Forewarded A very Technical warning about long term use of of MMS

[Guest guest]

Joyce sent this to be forewarded to our group because she beleives we

should air the good and possible bad about MMS.She has permission of

the original poster Jim Yates at another discussion group. I agree we

need to know all things .But this is very technical and

I need an interpreter.

It would be nice to have a frame of reference from

the discussion that led up to this very technical

assessment so people can know what this is about. It

might make it easier to understand.

Am I right in thinking the main point is that long

term use of MMS may not be as safe as we hope?

IN NC

On 10/10/07, joyce la fleur <loveandlight1111@...> wrote:

--Hi Jim, Do u care if I post this to other MMS sites.

Thanks for sending this. Keep me posted if u see any

thing else. Blessings to your day Joyce

- Jim Yates <mongeezer@... > wrote:

No, I have no objection. I'm not against the use of MMS, but I would

be leery of using it everyday as a preventative (until we know more

about it). If I had a stubborn dread disease like Lyme's, I would

take it as long as necessary.

Free Radic Res, 2004 Jul, 38(7), 739 - 50

A comparison of the effects of ocular preservatives

on mammalian and

microbial ATP and glutathione levels; Ingram PR et

al.; The aim of this

study was to investigate the mechanism of action of

the preservative sodium

chlorite (NaClO2), and the relationship with

intracellular glutathione

depletion . A detailed comparison of the dose

responses of two cultured

ocular epithelial cell types and four species of

microorganism was carried

out, and comparisons were also made with the

quaternary ammonium compound

benzalkonium chloride (BAK), and the oxidant

hydrogen peroxide (H2O2) . The

viability of mammalian and microbial cells was

assessed in the same way, by

the measurement of intracellular ATP using a

bioluminescence method .

Intracellular total glutathione was measured by

reaction with

5,5'-dithiobis-2-nitrobenzoic acid in a glutathione

reductase-dependent

recycling assay . BAK and H2O2 caused complete

toxicity to conjunctival and

corneal epithelial cells at approximately 25 ppm, in

contrast to NaClO2,

where > 100 ppm was required . The fungi Candida

albicans and Alternaria

alternata had a higher resistance to NaClO2 than the

bacteria Staphyloccus

aureus and Pseudomonas aeruginosa, but the bacteria

were extremely resistant

to H2O2 . NaClO2 caused substantial depletion of

intracellular

glutathionein all cell types, at concentrations

ranging from <10> 500

ppm in fungal

cells . The mechanisms of cytotoxicity of NaClO2,

H2O2 and BAK all appeared

to differ . NaClO2 was found to have the best

balance of high antibacterial

toxicity with low ocular toxicity . The lower

toxicity of NaClO2 to the

ocular cells, compared with BAK and H2O2, is in

agreement with fewer

reported adverse effects of application in the eye.

http://lib.bioinfo.pl/pmid:15453639

< http://tinyurl.com/22d3mn> It might be

good to supplement with NAC

<http://www.gsh-booster.com/needagshboost.htm> to

keep GSH at a healthy level.

~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~

Fundam Appl Toxicol, 1984 Jun, 4(3 Pt 1), 479 - 84

Pharmacodynamics of alcide, a new antimicrobial

compound, in rat and rabbit;

Scatina J et al.; Alcide is a germicidal preparation

which has been shown to

kill a wide range of common pathogenic bacteria as

well as fungi, in vitro .

This preparation is composed of Part A and Part B

which contains sodium

chlorite (NaClO2) and lactic acid as the active

ingredients, respectively .

The two parts are combined in equal volumes

immediately prior to application

resulting in the formation of chlorine dioxide

(ClO2) . Alcide gel was

applied to the shaven backs of 18 female

Sprague-Dawley rats in a 2.0-g/kg

dose by combining 1 g of each part immediately prior

to administration .

This dose was applied for a period of 10 days to

reach a steady state . On

the 11th day, 36Cl-labeled Alcide gel, which

contained Na36ClO2 in Part A,

was administered to the animals in a 0.6-g dose (2.0

g/kg) containing

0.1microCi . The half-life for 36Cl absorption was

22.1 hr while the elimination half-life was 64.0 hr

. 36Cl was excreted by

the kidneys with chloride (Cl-) and chlorite as the

metabolites . Ninety-six

hours after Alcide administration, radioactivity was

highest in whole blood

and lowest in fat . In a 90-day subchronic dermal

toxicity study in rabbits,

exposure to Alcide gel resulted in decreased

glutathione concentrations in

blood of the group receiving 2.0 g/kg Alcide as well

as in the placebo gel

group which received the same dose of gel.

