Could Cancer, Leukemia, HIV/AIDS, Alcohol Abuse, Lou Gehrig's Disease, and Macular Degeneration sufferers benefit from the research of ? .eml

[Guest guest]

www.jsr1936.com jsr1936@... October 19,1999

Dear Reader,

In July, 1999, I posted to The INTERNET my research www.jsr1936.com, The Cure for Cancer? in which I describe possible solutions to alleviate the symptoms of Cancer, HIV/AIDS, Alcohol Abuse, Lou Gehrig's Disease, and Macular Degeneration.

Last week I may have discovered a way to alleviate the suffering of those afflicted with Chronic Myelogenous Leukemia.

Thanks to Mrs. Judy Singer, founder of the e-mail group 'fightforlifeonelist' I became aware of 'Penicillamine'.

What is Penicillamine?

My reference sources state that penicillamine is:

" a chelating agent used to treat people with 's disease, cystinuria and severe rheumatoid arthritis. "

" a chelating agent C5H11NO2S produced by the degradation of penicillin, used in the treatment of severe rheumatoid arthritis and in heavy metal poisoning. "

" a hydrolytic degradation product of penicillin. It is used to treat copper, mercury, zinc, or lead poisoning. It promotes the urinary excretion of these metals... "

" a degradation product of penicillin; a chelating agent used in the treatment of lead poisoning, hepatolenticular degeneration and cystinuria and in the removal of excess copper in 's disease... "

1999 update - " Patients who are allergic to penicillin may theoretically have cross-sensitivity to penicillamine. The possibility of reactions from contamination of penicillamine by trace amounts of penicilliin has been eliminated now that penicillamine is being produced synthetically rather than as a degradation product of penicillin. "

" Penicillamine is a chelating agent used in the treatment of 's disease. It is also used to reduce cystine excretion in cystinuria and to treat patients with severe, active rheumatoid arthritis unresponsive to conventional therapy... "

If you type " Penicillamine and Leukemia " into 'MedLine' (www.ncbi.nlm.nih.gov/pubmed) you will find that there are 23 entries (as of October 19,1999) which are devoted to this subject. I have found the following one to be most interesting; the Unique Identifier number is 96273151; I have highlighted one sentence:

" D-penicillamine (PSH) is a copper chelator that generates hydrogen peroxide and inhibits neovascularization. As hydrogen peroxide is toxic to some tumor cells and to blood vessels, we reasoned that PSH plus copper would inhibit tumors in vivo and in vitro. To test this hypothesis, we first incubated murine J558L plasmacytoma cells with varying combinations of drug (PSH and/or copper sulfate) plus modulators (fetal calf serum, dithiothrietol, catalase, eosinophil peroxidase) and then used fluorescence microscopy to measure cell proliferation, necrosis, and apoptosis. We also incubated various types of human tumor cells with PSH plus copper for 24 hours and then measured the number of surviving cells 24 hours later. For the in vivo studies, we measured the effects of 7 daily i.p. injections of 10 mg of PSH on the growth rates of interleukin-5 genetransfected J558L tumors in 20 BALB/c mice. Our experiments demonstrated that PSH plus copper exerted a significant antiproliferative effect on tumor cells in vitro that was neutralized by protein or catalase and enhanced by adherent eosinophil peroxidase. HUMAN ACUTE MYELOGENOUS LEUKEMIA CELLS WERE ESPECIALLY SENSITIVE TO PSH PLUS COPPER. In vivo, however, PSH had no significant effect on the growth rates of J558L tumors that were infiltrated by eosinophils. We conclude that the interaction of PSH-copper with tumors is primarily antiproliferative, mediated by hydrogen peroxide and inhibitable by protein. Therefore, for PSH to be an effective antineoplastic drug strategies will need to be developed to prevent its rapid neutralization by protein. "

There is only one problem with penicillamine - it could be very toxic, as the Physicians Desk Reference states on page 1766, 1999 edition:

" Physicians planning to use penicillamine should thoroughly familiarize themselves with its toxicity, special dosage considerations, and therapeutic benefits. Penicillamine should never be used casually. Each patient should remain constantly under the close supervision of the physician. Patients should be warned to report promptly any symptoms suggesting toxicity. "

I wish to digress for a moment and talk about cancer.

Dear Reader, let us suppose that you saw the following report on the front page of tomorrow's newspaper:

A scientist had spent weeks struggling through the tropical rain forest in search of a rare flower whose nectar had powerful anti-cancer properties according to the experiences of the Amazonian Indians.

Finally, after a laborious trek through the sweltering heat he chanced upon a glistening meadow containing an abundance of the iridescent flowers which he had sought and which yielded enough of their golden nectar to meet his research needs.

