Towards the rational design of Th1 adjuvants

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http://www.elsevier.nl/gej-ng/10/42/35/40/47/32/abstract.html

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Vaccine, Vol. 19 (31) (2001) pp. 4363 - 4372

=A9 2001 Published by Elsevier Science Ltd. All rights reserved.=20

PII: S0264-410X(01)00193-1

Towards the rational design of Th1 adjuvants

P. Moingeon * philippe.moingeon@... , J. Haensler and A. Lindberg

Aventis Pasteur, Department of Research and Development, Campus M=E9rieux,

1541 avenue Marcel M=E9rieux, 69280 Marcy l'Etoile, France=20

Received 26 February 2001; received in revised form 17 May 2001; accepted

22 May 2001

Abstract

Finding adjuvants in order to enhance immune responses against target

immunogens has been a major and recurrent issue for the vaccine industry.

It is yet to be solved, most particularly in the context of a growing

interest in designing new types of vaccines capable of eliciting Th1 immune

responses. A review of synthetic adjuvants which have been (or are being)

tested in clinical studies is presented. Importantly, recent advances in

our understanding of the physiology of immune responses offer new avenues

to design and test candidate adjuvants, based on either synthetic or

natural molecules, with the aim to mimic and recapitulate pro-inflammatory

signals initiating both innate and adaptative immune effector mechanisms.

Thus, adjuvants of the future might be a mixture of molecules selected

singularly for a capacity to attract, target or activate professional

antigen presenting cells. Used as a combination, such molecules should

facilitate antigen presentation by professional APCs and lead to a potent

induction of T cell-mediated effector and immune memory mechanisms.

Keywords: Adjuvant; Vaccine design; Th1 response

Abbreviations: APC, antigen presenting cell(s); DC, dendridic cell(s); LPS,

lipopolysaccharide; TLR, Toll-like receptor(s)

*Corresponding author. Tel.: +33-4-3737-3807; fax: +33-4-3737-3582=20

[Full text] (PDF 133.7 Kb)=20

=A9 Copyright 2001, Elsevier Science, All rights reserved.

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