Cures for Cancer, AIDS & Leukemia?

[Guest guest]

This letter was first posted to The Internet on October 31, 2000.

Hello everyone,

My research has raised several questions (bold face emphasis is mine.).

Could Cancer and AIDS be cured by these 'chemical cousins' ? -

Cancer: Thiazolidine-4-carboxylic acid known as 'Thioproline' and 'Tac',

AIDS: L-2-Methylthiazolidine-4-carboxylic acid known as 'L-MTCA'.

Tac is composed of formaldehyde (one half) & L-cysteine (one half).

L-MTCA is composed of acetaldehyde (one half) & L-cysteine (one half).

Both Tac and L-MTCA are chemically simple to prepare; however, the procedures could be dangerous -

Tac - Ratner first described its preparation in the journal of the 'American Chemical Society', January, 1937, page 203:

" Thiazolidine-4-carboxylic Acid. - The cysteine hydrochloride from 30 g. of cystine was dissolved in 100 cc. of water; 22 cc. of commercial 40% formaldehyde (1.1 mole) was added, and the mixture allowed to stand overnight at room temperature. On the addition of 25 cc. of pyridine, crystals soon separated. The whole was diluted with 50 cc. of alcohol and filtered. The product (28.2 g.) was recrystallized from hot water. The resulting long, colorless needles, which melt with decomposition at 196-197 degrees, are insoluble in alcohol, somewhat soluble in cold water, readily soluble in hot water, in acid and in alkali. "

* HAZARD ALERT: Formaldehyde is an alleged carcinogen and a strong irritant; avoid breathing vapor and avoid skin contact. Use a fume hood.

L-MTCA - This description is found in the 'Journal of Nutrition', Volume 66, 1958, page 610:

" L-2-Methylthiazolidine-4-carboxylic acid was synthesized by a modification of the procedure described by Cook and Heilbron (THE CHEMISTRY OF PENICILLIN). Six grams of L-cysteine were dissolved in 15 ml of hot water and the pH of the solution was adjusted to 2.5 with hydrochloric acid. Five milliliters of freshly distilled acetaldehyde were added and the reaction mixture was allowed to stand at room temperature for several hours. The solution was then concentrated 'in vacuo' to a heavy syrup. The product was precipitated by the addition of absolute ethanol and collected on a sintered glass funnel. The yield, after recrystallization from 95% ethanol, was 2.6 gm. The melting point was 162-163 degrees, in agreement with the value reported by Cook and Heilbron. "

* HAZARD ALERT: Hydrochloric acid is highly toxic by ingestion or inhalation; severely corrosive to skin and eyes.

* HAZARD ALERT: Acetaldehyde is a suspected carcinogen; highly flammable; toxic (narcotic); dangerous fire and explosion risk. Cool before opening. Open bottle slowly under a hood.

A. More information about Tac - The cure for Cancer?

1. In March, 1979, Gosalvez stated that Tac was unique - " One compound out of 500... " - and speculated that Tac " ...could represent the first non-cytotoxic anticancer agent which has the plasma membrane as target. "

2. Later in 1979, Dr. Gosalvez and Dr. Brugarolas achieved these anti-Cancer results with Tac in a Spanish clinical trial:

" ...Definite signs of activity were observed...in other tumours, such as breast, renal, ovary, thyroid, and parotid cancer. "

" ...Histological studies showed involution and transformation into low-grade malignancies and disappearance of evidence of cancer. "

3. In 1980, the biochemist, T.F. Slater, wrote a letter to 'The Lancet' in which he stated:

" Thus there is a lot of published information relevant to the current interesting work on thioproline. In particular, the stimulation in vivo of lipid peroxidation, with the subsequent formation of unsaturated aldehydic products, offers exciting possibilities for the in situ formation of thiazolidine adducts, especially since lipid peroxidation is reduced in many experimental tumours so that endogenous production of such unsaturated aldehydes is very much decreased by that route. "

4. In 1983 the research of Smeyers and Huertas labelled Tac as containing 'anti-cancer molecules'.

5. In the past decade the Nobel Prize winner, Professor V. Schally, and his colleagues incorporated Tac into compounds ('BN antagonists') and made these statements:

