Selenium + Cancer

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Hi,

Selenium is a harmless susbstance that is a vital part of an wholistic approach to cancer treatment. Selenium is necessary for the body to make Glutathione.

L-Selenomethionine is the only form of selenium to take. If you take cheap "selenite", then the vitamin C you take for cancer control (in synergy with beta glucan) will reduce the selenite to elemental metallic selenium which is not bio- available at all.

Some people take 500 to 1000 mcg per day which is more than the recommended daily allowance of 200mcg. In China some people living in areas with high selenium soils eat 1500mcg per day in their natural diet, without any side effects.

Investigators have mapped the selenium content of the various states of the United States and have found its distribution highly uneven, with the highest levels in South Dakota and the lowest in Ohio. These researchers have shown that Rapid City, South Dakota, has the lowest overall cancer mortality rate in the nation, while Ohio has a rate nearly double that of South Dakota.

Similar Low Selenium - High Cancer correlations have been found in China, Finland and Brazil.

SELENIUM REFERENCES

University of Arizona researcher Larry , M.D., conducted a

seven-year study involving more than 1,000 older people with skin

cancer. Half of the patients took selenium supplements during the

study, the remaining half took placebos.

Selenium supplementation was associated with a reduction in

cancer incidence of 42%, and also appeared to reduce the risk of

dying from cancer in treated patients, reported Dr. .

Others have confirmed these studies and extended them to more

than twenty other nations: the lower the selenium intake, they

found, the higher the incidence of leukemia and cancers of the

colon, rectum, pancreas, breast, ovary, prostate, bladder, skin

and (in the male) lungs.

Experimental evidence has shown that selenium added to food or

water in doses of 0.5 to 6 ppm (parts per million) has

significantly reduced the incidence of liver, skin, mammary and

colon cancers in various laboratory animals.

2. Immuno-stimulant: Large increases in antibody production following

administration of selenium have been demonstrated in animal studies.

Up to thirty fold increases have been related to the administration

of combination selenium/ Vitamin E .

In one of these experiments, female mice specially bred to

develop spontaneous breast tumors were divided into two groups.

The controls received normal diet; the experimentals were given

selenium supplements. Breast cancers occurred, as expected, in 82

percent of the controls but in only 10 percent of the selenium

supplemented experimentals. The evidence is very strong that

selenium, in doses that exceed the normal nutritional range, inhibits

cancer formation in some, perhaps most, animals.

Prospective, case-control and nested case-control studies. Analysis of

blood serum levels indicated that patients with cancer, particularly

gastrointestinal cancer, prostatic cancer, or Hodgkin's lymphoma, had

significantly lower blood selenium levels than healthy patients

(Shamberger et al., 1973; Salonen et al., 1984; Kok et al., 1987; Willet

et al., 1983; Willet and Stampfer, 1986). The risk of cancer for men (Kok

et al., 1987) or for all subjects (Willet et al., 1983) in the lowest

quintile of serum selenium was twice that of subjects with higher levels.

Schrauzer, G.N., D.A. White and C.J. Schneider. 1976. Inhibition of the

genesis of spontaneous mammary tumors in C3H mice: Effects of selenium and

of selenium-antagonistic elements and their possible role in human breast

cancer. Bioinorg. Chem. 6(3): 265-270.

Schrauzer, G.N. and D. Ishmael. 1974. Effects of selenium and of arsenic

on the genesis of spontaneous mammary tumors in inbred C3H mice. Ann.

Clin. Lab. Sci. 4(6): 441-447.

Title

Mammary cancer prevention by regular garlic and selenium-enriched garlic.

Author

Ip C; Lisk DJ; Stoewsand GS

Source: Nutr Cancer, 1992, 17:3, 279-86

Abstract

The anticarcinogenic activities of regular (soil-grown) garlic and

selenium-enriched garlic (cultivated in the greenhouse) were

evaluated using the 7,12-dimethylbenz[a]anthracene-(DMBA) induced

mammary tumor

model in rats. In Experiment 1, milled regular garlic powder was

added to the basal AIN-76A diet at 20 g/kg. In

Experiment 3, the anticarcinogenic activity of selenium-enriched

garlic (containing 150 ppm Se dry weight from growth in a

selenium-fertilized medium) was compared with that of regular

garlic as well as selenite. Animals given the selenium-enriched

garlic (final concentration 3 ppm Se in the diet) developed the

fewest mammary tumors. Our study demonstrated the feasibility of

achieving cancer prevention with the use of a selenium-rich food

system.

1: Br J Urol 1998 May;81(5):730-4

Decreased incidence of prostate cancer with selenium supplementation: results of

a double-blind cancer prevention trial.

LC, Dalkin B, Krongrad A, Combs GF, Turnbull BW, Slate EH, Witherington R,

Herlong JH, Janosko E, Carpenter D, Borosso C, Falk S, Rounder J

Arizona Cancer Center, College of Medicine, University of Arizona, Tucson 85716,

USA.

OBJECTIVE: To test if supplemental dietary selenium is associated with changes

in the incidence of prostate cancer. PATIENTS AND METHOD: A total of 974 men

with a history of either a basal cell or squamous cell carcinoma were randomized

to either a daily supplement of 200 microg of selenium or a placebo. Patients

were treated for a mean of 4.5 years and followed for a mean of 6.5 years.

RESULTS: Selenium treatment was associated with a significant (63%) reduction in

the secondary endpoint of prostate cancer incidence during 1983-93. There were

13 prostate cancer cases in the selenium-treated group and 35 cases in the

placebo group (relative risk, RR=0.37, P=0.002).

There were significant health benefits also for the other secondary

endpoints of total cancer mortality, and the incidence of total, lung and

colorectal cancer. CONCLUSIONS: The selenium-treated group had

substantial reductions in the incidence of prostate cancer, and total cancer

incidence and mortality that demand further evaluation in well-controlled

prevention trials.

PMID: 9634050

1: Am J Epidemiol 1998 Nov 15;148(10):975-82

Is low selenium status a risk factor for lung cancer?

Knekt P, Marniemi J, Teppo L, Heliovaara M, Aromaa A

National Public Health Institute, Helsinki, Finland.

The hypothesis that low selenium may in some circumstances be a risk factor for

lung cancer was investigated in a case-control study nested within a

longitudinal study. Serum samples from 9,101 cancer-free individuals were

collected and stored at -20 degrees C by the Finnish Mobile Clinic in 1968-1971

and 1973-1976. During follow-up until the end of 1991, 95 cases of lung cancer

were diagnosed. Selenium concentrations were determined from the serum samples

of the cases and 190 controls, individually matched for sex, age, and place of

residence. In accordance with the hypothesis, the findings suggest that very low selenium status may contribute to the risk of lung cancer.

PMID: 9829869

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