Upon returning to the laboratory he was overjoyed to discover that the golden nectar satisfied the three goals which all anti-cancer researchers seek -

1. In cell capping of immunoglobulins

2. In the differentiation of the mold Dictyostelium discoideum

3. In the restoration of contact inhibition of Hela cells in tissue culture.

At this point he convinced the United States National Cancer Institute to sponsor his research; the specific contract number was NO1-CM-53792.

The following is the result of his research which was printed in the 'American Association for Cancer Research'; the title is " The Plasma Membrane as a Target in Anticancer Chemotherapy " .

I have highlighted two sentences.

" In recent years, a number of biochemical differences have been noted between the plasma membrane of normal and neoplastic cells (for review see D.F.H. Wallach. Membrane Molecular Biology of Neoplastic Cells. Elsevier Publishing Co., New York, 1975). The structural and functional plasma membrane alterations of neoplastically transformed cells can be reversed in tissue culture by treating the cells with dibutyryl cyclic AMP. This 'reverse transformation' seems to take place by a cyclic AMP dependent reorganization of the network of contractil microfilaments which originates in the plasma membrane and radiates to the nucleus (Puck, T.T., Proc. Natl. Acad. Sci. US 74 , 4491-4495, 1977). During the past two years, our laboratory has set up a biological screening to detect compounds able to induce reverse transformation in vivo. The screening included the test of compounds: 1) in cell capping of immunoglobulins; 2) in the differentiation of the mold Dictyostelium discoideum and ; 3) in the restoration of contact inhibition of Hela cells in tissue culture. ONE COMPOUND OUT OF 500, THE NECTAR OF A RARE AMAZONIAN FLOWER, WAS ACTIVE IN THE THREE SCREENING STEPS AND WAS ABLE TO RESTORE CONTACT INHIBITION IN HELA CELLS IN TISSUE CULTURE. This nectar has been brought to the clinics in the United States in patients of advanced metastastic progressing cancer, under the name of Norgamem. NORGAMEM COULD REPRESENT THE FIRST NON-CYTOTOXIC ANTICANCER AGENT WHICH HAS THE PLASMA MEMBRANE AS TARGET. "

Within just a few months this scientist and his colleague achieved these results upon human beings by using the nectar of this rare Amazonian flower -

" .....Histological studies showed involution and transformation into low-grade malignancies and disappearance of evidence of cancer. "

" No toxicity was observed and all regimens were equally well tolerated. Most patients had a feeling of well-being and there was no nausea, vomiting, myelo-depression, or central-nervous-system symptoms. No changes in pulmonary, cardiac, hepatic, or renal functions were found... "

" This nectar seemed to be completely nontoxic over a wide range of doses, and had considerable antitumour effect in epidermoid carcinoma of the head and neck. Definite signs of activity were observed in epidermoid carcinoma of other regions and in other solid tumours, such as breast, renal, ovary, thyroid, and parotid cancer. "

" This nectar seemed to affect only tumour cells, since no effect was observed in the normal skin, mucosae, or other epithelial tissues. The selective character of this action explained the absence of toxicity of the nectar's treatment. "

Dear Reader, what I have just told you is part fact and part fiction. Most of the scientific and medical data is factual; however, the scenario is fictional and so is one scientific 'fact'.

FACT - The research of the scientist, Gosalvez, was sponsored by the United States National Cancer Institute, contract NO1-CM-53792.

FACT - As far as I know, Gosalvez has never ventured into the Amazonian rain forest.

FACT - In his research Gosalvez never utilized the 'golden nectar of a rare Amazonian flower'; he utilized a chemical which is inexpensively obtainable to researchers; I know of at least two companies in the United States which stock it; the name of the chemical is Thiazolidine-4-carboxylic acid.

FACT - The research of Gosalvez, " The Plasma Membrane as a Target in Anticancer Chemotheraphy " was published in the 'Proceedings of the American Association for Cancer Research', volume 20, page 17; date of publication - March, 1979.

FACT - Gosalvez and his colleague 'A. Brugarolas' used this acid and not the 'golden nectar' to achieve the anti-cancer results which I have listed above; their research was published by 'The Lancet' which is one of the world's foremost and prestigious medical journals; refer to the January 12, 1980 issue, pages 68-70.

FACT - The reseach was conducted in Spain, not the United States.

Dear Reader, no longer think of the golden nectar of a rare Amazonian rain forest flower as the cure for cancer; it never existed (as far as I know); instead, think of Thiazolidine-4-carboxylic acid; it exists.

For the past 20 years, why has Thiozolidine-4-carboxylic acid been in Limbo as far as possible anti-cancer clinical trials are concerned?

Perhaps it is because of its toxicity; it is more toxic than Gosalvez and Brugarolas had initially thought.

