Re: Detoxing with mms and restless legs

November 29, 2007

Hi Bob-

My husband has trouble with restless legs,

off and on. What works for him is taking white willow bark. I also find it

useful for pain and seldom use ibuprofen or aspirin (which never did anything

for me anyway).

Best,

Dana

From: [mailto: ] On Behalf Of Bob

But doe's anybody here know of some thing use-full

that helps restless legs.....? Daddybob......, Any suggestions.....?

Thanks all.

Bob.

November 30, 2007

Magnesium and potassium supplementation. You may need more than oral magnesium. I use transdermal magnesium to get extra into my system. - S.

-- [ ] Detoxing with mms and restless legs

Hi all

I have a question maybe someone can answer. After suffering for years

with many symptoms to numerous to mention, All of these little

symptoms finally cascaded into a locked up lower back, Inflammation

around both hip joints and the prostate area. Not to mention extreme

brain fog and fatigue that has literally turned me into a looser and

put me on the floor. I finally figured out it was the mercury in my

mouth, Which I have not been able to afford to have it taken out yet.

Now the good part. After taking MMS and having lots of the famous

bathroom visits and some very "serious" herxing, This stuff is

seriously driving this poison out of my back, My hips and the

prostate. Absolutely unbelievable. It seems to work on the latest

symptom first, Then on the next latest symptom. Now it working on my

upper legs where I have had some inflammation that was causing some

stiffness. As it is doing this I have had some serious leg jerking

going on when I go to bed. I can feel tingles right where my legs

attach to my hips, And that is where the short circuit that makes my

legs jerk seem to be occurring. I am sure after the MMS drives this

out it will stop, But doe's anybody here know of some thing use-full

that helps restless legs.....? Daddybob......, Any suggestions.....?

Thanks all.

Bob.

November 30, 2007

Hello Bob.

(Bob wrote " Subject: [ ] Detoxing with mms and

restless legs "

" Hi all ...

Then on the next latest symptom. Now it working on my

upper legs where I have had some inflammation that was causing some

stiffness. As it is doing this I have had some serious leg jerking

going on when I go to bed. I can feel tingles right where my legs

attach to my hips, And that is where the short circuit that makes my

legs jerk seem to be occurring. I am sure after the MMS drives this

out it will stop, But doe's anybody here know of some thing use-full

that helps restless legs.....? Daddybob......, Any suggestions.....?

Thanks all.

Bob. "

This may be the Restless Leg Syndrome " ... unpleasant deep discomfort inside

the calves ... producing an irresistible urge to move the legs etc.

I have experienced it, and I believe it occurs when the losses of bone

minerals due to acidity (acidosis, that leads to osteoporosis) gets to the

point that the strength of the bone is compromised. By my understanding, the

bone matrix becomes weakened to the point that adjacent remaining minerals

have to re-consolidate (to close up some of the gaps) lest the bone might

fracture. The good thing about RLS is that slowly you do not have quite so

far to fall as your bones collapse.

When I came to appreciate this concept I increased my intake of greens to

try to supply enough alkalinity to neutralize the acidity in my body. This

involves quite big changes. Have you any choice? -- you could try having

antacids but they will never properly supply your body with the minerals it

requires. Does my approach work? --yes, it does, And it has geatly reduced

the rate at which my body was degenerating.

If I can help more, e-mail me.

Phil

November 30, 2007

Hi List,

I think this is my first post since joining this group.

Reading about Bob's Restless Legs, then seeing a few posts here related to iron

and MMS, something clicked and I went into my files. Sure enough, here's one

about RLS and iron: (hope this helps, Bob. Sharon M)

*************

Sleep [2005] 28 (9) : 1069-1075

(Earley CJ, Connor JR, Beard JL, Clardy SL, RP.)

Ferritin levels in the cerebrospinal fluid and restless legs syndrome: effects

of different clinical phenotypes.

STUDY OBJECTIVE: To determine whether patients with restless legs syndrome (RLS)

and controls differ in regard to levels of ferritin and transferrin in the

cerebrospinal fluid (CSF) when samples are collected at night, to determine

whether patients with early-onset and late-onset RLS show a different outcome

for CSF values, and to determine whether the CSF ferritin level correlates with

disease severity.

DESIGN: Collection of CSF and plasma; assessment of disease severity using

objective (periodic limb movements) and subjective (s Hopkins Restless Legs

Severity Scale) measures of severity.

SETTING: General Clinical Research Center.

PARTICIPANTS: Thirty subjects with idiopathic RLS (15 early- and 15 late-onset

RLS) and 22 age- and sex-matched controls.

INTERVENTION: N/A.

