Decline in immunity to polio among young adults

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http://www.elsevier.nl/gej-ng/10/42/35/40/46/34/abstract.html

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Vaccine, Vol. 19 (30) (2001) pp. 4162 - 4166

=A9 2001 Elsevier Science Ltd. All rights reserved.=20

PII: S0264-410X(01)00165-7

Decline in immunity to polio among young adults

Itamar Grotto a,b, Handsher c, Gdalevich a,b, Mimouni

a, Huerta a, Manfred S. Green b,d, Ella Mendelson c and Ofer

Shpilberg a,b * ofers@...=20

a Israel Defence Forces, Medical Corps, Military Post 02149, Israel

b Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel

c Ministry of Health, Central Virology Laboratory, Tel-Hashomer, Israel

d Ministry of Health, The Israel Center for Disease Control (ICDC),

Tel-Hashomer, Israel=20

Received 4 January 2001; received in revised form 29 March 2001; accepted

23 April 2001

Abstract

A serologic survey was conducted on a population-based representative

sample of 521 18-year-old soldiers recruited to the Israel Defence Forces

in 1997. The prevalence of neutralizing antibodies and geometric mean

titers (GMTs) against the three types of poliovirus (Mahoney, MEF and

Saukett strains) were found to be 98.7% (GMT 169.95), 99.6% (GMT 297.14)

and 96.4% (GMT 59.48), respectively. These GMTs are markedly lower than

those recorded 4 years after booster vaccination carried out during a 1988

polio outbreak, and suggest a decline in immunity against polio among young

adults. These findings support the policy of routine revaccination of

children and adolescents in countries at risk of imported polioviruses and

of revaccination of adults traveling to areas to which polio is endemic.

Keywords: Poliovaccine; Antibodies; Immunity

*Corresponding author. Present address: Soroka University Medical Center,

POB 151, Beer-Sheva 84101, Israel. Tel.: +972-8-6403325; fax: +972-8-6400195=

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[Full text] (PDF 102.8 Kb)=20

=A9 Copyright 2001, Elsevier Science, All rights reserved.

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Sheri Nakken, R.N., MA=09

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