candida can produce toxins which can cause very many

symptoms of exhaustion, headache, general illness, and which interfere with the

uptake of thyroid and adrenal treatment. Sometimes the levels - which we

usually test for - can be very high, and make successful treatment difficult to

achieve until adequately treated. As above, do the 'Candida Questionnaire' and

let us know how you score, and again, you can be tested by Genova Diagnostics

to give you diagnosis.

3.

Then there is receptor resistance which could be a culprit. Being hypothyroid

for some considerable time may mean the biochemical mechanisms which permit the

binding of T3 to the receptors, is downgraded - so the T3 won’t go

in. With slow build up of T3, with full adrenal support and adequate

vitamins and minerals, the receptors do come on line again. But this can

be quite a slow process, and care has to be taken to build the dose up

gradually.

4.

And then there are Food allergies. The most common food allergy is allergy to

gluten, the protein fraction of wheat. The antibody generated by the body, by a

process of molecular mimicry, cross reacts with the thyroperoxidase enzyme,

(which makes thyroxine) and shuts it down. So allergy to bread can make

you hypothyroid. There may be other food allergies with this kind of effect,

but information on these is scanty. Certainly allergic response to

certain foods can affect adrenal function and imperil thyroid production and

uptake.

5.

Then we have hormone imbalances. The whole of the endocrine system is linked;

each part of it needs the other parts to be operating normally to work

properly. An example of this we have seen already, with cortisone.

But another example is the operation of sex hormones. The imbalance that

occurs at the menopause with progesterone running down, and a relative

dominance of oestrogen is a further case in point – oestrogen dominance

downgrades production, transportation and uptake of thyroid hormones.

This is why hypothyroidism may first appear at the menopause; the symptoms

ascribed to this alone, which is then treated – often with extra

oestrogen, making the whole thing worse. Deficiency in progesterone most

especially needs to be dealt with, since it reverses oestrogen dominance,

improves many menopausal symptoms like sweats and mood swings, and reverses

osteoporosis. Happily natural progesterone cream is easily obtained: when

used it has the added benefit of helping to stabilise adrenal function.

6.

Then, there is the possibility of mercury poisoning, caused through amalgam

fillings - these might need to be removed but you need to seek a Dentist who

specialises in the removal of amalgam fillings.

7.

One of the main reasons why thyroid hormone is not being utilised at the cellular

level is because you might be suffering with low levels of iron, transferring

saturation%, ferritin, vitamin B12, vitamin D3, magnesium, folate, copper and

zinc - these have to be tested for, and treated.

When you

have been quite unwell for a long time, all these problems have to be dealt

with, and since each may affect the other, it all has to be done very

carefully.

Ask your

doctor to work with you to help you find the cause. The balancing of these

variables is as much up to you as to your doctor – which is why a check

of morning, day and evening temperatures and pulse rates, together with

symptoms, good and bad, can be so helpful. To this end, check out Dr Rind's

Metabolic Metabolic Temperature Graph http://www.drrind.com/therapies/metabolic-temperature-graph

If your

doctor tries to tell you that low levels of the above mentioned nutrients have

nothing to do with your low thyroid state, copy out the following of just a few

references to the research/studies that have been done to show that there is a

very big connection. Doctors are not taught about this at medical school, so we

have to help them where we can - so they, in turn, can help their other

patients.

Low iron/ferritin:

Iron deficiency is shown to significantly reduce T4 to T3 conversion, increase

reverse T3 levels, and block the thermogenic (metabolism boosting) properties

of thyroid hormone (1-4). Thus, iron deficiency, as indicated by an iron

saturation below 25 or a ferritin below 70, will result in diminished

intracellular T3 levels. Additionally, T4 should not be considered adequate

thyroid replacement if iron deficiency is present (1-4)). 1.

Dillman E, Gale C, Green W, et al. Hypothermia in iron deficiency due to

altered triiodithyroidine metabolism. Regulatory, Integrative and Comparative

Physiology 1980;239(5):377-R381.

2.

SM, PE, Lukaski HC. In vitro hepatic thyroid hormone deiodination

in iron-deficient rats: effect of dietary fat. Life Sci 1993;53(8):603-9.

3.

Zimmermann MB, Köhrle J. The Impact of Iron and Selenium Deficiencies on Iodine

and Thyroid Metabolism: Biochemistry and Relevance to Public Health. Thyroid

2002;12(10): 867-78.

4.

Beard J, tobin B, Green W. Evidence for Thyroid Hormone Deficiency in

Iron-Deficient Anemic Rats. J. Nutr. 1989;119:772-778.Low vitamin B12: http://www.ncbi.nlm.nih.gov/pubmed/18655403

Low vitamin

D3: http://www.eje-online.org/cgi/content/abstract/113/3/329

and http://www.goodhormonehealth.com/VitaminD.pdf

Low

magnesium: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC292768/pdf/jcinvest00264-0105.pdf

Low folate:

http://www.clinchem.org/cgi/content/full/47/9/1738

and http://www.liebertonline.com/doi/abs/10.1089/thy.1999.9.1163

Low

copper http://www.ithyroid.com/copper.htm

http://www.drlwilson.com/articles/copper_toxicity_syndrome.htm

http://www.ithyroid.com/copper.htm

http://www.rjpbcs.com/pdf/2011_2(2)/68.pdf

http://ajplegacy.physiology.org/content/171/3/652.extract

Low zinc:http://www.istanbul.edu.tr/ffdbiyo/current4/07%20Iham%20AM%C4%B0R.pdf

and http://articles.webraydian.com/article1648-Role_of_Zinc_and_Copper_in_Effective_Thyroid_Function.html

NOTE: When your blood tests come back, ask your doctor for a copy and remember

to always get the reference range and post them on the forum. This is because

doctors will often tell you that there is not a problem because blood tests

have come back within the reference range. You need to know where about in the

reference range they are. We will again, help with their interpretation.

Luv -

Sheila

When I commenced Nature Throid medication last year I experienced the wonderful

feeling of optimal health, I had an abundance of energy, my family would catch

me ironing at 11pm, unheard of before NDT. I felt fantastic and understood what

many people had wrote on this forum and others about feeling as though someone

had just switched the lights on. Everything appeared brighter, sharper and it

just felt great to be a live.

Unfortunately for me, since then despite remaining on Natural Dessicated

Thyroid things have gone down hill and I am trying to work out what is going

on, with the help of this site and the wonderful people who contribute, a huge

thank you, by the way. I'm looking at vitamin and minerals first of all.

What I would like to ask in this post is this, is it really possible to stay

feeling wonderful and energetic and able to live life to the full when all

vitamin, mineral and other factors have been taken into account. I guess I am

needing some hope today.

I look forward to any responses.

Annie xx

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[Guest guest]

Hi Annie,

You still need to pace yourself and not go mad. If I do too much and late

nights (rare), I get run down briefly.

Yes you must look at vit and mins and supplement wisely and also take into

account what Sheila has mentioned abotu other factors - but - you have a family

and I see you are ironing at 11pm - so I am guessing that you could allow

yourself to go over and above to keep everyone happy and your new found energy

it is tempting.

Be good to yourself, have rest and relaxation and remember that it is great to

fire on all cylinders but R & R is just as important - it does not mean you have

to stop feeling healthy and vital.

Good luck,

Stacey