1994 - " ...BN antagonists such as RC-3950-II (j.s.r. - contains Tac) may have important therapeutic applications for the treatment of various malignancies such as prostatic, gastric, and pancreatic cancer, small cell lung carcinoma, and other tumors. "

1997 - " ...These highly potent cytotoxic analogs of BN have been designed as targeted anti-tumor agents for the treatment of various cancers that possess receptors for BN/GRP. "

6. Like all chemotherapeutic agents, Tac is somewhat toxic (however - Tylenol is more toxic!).

7. Vitamin C neutralizes the toxicity of Tac. This fact would enable Cancer patients to swallow 'mega-doses' of Tac. No painful intravenous or intramuscular injections would be required!

8. 98% pure Tac is available at -

Alfa Aesar Consult Alfa Aesar Online Catalog

A Matthey Catalog Company, Inc. L-Thiazolidine-4-carboxylic acid

30 Bond Street (Thioproline, Tac)

Ward Hill, Massachusetts 01835-8099 Item: A15033

phone (800) 343-7276 & (978) 521-6300 CAS Number: 34592-47-7

FAX (978) 521-6350 Price: 250g $132.00.

B. More information about L-MTCA - The cure for AIDS?

1. To repeat: L-MTCA is composed of acetaldehyde (one half) and L-cysteine (one half).

2. HIV, the virus that causes AIDS, can be inactivated in the test tube by acetaldehyde. This fact has been confirmed by both the National Institutes of Health (NIH) and Centers for Disease Control (CDC).

3. Japanese researchers have shown that a compound containing a form of acetaldehyde (diethylacetal) had severe consequences upon the 'gag proteins' of HIV; for instance, access 'MedLine', www.ncbi.nlm.nih.gov/pubmed -

a. Type in 90121218, click on to 'Tashiro A', the abstract concludes: " .....In this system, N-Myr-Goa substantially inhibited more than 90% of the N-Myristoylation of p17 gag protein produced in the HIV-1-infected MT-4 cells. These results suggest that the N-myristoylation of p17 gag protein of HIV-1 may be essential in its structural assembly or maturation. "

b. Type in 89033966, click on to 'Shoji S', the last sentence of the abstract states: " .....Of the N-Myr-compounds tested, N-Myr-GOA remarkably prevented the myristoylation of p19gag and p17gag..... "

N-Myr-Goa is 'N-myristoyl glycinal diethylacetal'. 'Diethylacetal', a form of acetaldehyde, has a Molecular weight of 118.18 and is less soluble than acetaldehyde (Molecular weight - 44.05); 'pure' acetaldehyde would be the most effective agent to cause the 'anti-myristoylation' of HIV's gag proteins, namely - p17, p41 & Pr55.

4. The toxicity of acetaldehyde can be neutralized by L-Cysteic acid.H20 and vitamin C (ascorbic acid); refer to " Protective Action of Ascorbic Acid and Sulfur Compounds against Acetaldehyde Toxicity: Implications in Alcoholism and Smoking " by Dr. Herbert Sprince et al, 'Agents and Actions', vol. 5/2 (1975).

5. Could the cure for AIDS be the combination of L-MTCA & L-Cysteic acid.H20 & vitamin C?

6. I cannot locate any source in the world that presently stocks or sells L-MTCA; however, Sigma-Aldrich of Milwaukee, Wisconsin, (800) 771-6737, stocks a product that is closely related to it -

Sigma-Aldrich, product S71006 is 2,2-DIMETHYL-THIAZOLIDINE-4-CARBOXYLIC ACID whereas

L-MTCA is L-2-METHYLTHIAZOLIDINE-4-CARBOXYLIC ACID.

I am sure that Sigma-Aldrich would have no problem in manufacturing L-MTCA if it proves to be the cure for AIDS.

C. Chronic Myelogenous Leukemia (CML) - If you type penicillamine leukemia into 'MedLine',

www.ncbi.nlm.nih.gov/pubmed, you will find that there are 24 entries that are devoted to this subject. I have found the following one to be the most interesting; the unique identifier number is 96273151; I have taken one sentence from it:

" .....Human acute myelogenous leukemia cells were especially sensitive to PSH plus copper..... " .