The Alfa Aesar Chemical Company describes its toxicity thusly:

" Toxic by inhalation, in contact with skin and if swallowed. "

" Irritating to eyes, respiratory system and skin. "

" In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. "

" Wear suitable protective clothing, gloves and eye/face protection. "

" Ingestion - Rinse out mouth and drink lots of water. Seek medical attention and show physician the container details. "

However, my research has shown that vitamin C (Ascorbic acid) affords ample protection against the toxicity of Thiazolidine-4-carboxylic acid.

Now, let's return to Chronic Myelogenous Leukemia.

A relationship exists between Penicillamine and Thiazolidine-4-carboxylic acid.

The 1999 edition of the PHYSICIANS' DESK REFERENCE (PDR) states on page 1766 that penicillamine " reacts readily with formaldehyde or acetone to form a thiazolidine-carboxylic acid. "

To be accurate the PDR should have printed " a thiazolidine-4-carboxylic acid " . For instance, the Aldrich Division of Sigma-Aldrich stocks 25 different kinds of " thiazolidine-carboxylic acids " and in all cases the " -4- " appears; for example, I'll list five -

2-(1,2,3,4,5-PENTAHYDROXY-PENTYL)-THIAZOLIDINE-4-CARBOXYLIC ACID

2-(2-CHLORO-PHENYL)-THIAZOLIDINE-4-CARBOXYLIC ACID

2-(2-NITRO-PHENYL)-THIAZOLIDINE-4-CARBOXYLIC ACID

2-(3-BROMO-PHENYL)-THIAZOLIDINE-4-CARBOXYLIC ACID

2-(3-FLUORO-PHENYL)-THIAZOLIDINE-4-CARBOXYLIC ACID

I will state unequivocally that the " thiazolidine-carboxylic acid " which the PDR mentions is the same as that which I cite on pages one and two of www.jsr1936.com. I challenge the scientific and medical community of the world to refute me.

Since vitamin C (Ascorbic acid) protects against the toxicity of Thiazolidine-4-carboxylic acid, might it also protect against the toxicity of penicillamine?

Last week I called Dr. Cathcart's office; his website www.orthomed.com reads:

'ORTHOMOLECULAR MEDICINE

VITAMIN C

ROBERT F. CATHCART, M.D.'

and left this question - " Does vitamin C afford protection against the toxicity of penicillamine? "

The next day Dr. Cathcart's secretary called me and said, " He doesn't have any personal experience with what you mentioned, but in theory he could see how vitamin C could protect against penicillamine. "

I have been maintaining that the possible cure for cancer might be 'mega-doses' of Thiazolidine-4-carboxylic acid and vitamin C and 'above average' amounts of magnesium, zinc and manganese.

I will now maintain that the possible cure for Chronic Myelogenous Leukemia might be 'mega-doses' of Penicillamine plus copper and vitamin C.

A reader has written to me:

" Thanks for the info. Where would be the best source of data (about cancer) concerning this that I might obtain and give to my wife's oncologist. "

" The best source of data " that I can recommend is pages 7 to 9 of www.jsr1936.com.

Unfortunately, Mr. Jerry Rollins has not yet benefitted from this procedure; these are his words taken from The INTERNET:

August 30, 1999 - " .....I'm 65 and 18 months ago had a PSA of over 11 and was diagnosed with prostate cancer. I had 5 weeks of radiation followed by radioactive seed implant. My PSA soon went down to .2.....for 14 months. Then it went up in 2-3 months to 5.9. A definite sign that it was back (it is an aggressive cancer...I had a Gleason score of 8..very dangerous. I started taking cantron for the last 3 months and my PSA came down some and is around 5.1..... "

October 18, 1999 - " Well..here it is in a nutshell. The / (j.s.r. - Gutierrez) treatment using equal or L-thiazolidine-4-carboxylic acid, which I got in pure form from Switzerland, are useless in treating my prostate cancer. Since I started equal and then the pure acid over 6 weeks ago my PSA has gone up, in stages, from 5.1 to 8.1, a dangerous increase for that time. Whether it is because the original protocol in the 1980 Spanish tests injected the acid and I took it by mouth, or what, I don't know. My cancer type happens to be very aggressive and that could be the difference. Regardless I will spend no more time on this. Best JR "

I talked with Jerry over the telephone yesterday, and he thought the intramuscular injection method might have possibilities, but it would be a tough way to go - numerous injections would be needed.

I think that oral administration is still a viable option.

The Alfa Aesar catalog gives the Lethal Dosage amount of Thiazolidine-4-carboxylic acid as being 210 mg/kg.

Would vitamin C provide enough protection so that this amount could be administered? Perhaps even be doubled to 420 mg/kg.? Perhaps even be tripled to 630 mg/kg.? (Jerry was taking 40 mg/kg.)