http://toxsci.oxfordjournals.org/cgi/content/abstract/4/3part1/479

~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~

Significantly decreased testicular deoxyribonucleic

acid (DNA) synthesis was

noted in male rats given

chlorine dioxide or chlorite (as sodium salt) in the

drinking water for 3

months at concentrations that

resulted in estimated chlorine dioxide and chlorite

doses ¡Ã1.3 and

0.13mg/kg/day, respectively(Abdel-

Rahman et al. 1984b), and other male rats exposed

for 3 weeks to a

concentration that resulted in a

chlorine dioxide dose of 13 mg/kg/day or a chlorite

dose of 1.3 mg/kg/day

(Suh et al. 1983).

http://www.atsdr.cdc.gov/toxprofiles/tp160-c3.pdf

--

¢® n /\n7 !

Jim Yates

[Guest guest]

Ok, I'm skimming the archives. Found this post early on. Am I getting it

right? Does it imply long term use of MMS depletes the glutathione levels?

Looks like most of the early people have left the building.

Oh, I also found another post stating the shelf life is around 2-4 years. Maybe

that explains why I'm not having as strong a reaction to it.

I'm thinking this is probably not something that should be used all the time,

not even a maintenance dose. That's my thinking on it anyway. Probably good to

kill off some cooties but not long term use.

Any thoughts, anybody?

Gail

>

> No, I have no objection. I'm not against the use of MMS, but I would

> be leery of using it everyday as a preventative (until we know more

> about it). If I had a stubborn dread disease like Lyme's, I would

> take it as long as necessary.

>

>

>

>

> Free Radic Res, 2004 Jul, 38(7), 739 - 50

> A comparison of the effects of ocular preservatives

> on mammalian and

> microbial ATP and glutathione levels; Ingram PR et

> al.; The aim of this

> study was to investigate the mechanism of action of

> the preservative sodium

> chlorite (NaClO2), and the relationship with

> intracellular glutathione

> depletion . A detailed comparison of the dose

> responses of two cultured

> ocular epithelial cell types and four species of

> microorganism was carried

> out, and comparisons were also made with the

> quaternary ammonium compound

> benzalkonium chloride (BAK), and the oxidant

> hydrogen peroxide (H2O2) . The

> viability of mammalian and microbial cells was

> assessed in the same way, by

> the measurement of intracellular ATP using a

> bioluminescence method .

> Intracellular total glutathione was measured by

> reaction with

> 5,5'-dithiobis-2-nitrobenzoic acid in a glutathione

> reductase-dependent

> recycling assay . BAK and H2O2 caused complete

> toxicity to conjunctival and

> corneal epithelial cells at approximately 25 ppm, in

> contrast to NaClO2,

> where > 100 ppm was required . The fungi Candida

> albicans and Alternaria

> alternata had a higher resistance to NaClO2 than the

> bacteria Staphyloccus

> aureus and Pseudomonas aeruginosa, but the bacteria

> were extremely resistant

> to H2O2 . NaClO2 caused substantial depletion of

> intracellular

> glutathionein all cell types, at concentrations

> ranging from <10> 500

> ppm in fungal

> cells . The mechanisms of cytotoxicity of NaClO2,

> H2O2 and BAK all appeared

> to differ . NaClO2 was found to have the best

> balance of high antibacterial

> toxicity with low ocular toxicity . The lower

> toxicity of NaClO2 to the

> ocular cells, compared with BAK and H2O2, is in

> agreement with fewer

> reported adverse effects of application in the eye.

> http://lib.bioinfo.pl/pmid:15453639

> < http://tinyurl.com/22d3mn> It might be

> good to supplement with NAC

> <http://www.gsh-booster.com/needagshboost.htm> to

> keep GSH at a healthy level.

>

> ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~

> Fundam Appl Toxicol, 1984 Jun, 4(3 Pt 1), 479 - 84

> Pharmacodynamics of alcide, a new antimicrobial

> compound, in rat and rabbit;

> Scatina J et al.; Alcide is a germicidal preparation

> which has been shown to

> kill a wide range of common pathogenic bacteria as

> well as fungi, in vitro .

> This preparation is composed of Part A and Part B

> which contains sodium

> chlorite (NaClO2) and lactic acid as the active

> ingredients, respectively .

> The two parts are combined in equal volumes

> immediately prior to application

> resulting in the formation of chlorine dioxide

> (ClO2) . Alcide gel was

> applied to the shaven backs of 18 female

> Sprague-Dawley rats in a 2.0-g/kg

> dose by combining 1 g of each part immediately prior

> to administration .

