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CANCER (Grape diet)

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In a message dated 4/11/00 6:19:50 PM Eastern Daylight Time,

sandra@... writes:

<< Thanks everyone for all your input - we are looking into the Gerson Therapy

for my friend who has just been diagnosed with Lung Cancer.........just

had her first blast of radium (4days consecutively).

If any one knows about thisor Beata Bishop whereabouts re tThe Grape

Diet.............please get in touch quickly - time is short .

Many thanks

*************************************************************************

,

I am a holistic healer and a holistic researcher of fibromyaliga

and chronic fatique syndrome, and I am very familar with the

grape diet.

The grape diet works because the grapes have ellagic acid in them.

The Hollings Cancer Institute at the Medical University of South

Carolina is doing a hugh clinical study on ellagic acid that is 7 times

stronger than grapes from the seeds of the Washington Meeger red

raspberry. Moreover, they are having incredible results. The

product in question has been clinically proven to cause G-arrest

(stop cell mitosis-splitting and duplication) with 48 hours, and

cause apoptosis (a natural cell death within 72 hours)

Here is the information and let me know ASAP if you need access to the

same product that the cancer institute is testing.

Sincerely,

Steve Podhouser

healerstouch1@...

To all Oncologist's:

The Hollings Cancer instititute at the University of South Carolina

is doing a double blind study on a large group of 500 cervical cancer

patients that has everyone excited. They are excited because

their past nine years of study have shown that a natural product

called ellagic acid is causing G-arrest within 48 hours (inhibiting and

stopping mitosis-cancer cell division), and apoptosis (normal cell

death) within 72 hours, for breast, pancreas, esophageal, skin, colon

and prostate cancer cells. Clinical tests also show that ellagic

acid prevents the destruction of the p53 gene by cancer cells.

Additional studies suggest that one of the mechanisms by which

ellagic acid inhibits mutagenesis and carcinogenesis is by forming

adducts with DNA, thus masking binding sites to be occupied by the

mutagen or carcinogen.

Ellagic acid can be found in different foods, but the clinic has identified

the red raspberry as having the highest content of the acid. Moreover, the

doctors at Holling's have created a patent pending process of extracting

potent levels of the acid from the seeds of the raspberrys that are getting

dramatic results. Other USA sources substantiate the Hollings

Cancer Institute include:

Department of Surgical Oncology, College of Medicine, University of

Illinois at Chicago, Illinois; Division of Environmental Health Sciences,

The Ohio State University School of Public Health, Colombus, Ohio;

Departmant of Medicine, Lakeside Veterans Affairs Medical Center,

Northwestern University School of Medicine, Stanford, CA; Department

of Preventative Medicine, Ohio State University, Colombus, Ohio.

Here is a description of the study which came from a website of the

Washington Raspberry Commission. You can see the Hollings research

articles there.

http://www.red-raspberry.com/

Here are some notes from the site. Reprinted by permission from WRC

" The proposed study, under the direction of Nixon, M.D., President of

the American Health Foundation and Drs. Dave Gangemi and Blair Holliday of

the Hollings Cancer Center/Medical University of South Carolina, will

evaluate women with atypical squamous cells of undetermined significance

(ASCUS) in which there is neither treatment nor clinical evaluation

available. ASCUS represents as much as 10% of all Papanicolaou smears in the

US and represents approximately 5 million females. In this population, these

women who are infected with human papillomaviruses (HPV) types 16 and/or 18

are at the greatest risk of developing cervical cancer at some stage in their

lives. In addition, women who are diagnosed with the immature metaplastic

form of ASCUS usually have lesions which are higher in the endocervical

canal, are more metabolically active, have flatter surface areas, and are

more likely to invade the underlying connective tissue as well as the

endocervical glandular epithelium. This population represents approximately

one million women in the United States alone. The condition is very

pronounced in countries outside the United States. In India this is one of

the two major cancers affecting women. "

Research sources:

Cancer Lett 1999 Mar 1 1;136(2):215-21

Expression and its posssible role in G1 arrest and apoptosisi in ellagic

acid treated cancer cells.

Narayanan BA, Geoffroy O, Wilmington MC, Re GG, Nixon DWCANCER P

Prevention program, Hollings Cancer Center, Medical University of South

Carolina, ton 29425, USA.

" Ellagia acid is a phenolic compound present in fruits and nuts including

raspberries, strawberries and walnuts. It is known to inhibit certain

carcinogen-induced cancers and may have other chemopreventive

properties. The effects of ellagic acid on cell cycle events and apoptosis

were studied in cervical carcinoma (CaSki) cells. We found that ellagic

acid at a concentration of 10(-5) M induced G arrest within 48 h, inhibited

overall cell growth and induced apoptosis in CaSki cells after 72 h of

treatment. Activation of the cdk inhibitory protein p21 by ellagic acid

suggests a role for ellagic acin in cell cycle regulation of cancer cells. "

Focus: To Evaluate Red Raspberry Ellagic Acid in Prevention of Cervical Cancer

There is now clinical evidence to suggest that ellagic acid concentrations at

tissue sites such as the cervix may be obtained with the oral administration

of red raspberries. This belief comes from bioavailability studies in which

human volunteers have ingested raspberry puree. Because of this and

observations in human volunteers ingesting daily quantities of raspberry

puree for prevention of colon cancer, a clinical trial will examine ellagic

acid from raspberries in prevention of pre-cancerous cervical lesions

developing into a malignant condition.