RESULTS: Nighttime CSF ferritin levels were lower in the total RLS group

compared with controls. Further assessment found that the early-onset (less than

45 years of age) but not the late-onset (greater than or equal to 45 years of

age) RLS group had significantly lower CSF ferritin levels compared with

controls. There was a strong correlation between the age of symptom onset and

CSF ferritin values (r = 0.64): the earlier the age, the lower the ferritin

level. A regression analysis showed that both sex and RLS subtype had

significant effects on the CSF ferritin level, with women with early-onset RLS

having substantial lower values than men with late-onset RLS. A comparison

between these nighttime CSF values and previously published daytime samples

suggests that diurnal changes may have effects on the findings.

CONCLUSIONS: This study is distinct in showing that the degree of the

CSF-ferritin effect is best defined by the clinical phenotypes of sex and age of

symptom onset and by the time of day that samples are collected.

Posted: Thu May 25, 2006 10:56 pm Post subject: Ferritin levels are

decreased in RLS

--------------------------------------------------------------------------------

The Journal of Laboratory and Clinical Medicine [2006] 147 (2) : 67-73

(Clardy SL, Earley CJ, RP, Beard JL, Connor JR.)

Ferritin subunits in CSF are decreased in restless legs syndrome.

Restless legs syndrome (RLS) is a neurological disorder that may be related to

iron misregulation at the level of the central nervous system. Evidence that

iron is involved in RLS comes from magnetic resonance imaging data, autopsy

studies, analyses of cerebrospinal fluid (CSF), and correlations of symptoms

with serum ferritin.

Methods : To further examine the possibility that brain iron status is

insufficient in RLS, we determined ferritin levels in the CSF. Specifically, we

differentiated between the H- and L-subunits of ferritin, because these peptides

are expressed from different chromosomes and have different functions. We

measured H- and L-ferritin subunit levels in control and RLS human CSF using

immunoblot analysis and found that both H- and L-ferritin are significantly

decreased in early but not late-onset RLS. Additionally, we quantified total

protein in each CSF sample to establish that the decrease in ferritin subunits

in RLS did not reflect a decrease in total protein in CSF. Furthermore, we used

equal amounts of total CSF protein in the immunoblot analyses, in contrast to

previously published studies that provided only volumetric data, to determine

which approach was more accurate for quantifying the amount of ferritin relative

to other proteins in CSF.

Results : Our results establish a protein standard in RLS, provide a comparative

analysis of protein-controlled versus volumetric immunoblot techniques, and

argue for a profound loss of iron storage capacity in the brain in RLS,

specifically in the early onset RLS phenotype.

Conclusions : These data suggest that CSF ferritin levels may provide a

biomarker for assisting in the diagnosis of RLS.

--------------------------------------------------------------------------------\

----

Neurology [2005] 64: 1920-1924

(Högl B et al)

Study supports iron deficiency theory in restless legs syndrome

Austrian and Italian researchers find a high prevalence and under-recognition of

restless legs syndrome in the general community.

In white adults in Europe and the USA, very similar prevalence rates of restless

legs syndrome (RLS) of about 10 per cent have been reported. The distribution of

disease severity in the general population has not been investigated

systematically. Although the negative impact of RLS on quality of life is beyond

doubt, very few patients receive drug treatment. Decreased iron concentrations

in the substantia nigra and nucleus ruber have been suggested in a study of

patients with RLS.

Dr B Högl and colleagues assessed the prevalence and severity of RLS in the

general community and investigated its potential relationship with iron

metabolism and other potential risk factors. This was a cross-sectional study of

a sex- and age-stratified random sample of the general population (Bruneck

study), which included 701 people aged 50-89. The diagnosis of RLS was

established by interviews, and severity was graded on the RLS severity scale.

Each subject underwent a thorough clinical examination and extensive laboratory

testing.

The prevalence of RLS was 10.6 per cent (14.2 per cent in women, 6.6per cent in

men); 33.8 per cent of all patients with RLS had mild, 44.6 per cent had

moderate, and 21.6 per cent had severe disease expression. None had been

previously diagnosed. Free serum iron, transferrin and ferritin concentrations

were similar in subjects with and without RLS. However, soluble transferrin

receptor (sTR) concentrations were higher in subjects with RLS. Female sex and

high sTR independently predicted the risk of RLS.

Dr Högl and co-workers stated, " The finding of a significant association between

high sTR concentrations, a sensitive marker of incipient systemic iron

deficiency, and RLS in the Bruneck study lends the first epidemiologic support

to the iron deficiency hypothesis. " He added, " Although two-thirds of patients

had moderate to severe disease, none was on current dopaminergic therapy. "

From: " Bob " <winestien@...>

> I have a question maybe someone can answer. After suffering for years

> with many symptoms to numerous to mention, All of these little

> symptoms finally cascaded into a locked up lower back, Inflammation

> around both hip joints and the prostate area. Not to mention extreme

> brain fog and fatigue that has literally turned me into a looser and

> put me on the floor. I finally figured out it was the mercury in my

> mouth, Which I have not been able to afford to have it taken out yet.