I mention this possibility because I know of an occasion wherein a man swallowed everyday for five days the equivalent of 600 packets of 'Equal' which metabolizes into formaldehyde; however, because of the protection afforded by 'mega-doses' of vitamin C he suffered no ill side effects whatsoever. An 'Equal' company official stated in a television interview that 97 packets of 'Equal' per day was " too much " .

It is my continued hope that someone with medical authority will conduct a clinical trial to prove me either right or wrong in my estimation of the power of this acid to cure cancer.

Also a trial should be conducted to see if I am right or wrong about the cure for leukemia.

I wish to conclude by reminding everyone that out of the over 9,000,000 entries contained in 'MedLine', Thiazolidine-4-carboxylic acid is one of the very few substances which is specifically labelled as being " anti-cancer " (see pages 3 and 4 of www.jsr1936.com.

And this I think is the source of its power - it is hydrophobic or water repellent and will deprive the cancer cells of their ability to absorb water - thus the cancer cells will die. On page 2 of www.jsr1936.com I quote the laboratory findings of Professor V. Schally and his associates; Professor Schally is a Nobel Laureate; 'Tac' is Thiazolidine-4-carboxylic acid:

" .....The best BN antagonists of this series, RC-3950-II....., inhibited gastrin-releasing peptide-stimulated growth of Swiss 3T3 cells with IC50 values of 1 nM and 6 nM respectively. Since antagonists of this class inhibit the growth of various tumors in animal cancer models, some of them may have clinical applications. "

" .....Tac is a closed ring analog of Met and is more hydrophobic than Met. The replacement of Phe with Tac in reduced bond BN antagonists produced improved Ki and IC50 values. BN antagonists such as RC-3950-II may have important therapeutic applications for the treatment of various malignancies such as prostatic, gastric, and pancreatic cancer, small cell lung carcinoma, and other tumors. "

Sources and prices of Thiazolidine-4-carboxylic acid -

Sigma-Aldrich Cost of 10 grams - $11.80

P.O. Box 355 Cost of 100 grams - $64.80

Milwaukee, Wisconsin 53201

phone (800) 771-6737, extension 5343

FAX (414) 273-4979

Alfa Aesar Cost of 10 grams - $7.80

A Matthey Catalog Company, Inc. Cost of 50 grams - $29.80

30 Bond Street, Ward Hill Massachusetts 01835-8099 Cost of 250 grams - $132.00

phone (978) 521-6300

A Sigma-Aldrich company official has told me that they could supply the acid to the patient's physician; however, first the physician would have to file an 'Investigative New Drug Application' with the Food and Drug Administration (FDA).

After the patient's physician had obtained FDA approval, Sigma-Aldrich could send the acid to that physician and be in accordance with the law.

The Alfa Aesar company official said that the acid could be supplied to legitimate researchers but was noncommital about the possibility of supplying it to the physician of a patient.

The acid is chemically easy to make and the process is not dangerous. In addition, no one's patent right would be infringed upon if a person chose to make it or chose to have a knowledgeable high school chemistry student make it. See page 7 of www.jsr1936.com.

If you read pages 13 to 16 of www.jsr1936.com you will see that I think that L-2-Methylthiazolidine-4-carboxylic acid might be effective against HIV/AIDS.

Sigma-Aldrich could make this because it already makes 2,2-Dimethyl-Thiazolidine-4-carboxylic acid.

This acid is also chemically easy to make. In addition, no one's patent right would be infringed upon if a person chose to make it or chose to have a knowledgeable high school chemistry student make it. HOWEVER, THE PROCESS IS DANGEROUS BECAUSE ACETALDEHYDE IS FLAMMABLE AND COULD BE EXPLOSIVE! See page 14 of www.jsr1936.com.

Yours truly, S. , Post Office Box H, Hobart, Indiana 46342 (219) 763-1933

Copies to -

President Clinton, The White House, Washington, D.C.

Ms. Thurman, Director, National Aids Policy Office, The White House, Washington, D.C.

Donna E. Shalala, Ph.D., Secretary of Health and Human Services, Washington, D.C.

Satcher, M.D., Ph.D., Surgeon General of the United States of America, Rockville, land

Harold Varmus, M.D., Director, National Institutes of Health, Bethesda, land

Klausner, M.D., Director, National Cancer Institute, Bethesda, land

Professor V. Schally, Veterans Affairs Medical Center, New Orleans, Louisiana

M. Judah Folkman, M.D., Children's Hospital, Boston, Massachusetts

E. Ratcliffe , Jr., M.D., Executive Vice President and Chief Executive Officer, American Medical Association, Chicago, Illinois

M. Pluda, M.D., Senior Clinical Investigator, National Cancer Institute, Rockville, land

Mr. Jon Huntsman, Huntsman Cancer Institute, Salt Lake City, Utah

F. Cathcart, M.D., 'Orthomolecular Medicine', Los Altos, California

e-mail to various persons j.s.r.