PSH is d-penicillamine.

A relationship exists between Penicillamine and Thiazolidine-4-carboxylic acid (Thioproline, Tac).

The 1999 edition of the PHYSICIANS' DESK REFERENCE (PDR) states on page 1766 that penicillamine

" reacts readily with formaldehyde or acetone to form a thiazolidine-carboxylic acid. "

I will state unequivocally that the 'thiazolidine-carboxylic acid' that the PDR mentions is the same as Thioproline (Tac). I challenge the scientific and medical community of the world to refute me.

Since vitamin C (ascorbic acid) protects against the toxicity of Thioproline, might it also protect against the toxicity of penicillamine?

On about October 12, 1999, I called Dr. Cathcart's office; I believe Dr. Cathcart is a former associate of

Dr. Linus ing; Dr. Cathcart's website is www.orthomed.com and it reads:

'ORTHOMOLECULAR MEDICINE

VITAMIN C

ROBERT F. CATHCART, M.D.'

and left this question - " Does vitamin C afford protection against the toxicity of penicillamine? "

The next day Dr. Cathcart's secretary called me and said that " Dr. Cathcart doesn't have any personal experience with what you mentioned, but in theory he could see how vitamin C could protect against penicillamine. "

a. A scientific fact - Human acute myelogenous leukemia cells are especially sensitive to

d-penicillamine plus copper.

b. A scientific opinion - vitamin C could possibly protect against penicillamine.

c. A scientific hypothesis - 'Mega-doses' of d-penicillamine plus copper and vitamin C

will cure chronic myelogenous leukemia.

I wish to conclude by asking this question -

Have I discovered the cures for Cancer, AIDS and Leukemia?

Yours truly, , jsr1936@..., P.O. Box H, Hobart, IN 46342, (219) 763-1933

Post Script -

1. Habitual drinkers of alcohol need to consume above average amounts of

zinc, vitamin B-6 and vitamin C.

2. Superoxide dismutase (SOD) might help those who suffer from Lou Gehrig's Disease.

3. Ginkgo Biloba and zinc might help those who suffer from Macular Degeneration.

4. More details of my research can be found in

a. The Cure for Cancer? www.cures for cancer.ws/cures for cancer/tac-cure.htm

b. Letter - 'To Dr. Varmus, Director, National Institutes of Health (NIH)', November 7, 1999

c. Letter - 'Anti-Cancer research missing from Federal Archive', September 10, 2000.

Upon request I will eMail the letters to anyone.

5. My latest bulletin (8 " x14 " ) reads:

Doctors and my fellow citizens

you are invited to appear on my T.V. program

'Alternative Health Choices'.

I talk about these ailments -

1. Cancer patients need Tac !

A. Tac contains " anti-cancer molecules " .

B. Tac caused " disappearance of evidence of cancer. "

C. Tac affected all kinds of cancer in 1979.

D. A Nobel Prize winner said in 1994 and 1997 that a

chemical containing Tac might be effective in treating

various kinds of cancer.

2. AIDS

3. Alcohol Abuse

4. Lou Gehrig's Disease (ALS)

5. Macular Degeneration (vision loss)

6. Leukemia

S. , (219) 763-1933

'Tac' is Thiazolidine-4-carboxylic acid. For more

information, refer to one of the world's foremost

medical journals 'The Lancet', 1/12/1980, pp. 68-70.

'Alternative Health Choices' is shown on

AT & T cable television.

Portage, Indiana, Wednesdays, 5:30 P.M., Channel 4

Copies by regular mail to -

Congressman J. Visclosky, Washington, D.C.

Professor V. Schally, Department of Veterans Affairs, New Orleans, Louisiana

Donna E. Shalala, Ph.D., Secretary of Health and Human Services, Washington, D.C.

Harold E. Varmus, M.D., Director, National Institutes of Health (NIH), Bethesda, land

Klausner, M.D., Director, National Cancer Institute (NCI), Bethesda, land

Lake/Porter County Medical Society, Merrillville, Indiana

Chiedu J. Nchekwube, M.D., Family Medicine and Wellness Center, Merrillville, Indiana

eMail copies will be sent to individuals and groups concerned with the health problems

that I have discussed in this letter. j.s.r.