> Now the good part. After taking MMS and having lots of the famous

> bathroom visits and some very " serious " herxing, This stuff is

> seriously driving this poison out of my back, My hips and the

> prostate. Absolutely unbelievable. It seems to work on the latest

> symptom first, Then on the next latest symptom. Now it working on my

> upper legs where I have had some inflammation that was causing some

> stiffness. As it is doing this I have had some serious leg jerking

> going on when I go to bed. I can feel tingles right where my legs

> attach to my hips, And that is where the short circuit that makes my

> legs jerk seem to be occurring. I am sure after the MMS drives this

> out it will stop, But doe's anybody here know of some thing use-full

> that helps restless legs.....? Daddybob......, Any suggestions.....?

November 30, 2007

Hi Starshar

Good work - but I suspect the true cause of RLS is still a deficiency of

alkaline nutrients (ie mal-nutrition) (insufficiency of alkaline versus acid

(ash-residue) nutrients in the diet.

Phil

Ferritin levels are

decreased in RLS

--------------------------------------------------------------------------------

The Journal of Laboratory and Clinical Medicine [2006] 147 (2) : 67-73

(Clardy SL, Earley CJ, RP, Beard JL, Connor JR.)

Ferritin subunits in CSF are decreased in restless legs syndrome.

Restless legs syndrome (RLS) is a neurological disorder that may be related

to iron misregulation at the level of the central nervous system. Evidence

that iron is involved in RLS comes from magnetic resonance imaging data,

autopsy studies, analyses of cerebrospinal fluid (CSF), and correlations of

symptoms with serum ferritin.

Methods : To further examine the possibility that brain iron status is

insufficient in RLS, we determined ferritin levels in the CSF. Specifically,

we differentiated between the H- and L-subunits of ferritin, because these

peptides are expressed from different chromosomes and have different

functions. We measured H- and L-ferritin subunit levels in control and RLS

human CSF using immunoblot analysis and found that both H- and L-ferritin

are significantly decreased in early but not late-onset RLS. Additionally,

we quantified total protein in each CSF sample to establish that the

decrease in ferritin subunits in RLS did not reflect a decrease in total

protein in CSF. Furthermore, we used equal amounts of total CSF protein in

the immunoblot analyses, in contrast to previously published studies that

provided only volumetric data, to determine which approach was more accurate

for quantifying the amount of ferritin relative to other proteins in CSF.

Results : Our results establish a protein standard in RLS, provide a

comparative analysis of protein-controlled versus volumetric immunoblot

techniques, and argue for a profound loss of iron storage capacity in the

brain in RLS, specifically in the early onset RLS phenotype.

Conclusions : These data suggest that CSF ferritin levels may provide a

biomarker for assisting in the diagnosis of RLS.

--------------------------------------------------------------------------------\

----

Neurology [2005] 64: 1920-1924

(Högl B et al)

Study supports iron deficiency theory in restless legs syndrome

Austrian and Italian researchers find a high prevalence and

under-recognition of restless legs syndrome in the general community.

In white adults in Europe and the USA, very similar prevalence rates of

restless legs syndrome (RLS) of about 10 per cent have been reported. The

distribution of disease severity in the general population has not been

investigated systematically. Although the negative impact of RLS on quality

of life is beyond doubt, very few patients receive drug treatment. Decreased

iron concentrations in the substantia nigra and nucleus ruber have been

suggested in a study of patients with RLS.

Dr B Högl and colleagues assessed the prevalence and severity of RLS in the

general community and investigated its potential relationship with iron

metabolism and other potential risk factors. This was a cross-sectional

study of a sex- and age-stratified random sample of the general population

(Bruneck study), which included 701 people aged 50-89. The diagnosis of RLS

was established by interviews, and severity was graded on the RLS severity

scale. Each subject underwent a thorough clinical examination and extensive

laboratory testing.

The prevalence of RLS was 10.6 per cent (14.2 per cent in women, 6.6per cent

in men); 33.8 per cent of all patients with RLS had mild, 44.6 per cent had

moderate, and 21.6 per cent had severe disease expression. None had been

previously diagnosed. Free serum iron, transferrin and ferritin

concentrations were similar in subjects with and without RLS. However,

soluble transferrin receptor (sTR) concentrations were higher in subjects

with RLS. Female sex and high sTR independently predicted the risk of RLS.

Dr Högl and co-workers stated, " The finding of a significant association

between high sTR concentrations, a sensitive marker of incipient systemic

iron deficiency, and RLS in the Bruneck study lends the first epidemiologic

support to the iron deficiency hypothesis. " He added, " Although two-thirds

of patients had moderate to severe disease, none was on current dopaminergic

therapy. "