The proposed study, under the direction of Nixon, M.D., President of

the American Health Foundation and Drs. Dave Gangemi and Blair Holliday of

the Hollings Cancer Center/Medical University of South Carolina, will

evaluate women with atypical squamous cells of undetermined significance

(ASCUS) in which there is neither treatment nor clinical evaluation

available. ASCUS represents as much as 10% of all Papanicolaou smears in the

US and represents approximately 5 million females. In this population, these

women who are infected with human papillomaviruses (HPV) types 16 and/or 18

are at the greatest risk of developing cervical cancer at some stage in their

lives. In addition, women who are diagnosed with the immature metaplastic

form of ASCUS usually have lesions which are higher in the endocervical

canal, are more metabolically active, have flatter surface areas, and are

more likely to invade the underlying connective tissue as well as the

endocervical glandular epithelium. This population represents approximately

one million women in the United States alone. The condition is very

pronounced in countries outside the United States. In India this is one of

the two major cancers affecting women.

One way to evaluate the potential progression rate in these individuals is to

monitor the levels of viral oncogene (E6/E7) messenger RNA expression in

cervical tissue. The study with evaluate women with ASCUS who have little or

no viral oncogene expression with those who have relatively elevated levels

of HPV oncogene expression.

The Study Approach & Red Raspberry Dosage

The approach will orally administer ellagic acid (using red raspberry puree,

the primary whole foods source of ellagic acid) at dosages providing

detactable tissue levels in the cervix (Phase I of proposed study) over a

two-year period (Phase II). Women in the study (to commence 1999-2000) will

be carefully evaluated for any potential adverse effects of treatment and

their E6/E7 levels carefully monitored every three months. Women receiving

treatment will then undergo a full clinical evaluation at the end of the

two-year trial period and changes in the levels of oncogene expression and in

cervical pathology determined. Changes in women receiving the red raspberry

dosage will be compared to changes in women receiving a placebo.

A biostatistician will evaluate the group sizes needed to determine a

statistically significant change in ASCUS progression following ellagic acid

(red raspberry) ingestion. Preliminary estimates indicate that five hundred

women will be needed for the generation of valid predictions. Volunteers will

be recruited from the MUSC Cancer Center Access Network, Clinics and the

State Department of Health and Environmental Control. Entry will be based on

pathological and cytological conditions discussed herein. Individuals will be

divided into low and high HPV oncogene expression groups and each group

further divided into ellagic acid and placebo groups.

Phase I Study

In Phase I, serum levels of ellagic acid will be monitored over a two-month

period. At the end of this time cervical biopsies taken to determine tissue

levels. Highly sensitive analytical techniques utilizing gas chromatographic

mass spectroscopy will be utilized to measure tissue concentrations. The

results from Phase I will be used to determine compliance rates and the daily

dosage needed to detect ellagic acid in the cervix.

Phase II Study

In Phase II, cervical swabs will be taken from volunteers will well-defined

cytopathological changes and the cells evaluated for HPV oncogene expression

using a highly sensitive biomarkers assay (reverse transcriptase-polymerase

chain reaction (RT-PCR). Individuals will receive oral dosages (to be

determined from Phase I) of raspberry puree and be reevaluated every three

months to determine the condition of their lesions (progressive, persistent,

or regressive) using immunocytochemical techniques. Phase II will be a double

blind placebo controlled study in which the research pharmacy laboratory will

keep the treatment code. At the end of the two year period, date from each

treatment group will be evaluated by a biostatistician and compared to

placebo groups for changes in the rate of progression to Low Grade Cervical

Intrepithelial Lesions (CINI). Any volunteer progressing to CINI during this

study will be removed and given conventional therapy (colposcopy and biopsy,

laser ablation, or loop excision of the transformation zone)

A barrage of clinical research at Hollings Cancer Center (ton, SC)

confirms that red raspberries, the richest food source of a substance known

as ellagic acid, inhibits the growth of cancer cells. Studies under the

direction of Dr. Nixon indicate that daily consumption of 150grams (1

cup) of red raspberries slows the growth of abnormal colon cells in humans,

prevents (in some instances destroys) the development of cells infected with

human papilloma virus (HPV) the cause of cervical cancer, and most recently

found to break down extracted human leukemia cells.

Dr. Nixon's anti-cancer prowess comes at a time when most Americans seek to

treat medical problems through changes in diet, rather than take medication.

Foods containing significant levels of biologically active components that

impart health benefits beyond basic nutrition when consumed in typical or

optimal serving sizes, are fast-becoming the hot button for consumers. Red

raspberries as the key source of cancer preventive, cancer fighting, and in

some instances cancer cell destroying ellagic acid may be the ultimate

cancer-fighting food today.

Food Sources of Ellagic Acid – micrograms/gm dry wt.

Red Raspberries1500

Strawberries630

Walnuts590

Pecans330

Cranberries120

Ellagic Acid is a naturally occurring phenolic constituent in certain fruits

and nuts. Research in the past decade confirms that ellagic acid markedly

inhibits the ability of other chemicals to cause mutations in bacteria.

Ellagic acid from red raspberries has proven as an effective antimutagen and

anticarcinogen as well as a inhibitor of cancer.

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