> This dose was applied for a period of 10 days to

> reach a steady state . On

> the 11th day, 36Cl-labeled Alcide gel, which

> contained Na36ClO2 in Part A,

> was administered to the animals in a 0.6-g dose (2.0

> g/kg) containing

> 0.1microCi . The half-life for 36Cl absorption was

> 22.1 hr while the elimination half-life was 64.0 hr

> . 36Cl was excreted by

> the kidneys with chloride (Cl-) and chlorite as the

> metabolites . Ninety-six

> hours after Alcide administration, radioactivity was

> highest in whole blood

> and lowest in fat . In a 90-day subchronic dermal

> toxicity study in rabbits,

> exposure to Alcide gel resulted in decreased

> glutathione concentrations in

> blood of the group receiving 2.0 g/kg Alcide as well

> as in the placebo gel

> group which received the same dose of gel.

>

> http://toxsci.oxfordjournals.org/cgi/content/abstract/4/3part1/479

>

> ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~

> Significantly decreased testicular deoxyribonucleic

> acid (DNA) synthesis was

> noted in male rats given

> chlorine dioxide or chlorite (as sodium salt) in the

> drinking water for 3

> months at concentrations that

> resulted in estimated chlorine dioxide and chlorite

> doses ¡Ã1.3 and

> 0.13mg/kg/day, respectively(Abdel-

> Rahman et al. 1984b), and other male rats exposed

> for 3 weeks to a

> concentration that resulted in a

> chlorine dioxide dose of 13 mg/kg/day or a chlorite

> dose of 1.3 mg/kg/day

> (Suh et al. 1983).

> http://www.atsdr.cdc.gov/toxprofiles/tp160-c3.pdf

>

> --

> ¢® n /\n7 !

> Jim Yates

>

[Guest guest]

On 10/1/2009, wanda85929 (wanda85929@...) wrote:

> Ok, I'm skimming the archives. Found this post early on. Am I

> getting it right? Does it imply long term use of MMS depletes the

> glutathione levels?

Since it (chlorine dioxide) is a powerful oxidizer, it would most likely

deplete the levels of all anti-oxidants in the body (one of which is

glutathione).

It also supposedly depletes minerals/elctrolytes.

You can minimize the negative effects by properly supplementing in

between MMS1 doses - day on day off, or 2 days on, 1 day off, or some

variation on that.

For me, it would depened on what I was trying to fight (for cancer I'd

be hitting the MMS (1 and 2) pretty hard, but for a cold, maybe one or

two big doses).

MMS2 is a different animal. I don't think it has the same negative long

effetcs, long or short term - but of course I could be very wro, ausig

ths stuff inteally is still very new.

> Looks like most of the early people have left the building.

>

> Oh, I also found another post stating the shelf life is around 2-4

> years. Maybe that explains why I'm not having as strong a reaction

> to it.

That may depend on how it was stored too... I seem to recall it should

be stored in a cool, dark place...

> I'm thinking this is probably not something that should be used all

> the time, not even a maintenance dose. That's my thinking on it

> anyway. Probably good to kill off some cooties but not long term

> use.

As for anything except food, yes...

--

Best regards,

[Guest guest]

--- In , Tanstaafl <tanstaafl@...>

wrote:

>

>

>

> It also supposedly depletes minerals/elctrolytes.

>

>

Thank you, .

This time around it doesn't seem to be bothering my heart whatsoever, but I have

noticed after taking it, my feet will start to cramp. Just took some trace

minerals. Hadn't made the connection.

It does seem to be helping me feel better so for now I'm going to continue on it

a while and just play it by ear, listening to my body.

Thanks again,

Gail

[Guest guest]

MMS lasts from 2 to 4 years, if not exposed to light. You can tell if it is still 'good' because when you mix it up you should smell chlorine and the mix should turn slightly to very yellow, depending on the acid you use. Direct sunlight will destroy it in an hour.

You may not be having a strong reaction because you do not have many virus or bacteria in your system?

If you do take it, don't take it for an extended period of time once you are 'well'. Also be sure to take vit. C and some probiotics as there are those that feel MMS1 strips C from the body, plus kills good gut flora along with the bad.

I don't feel it's for every day use once you are over whatever you were taking it for. Tops would be twice a week as a preventative.

Samala,

-------Original Message-------

Oh, I also found another post stating the shelf life is around 2-4 years. Maybe that explains why I'm not having as strong a reaction to it.

I'm thinking this is probably not something that should be used all the time, not even a maintenance dose.