Soy May Decrease Cancer Risks, Wake Forest Researcher Says

[Guest guest]

Subj: [fightforlife] Soy May Decrease Cancer Risks, Wake Forest Researcher

Says

Date: 7/26/99 9:15:15 PM Pacific Daylight Time

From: Radwick@...

Reply-to: fightforlifeonelist

fightforlifeonelist

From: Radwick@...

For Immediate Release 03/29/99 20:01

Soy May Decrease Cancer Risks, Wake Forest Researcher Says

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WINSTON-SALEM, N.C. - Dietary soy may reduce the risk of cancer by

counteracting the cell-proliferating effect of estrogen-replacement therapy,

a Wake Forest University researcher reported today (Jan. 25, 1999) at the

meeting of the American Association for the Advancement of Science.

J. Mark Cline, D.V.M., Ph.D., assistant professor of comparative medicine,

said that studies he conducted in postmenopausal monkeys showed that, as

expected, estrogen replacement therapy induced cell proliferation - a cancer

precursor - in both the mammary glands of the breast and in endometrial

tissue.

But when monkeys got dietary soy such as found in tofu - or soy supplements -

the cell proliferation was counteracted. " These data indicate that soy

supplements may decrease breast and endometrial cell proliferation and

therefore could decrease cancer risk in these tissues, " Cline said.

In other words, the soy protein played much the same role as progestin does

in common estrogen/progestin formulations by reducing the risk of cancer.

However, there may be some risks involved. He said the relative dose of soy

protein - which contains plant estrogens (called phytoestrogens) - and

estrogen replacement therapy may be critical.

Cline's caution came from studies he conducted in rats whose ovaries had been

removed. He tested combinations of estrogen and soy proteins. The soy

proteins did not cause an increase in cell proliferation either in the uterus

or mammary gland. But at low doses of estrogen replacement therapy, the dose

of soy estrogen found in natural soy caused an increase in cell proliferation

un the breast.

At a higher dose of estrogen replacement therapy, however, the soy diminished

the cell proliferation in both the uterus and breast. " At some dose

combinations, the two are additive, and at other dose combinations, they are

antagonistic, Cline said.

Cline said further work is needed to explore the basic mechanisms by which

soy estrogens decrease the incidence of breast cancer.

" Widespread consumption of phytochemicals in the human diet and as

supplements make it imperative that we understand their effects, particularly

as they related to differing developmental and functional stages of the

breast, " Cline said.

Cline also talked about the differences between people with apparently

similar genetic heritage, particularly Asians. " Asian diets typically contain

less fat and a higher proportion of vegetables, including soy protein, when

compared to Western diets, " he said. Striking differences in cancer rates

between Asians living in Asia and their cousins living in America has long

been known.

Perhaps more important, recent studies have shown that American-born children

of Asian immigrants have a 60 percent higher risk of developing breast cancer

than do people born in Asia who immigrate to America and now are eating

Western diets. " This implies that the breast-cancer protective effect may

occur early in life, " he said.

But the mechanism is still a mystery.

The contribution of vegetable and fiber intake to lower cancer risk is clear.

However the degree to which one can attribute the anticancer effect to

plant-derived estrogenic compounds is still uncertain. "

Cline said not all women would benefit equally from consuming estrogens in

the soy, because of individual differences both in how the soy estrogen is

metabolized and in the woman's ability to respond to the estrogen.

" The benefit of soy phytoestrogens is clearer for dietary exposures early in

life and for premenopausal women, " Cline said. " The benefit for older women

and breast cancer survivors remains to be determined. "

Cline's study was supported both by the Department of the Army and the

National Institutes of Health.

Media Contact: Conn, Jim Steele or Mark at (336) 716-4587

http://www.wfubmc.edu/cgi-bin/newsUpdate/viewNews.cgi?article=922755698

[Guest guest]

At 10:58 PM 10/23/99 EDT, you wrote:

>Subj: [fightforlife] Soy May Decrease Cancer Risks, Wake Forest

Researcher

>Says

Asians take their soy fermented.

That's the difference.