Vinorelbine + lymphoma

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UI - 99251376

AU - Rule S; Tighe M; Davies S; S

TI - Vinorelbine in the treatment of lymphoma.

SO - Hematol Oncol 1998 Sep;16(3):101-5

AD - Taunton and Somerset Hospital, U.K.

Seventeen patients with previously treated Hodgkin's

disease or non-Hodgkin's lymphoma (NHL) were treated

with single-agent vinorelbine (Navelbine Pierre-Fabre

Medicament) in an open study to assess the activity of

this new-generation vinca alkaloid. Responses were

obtained in four out of eight patients with Hodgkin's

disease and four out of nine patients with NHL,

including four patients who had been previously treated

with high-dose therapies. Toxicity was very mild. The

study demonstrates worthwhile activity and justifies

the inclusion of vinorelbine in combination therapies

for lymphoma.